Assessment of dynamic susceptibility contrast cerebral blood flow response to amphetamine challenge: A human pharmacological magnetic resonance imaging study at 1.5 and 4 T
Open accessAbstract
Pharmacological MRI (phMRI) techniques can be used to monitor the neurophysiological effects of central nervous system (CNS) active drugs. In this study, we investigated whether dynamic susceptibility contrast (DSC) perfusion imaging employing the use of superparamagnetic iron oxide nanoparticles (Resovist) could be used to measure hemodynamic response to d-amphetamine challenge in human subjects at both 1.5 and 4 T. Significant changes in cerebral blood flow (CBF) were found in focal regions associated with the nigrostriatal circuit and mesolimbic and mesocortical dopaminergic pathways. More significant CBF responses were found at higher field strength, mainly within striatal structures. The results from this study indicate that DSC perfusion imaging using Resovist can be used to assess the efficacy of CNS-active drugs and may play a role in the development of novel psychiatric therapies at the preclinical level.
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Amphetamine alters regional cerebral blood flow to areas with dopamine innervation, including striatum, anterior cingulate cortex, prefrontal and parietal cortex, inferior orbital cortex, thalamus, cerebellum, and amygdala.
“AMP also has been shown to alter regional CBF to areas of the brain with DA innervation, including the striatum, anterior cingulate cortex, prefrontal and parietal cortex, inferior orbital cortex, thalamus, cerebellum, and amygdala (135, 155, 156, 160, 163).”
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Mattay, V. S., Berman, K. F., Ostrem, J. L., Esposito, G., Van Horn, J. D., Bigelow, L. B., & Weinberger, D. R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04816.1996 · Cited by 151 · see citing works
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Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Weinstein, J. S., Varallyay, C. G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W. D., Muldoon, L. L., & Neuwelt, E. A. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.192 · Cited by 500 · see citing works
- Authors
- Rose, S. E., Janke, A. L., Strudwick, M. W., McMahon, K. L., Chalk, J. B., Snyder, P., & De zubicaray, G. I.
- Affiliations
- The University of Queensland (AU)
- Pfizer (United States) (US)
- Corresponding author
- Rose, Stephen E.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2005-12-08
- Volume
- 55
- Issue
- 1
- Pages
- 9-15
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2086897041
- Cited by
- 20
- References
- 1
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2018: 1 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- dynamic susceptibility contrast MRI, cerebral blood flow, amphetamine challenge, Resovist, superparamagnetic iron oxide nanoparticles, dopaminergic pathways, striatum, field strength dependence, CNS-active drugs, drug efficacy evaluation, psychiatric drug development
- MeSH terms
- Adult, Amphetamine, Cerebrovascular Circulation, Contrast Media, Dextrans, Humans, Image Processing, Computer-Assisted, Iron, Magnetic Resonance Imaging, Male, Oxides, Ferrosoferric Oxide, Magnetite Nanoparticles
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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