The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
23Na MRI accurately measures fixed charge density in articular cartilage
Open accessAbstract
One of the initiating steps of osteoarthritis is the loss of proteoglycan (PG) molecules from the cartilage matrix. One method for assessing cartilage integrity, therefore, is to measure the PG content or fixed charge density (FCD) of cartilage. This report shows the feasibility of calculating FCD by 23 Na MRI and introduces MRI protocols for human studies, in vivo. 23 Na MRI was used to measure the sodium concentration inside bovine patellar cartilage. The sodium concentration was then converted to FCD (mM) by considering ideal Donnan equilibrium. These FCD measurements were compared to FCD measurements obtained through standard dimethylmethylene blue PG assays. There was a high correlation (slope = 0.89, r 2 = 0.81) between the FCD measurements obtained by 23 Na MRI and those obtained by the PG assays. These methods were then employed in quantifying the FCD of articular cartilage of human volunteers in vivo. Two imaging protocols were compared: one using a birdcage coil, the other using a transmit/receive surface coil. Both methodologies gave similar results, with the average sodium concentration of normal human patellar cartilage ranging from ∼240 to 260 mM. This corresponds to FCDs of –158 mM to –182 mM. Magn Reson Med 47:284–291, 2002. © 2002 Wiley‐Liss, Inc.
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Data Reduction and Error Analysis for the Physical Sciences
Bevington, P. R., Robinson, D. K., Blair, J. M., Mallinckrodt, A. J., & McKay, S. (1993) · Computers in Physics · doi:10.1063/1.4823194 · Cited by 14,824
MANKIN, H. J., DORFMAN, H., LIPPIELLO, L., & ZARINS, A. (1971) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-197153030-00009 · Cited by 1,963
Charalambous, C. P. (2014) · Classic Papers in Orthopaedics · doi:10.1007/978-1-4471-5451-8_97 · Cited by 1,835
A Direct Spectrophotometric Microassay for Sulfated Glycosaminoglycans in Cartilage Cultures
Farndale, R. W., Sayers, C. A., & Barrett, A. J. (1982) · Connective Tissue Research · doi:10.3109/03008208209160269 · Cited by 1,347
Mankin, H. J., Dorfman, H., Lippiello, L., & Zarins, A. (1971) · PubMed · Cited by 796
Venn, M., & Maroudas, A. (1977) · Annals of the Rheumatic Diseases · doi:10.1136/ard.36.2.121 · Cited by 572
Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI
Bashir, A., Gray, M. L., Hartke, J., & Burstein, D. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199905)41:5<857::aid-mrm1>3.0.co;2-e · Cited by 571
Data Reduction and Error Analysis for the Physical Sciences, 2nd ed.
Bevington, P. R., Robinson, D. K., & Bunce, G. (1993) · American Journal of Physics · doi:10.1119/1.17439 · Cited by 559
Burstein, D., Velyvis, J., Scott, K. T., Stock, K. W., Kim, Y.-J., Jaramillo, D., Boutin, R. D., & Gray, M. L. (2001) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200101)45:1<36::aid-mrm1006>3.0.co;2-w · Cited by 533
Gd‐DTPA2− as a measure of cartilage degradation
Bashir, A., Gray, M. L., & Burstein, D. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360504 · Cited by 507
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The Basic Science of Articular Cartilage: Structure, Composition, and Function
Sophia Fox, A. J., Bedi, A., & Rodeo, S. A. (2009) · Sports Health: A Multidisciplinary Approach · doi:10.1177/1941738109350438 · Cited by 2,774
Pros and cons of ultra-high-field MRI/MRS for human application
Ladd, M. E., Bachert, P., Meyerspeer, M., Moser, E., Nagel, A. M., Norris, D. G., Schmitter, S., Speck, O., Straub, S., & Zaiss, M. (2018) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2018.06.001 · Cited by 544
In vivo T1ρ and T2 mapping of articular cartilage in osteoarthritis of the knee using 3 T MRI
Li, X., Benjamin Ma, C., Link, T. M., Castillo, D.-D., Blumenkrantz, G., Lozano, J., Carballido-Gamio, J., Ries, M., & Majumdar, S. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.01.011 · Cited by 485
Advances in Imaging of Osteoarthritis and Cartilage
Roemer, F. W., Crema, M. D., Trattnig, S., & Guermazi, A. (2011) · Radiology · doi:10.1148/radiol.11101359 · Cited by 220
Metadata
- Authors
- Shapiro, E. M., Borthakur, A., Gougoutas, A., & Reddy, R.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2002-01-23
- Volume
- 47
- Issue
- 2
- Pages
- 284-291
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2026076082
- Cited by
- 261
- References
- 18
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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