Cited by 32Ion channel regulation and functionPotassium and Related DisordersCardiac electrophysiology and arrhythmias

INa and IKir are reduced in Type 1 hypokalemic and thyrotoxic periodic paralysis

Puwanant, Araya, Ruff, Robert L.·2010·Muscle & Nerve

Abstract

We evaluated voltage‐gated Na+ (I Na) and inward rectifier K+ (I Kir) currents and Na+ conductance (G Na) in patients with Type 1 hypokalemic (HOPP) and thyrotoxic periodic paralysis (TPP). We studied intercostal muscle fibers from five subjects with HOPP and one with TPP. TPP was studied when the patient was thyrotoxic (T‐toxic) and euthyroid. We measured: (1) I Kir, (2) action potential thresholds, (3) I Na, (4) G Na, (5) intracellular [Ca 2+], and (6) histochemical fiber type. HOPP fibers had lower I Na, G Na, and I Kir and increased action potential thresholds. Paralytic attack frequency correlated with the action potential threshold, G Na and I Na, but not with I Kir. G Na, I Na, and [Ca 2+] varied with fiber type. HOPP fibers had increased [Ca 2+]. The subject with TPP had values for G Na, I Na, action potential threshold, I Kir, and [Ca 2+] that were similar to HOPP when T‐toxic and to controls when euthyroid. HOPP T‐toxic TPP fibers had altered G Na, I Na, and I Kir associated with elevation in [Ca 2+]. Muscle Nerve, 2010

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Crossref · 10.1002/mus.21693

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  • The outward Kir current is decreased in intercostal muscle fibers of both patients with TPP and familial hypokalemic periodic paralysis.

    “Studies have shown that the outward Kir current is decreased in intercostal muscle fibers of both patients with TPP and familial hypokalemic periodic paralysis [16].”

    From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [16]

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Authors
Puwanant, A., & Ruff, R. L.
Affiliations
University Hospitals of Cleveland (US)
Corresponding author
Ruff, Robert L.
Venue
Muscle & Nerve
Publisher
Wiley
Published
2010-08-24
Volume
42
Issue
3
Pages
315-327
ISSN
  • 0148-639X (ISSN-L)
  • 1097-4598
OpenAlex
W2071625473
Cited by
32
References
58
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 3
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Locations
  • Muscle & Nerve (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
thyrotoxic periodic paralysis, voltage-gated sodium current, inward rectifier potassium current, sodium conductance, action potential threshold, intracellular calcium, fiber type, thyrotoxicosis
MeSH terms
Action Potentials, Cell Membrane, DNA, Electrophysiology, Family, Histocytochemistry, Humans, Insulin, Male, Membrane Potentials, Microelectrodes, Potassium, Thyrotoxicosis, Sodium Channels, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Weakness, Hypokalemic Periodic Paralysis, Potassium Channels, Inwardly Rectifying

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