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Cited by 26

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effects of exercise and creatine on myosin heavy chain isoform composition in patients with Charcot-Marie-Tooth disease

Smith, Cheryl A., Chetlin, Robert D., Gutmann, Laurie, Yeater, Rachel A., Alway, Stephen E.·2006·Muscle & Nerve
DOI 10.1002/mus.20621
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Abstract

It is not known whether myosin heavy chain (MHC) content changes in response to exercise training or creatine supplementation in subjects with Charcot–Marie–Tooth disease (CMT). Based on previous data, we hypothesized that resistance exercise and creatine would increase the percentage of type I MHC composition in the vastus lateralis muscle and that myosin isoform changes would correlate with improved chair rise‐time in CMT subjects. To test this hypothesis, 18 CMT subjects were randomly assigned to either a placebo or creatine group. All subjects performed a 12‐week, home‐based, moderate‐intensity resistance training program. Chair rise‐time was measured before and after the training program. Muscle biopsies were obtained from the vastus lateralis before and after the 12‐week program. Gel electrophoresis showed a significant decrease (∼30%) in MHC type I in CMT subjects given creatine supplementation when compared with placebo. There was a nonsignificant increase in both MHC type IIa (∼23%) and MHC type IIx (∼7%) in CMT subjects given creatine. Reduced MHC type I content and increased MHC type IIa content correlated with faster chair rise‐times (i.e., improved muscle performance). The training‐induced change in MHC IIa content was inversely correlated with chair rise‐time in CMT subjects given creatine. When the two subject groups were combined, there was a linear, negative relationship between the change in MHC type IIa content and chair rise‐time after training and a positive relationship between the training‐induced change in MHC type I content and chair rise‐time. These data suggest that improved function (chair rise‐time) was associated with a lower level of MHC type I and increased MHC type IIa composition. Furthermore, the data are consistent with the hypothesis that creatine supplementation alters MHC composition in CMT patients undergoing resistance training and that MHC changes associated with creatine supplementation can improve muscle function. Muscle Nerve, 2006

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Metadata

Authors
Smith, C. A., Chetlin, R. D., Gutmann, L., Yeater, R. A., & Alway, S. E.
Venue
Muscle & Nerve
Publisher
Wiley
Published
2006-07-31
Volume
34
Issue
5
Pages
586-594
ISSN
  • 0148-639X
  • 1097-4598
DOI
10.1002/mus.20621
Cited by
26
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Effects of exercise and creatine on myosin heavy chain isoform composition in patients with Charcot-Marie-Tooth disease. https://app.cochat.ai/papers/10.1002/mus.20621
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Smith, C. A., Chetlin, R. D., Gutmann, L., Yeater, R. A., & Alway, S. E. (2006). Effects of exercise and creatine on myosin heavy chain isoform composition in patients with Charcot-Marie-Tooth disease. Muscle & Nerve. https://doi.org/10.1002/mus.20621

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