Role of p38 MAP kinase signaling pathways in storage and voiding dysfunction in mice with spinal cord injury
Abstract
Aim: To investigate the role of p38 MAP kinase in lower urinary tract dysfunction in mice with spinal cord injury (SCI). Methods: Cystometry and external urethral sphincter‐electromyography were performed under an awake condition in 4‐week SCI female mice. Two weeks after SCI, a catheter connected to an osmotic pump filled with a p38 mitogen‐activated protein kinase (MAPK) inhibitor or artificial cerebrospinal fluid (CSF) was implanted into the intrathecal space of L6‐S1 spinal cord for continuous intrathecal instillation at infusion rate of 0.51 μL/h for 2 weeks before the urodynamic study. L6 dorsal root ganglia were then removed from CSF and p38 MAPK inhibitor‐treated SCI mice as well as from CSF‐treated normal (spinal intact) mice to evaluate the levels of transient receptor potential cation channel subfamily V member 1 (TRPV1), tumor necrosis factor‐α (TNF‐α), and inducible nitric oxide synthase (iNOS) transcripts by real‐time polymerase chain reaction. Results: In p38 MAPK inhibitor‐treated SCI mice, nonvoiding contractions during bladder filling, bladder capacity, and post‐void residual volume were significantly reduced while micturition pressure and voiding efficiency were significantly increased in comparison to these measurements in CSF‐treated SCI mice. The expression of TRPV1, TNF‐α, and iNOS messenger RNA was increased in SCI mice compared with expression in spinal intact mice and significantly decreased after p38 MAPK inhibitor treatment. Conclusions: The p38 MAPK signaling pathway in bladder sensory neurons or in the spinal cord plays an important role in storage and voiding problems such as detrusor overactivity and inefficient voiding after SCI.
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Telehealth can be appropriate and effective for overactive bladder follow-up and medication management.
“overactive bladder follow-up and medication management”
From Evidence for the Appropriate Use of Telemedicine in Female Pelvic Medicine and Reconstructive Surgery (2021) · cites this paper as [24]
Available data suggest that OAB care may be more cost-effective if the first visit is in person, while remote follow-up for first- and second-line therapy is probably safe and may enhance adherence and progression to third-line treatment.
“The available data suggests that care may be more cost-effective when the initial consultation is in-person, but follow-up for first- and second-line therapy is likely safe and may improve adherence to care and progression to third-line treatment.”
From Evidence for the Appropriate Use of Telemedicine in Female Pelvic Medicine and Reconstructive Surgery (2021) · cites this paper as [24]
For OAB/UUI, the first assessment may be more cost-effective in person, whereas later telehealth follow-up may improve medication adherence and increase progression to third-line treatment.
“The initial evaluation of OAB/UUI may be more cost-effective when performed in person, but subsequent telehealth follow-up may improve adherence to medication management and increase rates of progression to third-line therapy.”
From Evidence for the Appropriate Use of Telemedicine in Female Pelvic Medicine and Reconstructive Surgery (2021) · cites this paper as [24]
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- Authors
- Shimizu, N., Wada, N., Shimizu, T., Suzuki, T., Kurobe, M., Kanai, A. J., de Groat, W. C., Hashimoto, M., Hirayama, A., Uemura, H., & Yoshimura, N.
- Affiliations
- University of Pittsburgh (US)
- Department of Pharmacology and Chemical Biology University of Pittsburgh Pittsburgh Pennsylvania
- Kindai University (JP)
- Kindai University Nara Hospital (JP)
- Corresponding author
- Yoshimura, Naoki
- ORCID
- Venue
- Neurourology and Urodynamics
- Publisher
- Wiley
- Published
- 2019-10-03
- Volume
- 39
- Issue
- 1
- Pages
- 108-115
- ISSN
- 0733-2467 (ISSN-L)
- 1520-6777
- OpenAlex
- W2751847595
- Cited by
- 16
- References
- 24
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurourology and Urodynamics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense (W81XWH‐17‐1‐0403)
- Foundation for the National Institutes of Health (NIH P01 DK093424)
- Topics
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Keywords
- p38 MAPK, spinal cord injury, lower urinary tract dysfunction, voiding dysfunction, detrusor overactivity, dorsal root ganglia, TRPV1, TNF-α, inducible nitric oxide synthase, micturition pressure, post-void residual urine
- MeSH terms
- Animals, Urinary Bladder, Electromyography, Female, Mice, Inbred C57BL, Spinal Cord Injuries, Tumor Necrosis Factor-alpha, Urethra, Urination Disorders, Urodynamics, MAP Kinase Signaling System, Protein Kinase Inhibitors, p38 Mitogen-Activated Protein Kinases, TRPV Cation Channels, Mice, Nitric Oxide Synthase Type II
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