The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Large delayed plasma creatine kinase changes after stepping exercise
Abstract
Muscle changes have been examined in 16 normal subjects (eight female) after both a 20‐minute and a prolonged step test. Stepping differs from most exercise tests in that it involves eccentric contractions (negative work) in which the active muscle is lengthened. Plasma creatine kinase (CK), muscle force, contractile properties, and tenderness in the quadriceps were measured for up to 9 days after the exercise. Muscle tenderness was experienced only in the muscles that had performed eccentric contractions (i.e., stepped down). All subjects showed some early rise in CK (<400 IU/liter) but eight (both male and female) showed a much greater response (up to 34,500 IU/liter) which took a long time to reach peak levels (4–5 days after stepping). It is suggested that eccentric contractions involved in this form of exercise result in some particular form of muscle damage which, in susceptible subjects, may initiate changes giving rise to a large delayed release of muscle enzymes.
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Cites
The relation between force and speed in muscular contraction
Katz, B. (1939) · The Journal of Physiology · doi:10.1113/jphysiol.1939.sp003756 · Cited by 808
The physiological cost of negative work
Abbott, B. C., Bigland, B., & Ritchie, J. M. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004755 · Cited by 642
Human Skeletal Muscle Function: Description of Tests and Normal Values
Edwards, R. H. T., Young, A., Hosking, G. P., & Jones, D. A. (1977) · Clinical Science · doi:10.1042/cs0520283 · Cited by 500
Self-citationPain and Fatigue after Concentric and Eccentric Muscle Contractions
Newham, D. J., Mills, K. R., Quigley, B. M., & Edwards, R. H. T. (1983) · Clinical Science · doi:10.1042/cs0640055 · Cited by 471
Self-citationA morphological study of delayed muscle soreness
Fridén, J., Sjöström, M., & Ekblom, B. (1981) · Experientia · doi:10.1007/bf01986165 · Cited by 370
KOMI, P. V., & BUSKIRK, E. R. (1972) · Ergonomics · doi:10.1080/00140137208924444 · Cited by 366
Positive and negative work performances and their efficiencies in human locomotion
Margaria, R. (1968) · Internationale Zeitschrift f�r Angewandte Physiologie Einschlie�lich Arbeitsphysiologie · doi:10.1007/bf00699624 · Cited by 272
Positive and Negative Muscular Work.
ASMUSSEN., E. (1953) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1953.tb00988.x · Cited by 247
Increased serum creatine kinase after exercise
Shumate, J. B., Brooke, M. H., Carroll, J. E., & Davis, J. E. (1979) · Neurology · doi:10.1212/wnl.29.6.902 · Cited by 127
Chemical and Mechanical Changes during Stretching of Activated Frog Skeletal MusclePreprint
Curtin, N. A., & Davies, R. E. (1973) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1973.037.01.074 · Cited by 115
Cited by
Delayed Onset Muscle Soreness: Treatment Strategies and Performance Factors
Cheung, K., Hume, P. A., & Maxwell, L. (2003) · Sports Medicine · doi:10.2165/00007256-200333020-00005 · Cited by 1,350
Lumeij, J. T. (1997) · Clinical Biochemistry of Domestic Animals · doi:10.1016/b978-012396305-5/50031-2 · Cited by 1,163
Ultrastructural changes after concentric and eccentric contractions of human muscle
Newham, D. J., McPhail, G., Mills, K. R., & Edwards, R. H. T. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90058-8 · Cited by 602
Self-citationEffect of ibuprofen and acetaminophen on postexercise muscle protein synthesis
Trappe, T. A., White, F., Lambert, C. P., Cesar, D., Hellerstein, M., & Evans, W. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00352.2001 · Cited by 293
Effects of stretch‐activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse
Yeung, E. W., Whitehead, N. P., Suchyna, T. M., Gottlieb, P. A., Sachs, F., & Allen, D. G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.075275 · Cited by 271
Metadata
- Authors
- Newham, D. J., Jones, D. A., & Edwards, R. H. T.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 1983-06
- Volume
- 6
- Issue
- 5
- Pages
- 380-385
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W1964773537
- Cited by
- 272
- References
- 17
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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