INa and IKir are reduced in Type 1 hypokalemic and thyrotoxic periodic paralysis
Abstract
We evaluated voltage‐gated Na+ (I Na) and inward rectifier K+ (I Kir) currents and Na+ conductance (G Na) in patients with Type 1 hypokalemic (HOPP) and thyrotoxic periodic paralysis (TPP). We studied intercostal muscle fibers from five subjects with HOPP and one with TPP. TPP was studied when the patient was thyrotoxic (T‐toxic) and euthyroid. We measured: (1) I Kir, (2) action potential thresholds, (3) I Na, (4) G Na, (5) intracellular [Ca 2+], and (6) histochemical fiber type. HOPP fibers had lower I Na, G Na, and I Kir and increased action potential thresholds. Paralytic attack frequency correlated with the action potential threshold, G Na and I Na, but not with I Kir. G Na, I Na, and [Ca 2+] varied with fiber type. HOPP fibers had increased [Ca 2+]. The subject with TPP had values for G Na, I Na, action potential threshold, I Kir, and [Ca 2+] that were similar to HOPP when T‐toxic and to controls when euthyroid. HOPP T‐toxic TPP fibers had altered G Na, I Na, and I Kir associated with elevation in [Ca 2+]. Muscle Nerve, 2010
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The outward Kir current is decreased in intercostal muscle fibers of both patients with TPP and familial hypokalemic periodic paralysis.
“Studies have shown that the outward Kir current is decreased in intercostal muscle fibers of both patients with TPP and familial hypokalemic periodic paralysis [16].”
From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [16]
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- Authors
- Puwanant, A., & Ruff, R. L.
- Affiliations
- University Hospitals of Cleveland (US)
- Corresponding author
- Ruff, Robert L.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2010-08-24
- Volume
- 42
- Issue
- 3
- Pages
- 315-327
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2071625473
- Cited by
- 32
- References
- 58
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- thyrotoxic periodic paralysis, voltage-gated sodium current, inward rectifier potassium current, sodium conductance, action potential threshold, intracellular calcium, fiber type, thyrotoxicosis
- MeSH terms
- Action Potentials, Cell Membrane, DNA, Electrophysiology, Family, Histocytochemistry, Humans, Insulin, Male, Membrane Potentials, Microelectrodes, Potassium, Thyrotoxicosis, Sodium Channels, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Weakness, Hypokalemic Periodic Paralysis, Potassium Channels, Inwardly Rectifying
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