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Myopathy with thick filament (myosin) loss following prolonged paralysis with vecuronium during steroid treatment
Abstract
A 20‐year‐old female hospitalized with status asthmaticus was treated with bronchodilators, antibiotics, and high‐dose corticosteroids, and was paralyzed with vecuronium for 10 days to facilitate mechanical ventilation. When this was discontinued, she was found to have a flaccid quadriplegia with areflexia and 4‐fold elevation in serum creatine kinase. A muscle biopsy showed extensive loss of thick (myosin) myofilaments, sometimes in corelike distribution, with relative preservation of thin (actin) filaments and Z‐discs. Muscle strength returned to normal after 2 months. The pathological lesion in this patient's muscle fibers resemble those in rats treated with high doses of corticosteroids following denervation.
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Citations
Cited by
Neuromuscular manifestations of critical illness
Bolton, C. F. (2005) · Muscle & Nerve · doi:10.1002/mus.20304 · Cited by 411
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
Gainnier, M., Roch, A., Forel, J.-M., Thirion, X., Arnal, J.-M., Donati, S., & Papazian, L. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000104114.72614.bc · Cited by 349
Muscular weakness and muscle wasting in the critically ill
Schefold, J. C., Wollersheim, T., Grunow, J. J., Luedi, M. M., Z'Graggen, W. J., & Weber‐Carstens, S. (2020) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12620 · Cited by 193
Puig-Vilanova, E., Rodriguez, D. A., Lloreta, J., Ausin, P., Pascual-Guardia, S., Broquetas, J., Roca, J., Gea, J., & Barreiro, E. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.006 · Cited by 167
Metadata
- Authors
- Danon, M. J., & Carpenter, S.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 1991-11
- Volume
- 14
- Issue
- 11
- Pages
- 1131-1139
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2075242275
- Cited by
- 236
- References
- 0
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Myopathy with thick filament (myosin) loss following prolonged paralysis with vecuronium during steroid treatment. https://app.cochat.ai/papers/10.1002/mus.880141115
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- Danon, M. J., & Carpenter, S. (1991). Myopathy with thick filament (myosin) loss following prolonged paralysis with vecuronium during steroid treatment. Muscle & Nerve. https://doi.org/10.1002/mus.880141115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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