Investigation of resolution effects using a specialized diffusion tensor phantom
Abstract
Purpose: The clinical potential of the diffusion imaging‐based analysis of fine brain structures such as fornix or cingulum is high due to the central role of these structures in psychiatric diseases. However, the quantification of diffusion parameters in fine structures is especially prone to partial volume effects (PVEs). Methods: In this study, a phantom for the investigation of PVEs and their influence on diffusion parameters in fine structures of different diameter is presented. The phantom is produced by winding wet polyester fibers onto a spindle. The resulting fiber strands have well defined square cross‐sections of 1–25 mm 2 and provide a homogeneous and high fractional anisotropy (FA ≈ 0.9). Results: Several PVEs are demonstrated and analyzed. It is shown that inferred results such as the fiber geometry and diffusion parameters strongly depend on the relative position of the structure of interest to the voxel‐grid. Several implications of PVEs on post‐processing methods such as Tract‐based Spatial Statistics and fiber tractography are demonstrated. Conclusion: These results show that the handling of PVEs in common post‐processing tasks can be problematic, and that the presented phantom provides a valuable tool for the improvement and evaluation of these effects. Magn Reson Med 71:1108–1116, 2014. © 2013 Wiley Periodicals, Inc.
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Ex vivo imaging and tracing or physically and numerically simulated phantoms allow validation to some extent, and in specific circumstances such as basic fiber configurations.
“Ex vivo imaging and tracing17–23 or physically24–30 and numerically simulated phantoms31–34 allow validation to some extent, and in specific circumstances such as basic fiber configurations.”
From Tractography-based connectomes are dominated by false-positive connections (2016) · cites this paper as [24]
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- Authors
- Bach, M., Fritzsche, K. H., Stieltjes, B., & Laun, F. B.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Laun, Frederik B.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2013-05-08
- Volume
- 71
- Issue
- 3
- Pages
- 1108-1116
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W1513152404
- Cited by
- 32
- References
- 31
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (LA 2804/1-1)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- partial volume effect, diffusion tensor imaging, diffusion phantom, fractional anisotropy, fornix, cingulum, tract-based spatial statistics, fiber tractography, resolution effects
- MeSH terms
- Algorithms, Brain, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Nerve Fibers, Myelinated, Sensitivity and Specificity, Reproducibility of Results, Phantoms, Imaging, Diffusion Tensor Imaging
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