The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
Abstract
The aim of this study was to investigate the occurrence of (pre)neoplastic lesions in overtly normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The presence of (pre)neoplastic lesions was scored in histological specimens from 12 women with a genetically determined predisposition for ovarian cancer, of whom seven tested positive for a germline BRCA1 mutation. A control group included 13 women. Immunohistochemistry was used to determine the expression of p21, p27, p53, cyclin A, cyclin D1, bcl‐2, Ki67, HER‐2/neu, and the oestrogen and progesterone receptors. Loss of heterozygosity (LOH) analysis on the BRCA1 locus was also assessed on dysplastic tissue by PCR studies. Of the 12 women with a predisposition for ovarian cancer, six showed dysplasia, including one case of severe dysplasia. Five harboured hyperplastic lesions and in one woman no histological aberrations were found in the Fallopian tube. No hyperplastic, dysplastic or neoplastic lesions were detected in the Fallopian tubes of control subjects. In the cases studied, morphologically normal tubal epithelium contained a higher proportion of Ki67‐expressing cells (p=0.005) and lower fractions of cells expressing p21 (p<0.0001) and p27 (p=0.006) than in the control group. Even higher fractions of proliferating cells were found in dysplastic areas (p=0.07) and accumulation of p53 was observed in the severely dysplastic lesion. Expression patterns of other proteins studied, including the hormone receptors, were similar in cases and controls. One subject, a germline BRCA1 mutation carrier, showed loss of the wild‐type BRCA1 allele in the severely dysplastic lesion. In conclusion, the Fallopian tubes of women predisposed to developing ovarian cancer frequently harbour dysplastic changes, accompanied by changes in cell‐cycle and apoptosis‐related proteins, indicating an increased risk of developing tubal cancer. Copyright © 2001 John Wiley & Sons, Ltd.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240
Laser capture microdissection in pathology: Figure 1
Fend, F., & Raffeld, M. (2000) · Journal of Clinical Pathology · doi:10.1136/jcp.53.9.666 · Cited by 275
Primary carcinoma of the Fallopian tube
Hu, C. Y., Taymor, M. L., & Hertig, A. T. (1950) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(50)90341-3 · Cited by 273
van Diest, P. J., van Dam, P., Henzen-Logmans, S. C., Berns, E., van der Burg, M. E., Green, J., & Vergote, I. (1997) · Journal of Clinical Pathology · doi:10.1136/jcp.50.10.801 · Cited by 196
Self-citationMolecular Evidence Linking Primary Cancer of the Fallopian Tube to BRCA1 Germline Mutations
Zweemer, R. P., van Diest, P. J., Verheijen, R. H. M., Ryan, A., Gille, J. J. P., Sijmons, R. H., Jacobs, I. J., Menko, F. H., & Kenemans, P. (2000) · Gynecologic Oncology · doi:10.1006/gyno.1999.5623 · Cited by 191
Self-citationBcl-2 and p53 Protein Expression, Apoptosis, and p53 Mutation in Human Epithelial Ovarian Cancers
Chan, W.-Y., Cheung, K.-K., Schorge, J. O., Huang, L.-W., Welch, W. R., Bell, D. A., Berkowitz, R. S., & Mok, S. C. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64744-x · Cited by 171
Schubert, E. L., Lee, M. K., Mefford, H. C., ARGONZA, R. H., Morrow, J. E., Hull, J., Dann, J. L., & King, M. (1997) · PubMed · Cited by 166
Werness, B. A., Afify, A. M., Bielat, K. L., Eltabbakh, G. H., Piver, M. S., & Paterson, J. M. (1999) · Human Pathology · doi:10.1016/s0046-8177(99)90269-1 · Cited by 113
Obstetrical and Gynaecological Pathology
Haines, M., Taylor, C. W., & Fox, H. (1995) · Medical Entomology and Zoology · Cited by 85
Emerging roles of BRCA1 in transcriptional regulation and DNA repair
Chen, Y., Lee, W., & Chew, H. K. (1999) · Journal of Cellular Physiology · Cited by 81
Bcl-2 Slowsin VitroBreast Cancer Growth Despite Its Antiapoptotic Effect
Knowlton, K., Mancini, M., Creason, S. A., et al. (1998) · Journal of Surgical Research · doi:10.1006/jsre.1998.5277 · Cited by 64
Ménard, S., Casalini, P., Tomasic, G., Pilotti, S., Cascinelli, N., Bufalino, R., Perrone, F., Longhi, C., Rilke, F. O., & COLNAGHI, M. I. (1999) · Breast Cancer Research and Treatment · doi:10.1023/a:1006262324959 · Cited by 49
Hartley, A. G. J., Rollason, T. P., & Spooner, D. A. (2000) · Clinical Oncology · doi:10.1007/s001740050011 · Cited by 33
p53 protein accumulation and p53 gene mutation in colorectal cancer
Nasierowska-Guttmejer, A. M., Trzeciak, L., Nowacki, M. P., & Ostrowski, J. (2000) · Pathology & Oncology Research · doi:10.1007/bf03187331 · Cited by 20
Steroid receptors study in breast carcinoma
Lee, Y. N., & Markland, F. S. (1978) · Medical and Pediatric Oncology · doi:10.1002/mpo.2950050122 · Cited by 9
Cited by
Colombo, N., Sessa, C., du Bois, A., Ledermann, J., McCluggage, W. G., McNeish, I., Morice, P., Pignata, S., Ray-Coquard, I., Vergote, I., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz062 · Cited by 1,197
Medeiros, F., Muto, M. G., Lee, Y., Elvin, J. A., Callahan, M. J., Feltmate, C., Garber, J. E., Cramer, D. W., & Crum, C. P. (2006) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000180854.28831.77 · Cited by 916
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Kopper, O., de Witte, C. J., Lõhmussaar, K., Valle-Inclan, J. E., Hami, N., Kester, L., Balgobind, A. V., Korving, J., Proost, N., Begthel, H., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0422-6 · Cited by 834
Self-citationNew Insights Into the Pathogenesis of Serous Ovarian Cancer and Its Clinical Impact
Levanon, K., Crum, C., & Drapkin, R. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.1107 · Cited by 412
Soong, T. R., Howitt, B. E., Horowitz, N., Nucci, M. R., & Crum, C. P. (2019) · Gynecologic Oncology · doi:10.1016/j.ygyno.2018.11.033 · Cited by 110
Metadata
- Authors
- Piek, J. M. J., van Diest, P. J., Zweemer, R. P., Jansen, J. W., Poort‐Keesom, R. J. J., Menko, F. H., Gille, J. J. P., Jongsma, A. P. M., Pals, G., Kenemans, P., & Verheijen, R. H. M.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2001-10-19
- Volume
- 195
- Issue
- 4
- Pages
- 451-456
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2041634324
- Cited by
- 787
- References
- 15
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
