The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome
Abstract
A proportion of adenocarcinomas in prophylactic adnexectomies (bilateral salpingo-oophorectomies [BSOs]) from women with BRCA mutations (BRCA positive) occur in the fallopian tube. We analyzed a consecutive series of BSOs from BRCA-positive women following an index case of fimbrial serous carcinoma. To determine if the fimbria is a preferred site of origin, we followed a protocol for Sectioning and Extensively Examining the FIMbria (SEE-FIM). Immunostaining for p53 and Ki-67 was also performed. Thirteen BRCA-positive women (cases) and 13 women undergoing BSOs for other disorders (controls) were studied. Tubal carcinoma was detected in 4 cases at the initial histologic evaluation and in no controls. A fifth carcinoma was discovered following further sectioning of the fimbriae. Three were BRCA2 positive and two BRCA1 positive. Three were in the fimbria, one in both the fimbria and proximal tube, and one involved the ampulla. Four were serous carcinomas, four were confined to the tube, and three were noninvasive (intraepithelial). No ovarian carcinomas were identified. All tumors were Ki-67 positive (>75% of cell nuclei), and excluding one endometrioid carcinoma, p53 positive (>75% cell nuclei); p53 positivity in the absence of elevated Ki-67 did not correlate with morphologic neoplasia. The fimbria was the most common location for early serous carcinoma in this series of BRCA-positive women. Protocols that extensively examine the fimbria (SEE-FIM) will maximize the detection of early tubal epithelial carcinoma in patients at risk for ovarian cancer. Investigative strategies targeting the fimbriated end of the fallopian tube should further define its role in the pathogenesis of familial and sporadic ovarian serous carcinomas.
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Cites
Shih, I.-M., & Kurman, R. J. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63708-x · Cited by 1,206
Piek, J. M. J., van Diest, P. J., Zweemer, R. P., Jansen, J. W., Poort‐Keesom, R. J. J., Menko, F. H., Gille, J. J. P., Jongsma, A. P. M., Pals, G., Kenemans, P., et al. (2001) · The Journal of Pathology · doi:10.1002/path.1000 · Cited by 787
Powell, C. B., Kenley, E., Chen, L.-M., Crawford, B., McLennan, J., Zaloudek, C., Komaromy, M., Beattie, M., & Ziegler, J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.109 · Cited by 372
Colgan, T. J., Murphy, J., Cole, D. E. C., Narod, S., & Rosen, B. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200110000-00009 · Cited by 327
Pathologic Findings in Prophylactic Oophorectomy Specimens in High-Risk Women
Leeper, K., Garcia, R., Swisher, E., Goff, B., Greer, B., & Paley, P. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2002.6779 · Cited by 292
Paley, P. J., Swisher, E. M., Garcia, R. L., Agoff, S. N., Greer, B. E., Peters, K. L., & Goff, B. A. (2001) · Gynecologic Oncology · doi:10.1006/gyno.2000.6071 · Cited by 189
Occult Ovarian Tumors in Women With BRCA1 or BRCA2 Mutations Undergoing Prophylactic Oophorectomy
Lu, K. H., Garber, J. E., Cramer, D. W., Welch, W. R., Niloff, J., Schrag, D., Berkowitz, R. S., & Muto, M. G. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.14.2728 · Cited by 180
Self-citationIntraperitoneal serous adenocarcinoma: A critical appraisal of three hypotheses on its cause
Piek, J. M. J., Kenemans, P., & Verheijen, R. H. M. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.02.067 · Cited by 115
Unexpected Gynecologic Neoplasms in Patients With Proven or Suspected BRCA-1 or -2 Mutations
Agoff, S. N., Mendelin, J. E., Grieco, V. S., & Garcia, R. L. (2002) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200202000-00003 · Cited by 102
Tumors of the Fimbriated End of the Fallopian Tube
Alvarado‐Cabrero, I., Navani, S. S., Young, R. H., et al. (1997) · International Journal of Gynecological Pathology · doi:10.1097/00004347-199707000-00001 · Cited by 97
Cited by
Matulonis, U. A., Sood, A. K., Fallowfield, L., Howitt, B. E., Sehouli, J., & Karlan, B. Y. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.61 · Cited by 1,362
High grade serous ovarian carcinomas originate in the fallopian tube
Labidi-Galy, S. I., Papp, E., Hallberg, D., Niknafs, N., Adleff, V., Noe, M., Bhattacharya, R., Novak, M., Jones, S., Phallen, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00962-1 · Cited by 759
Perets, R., Wyant, G. A., Muto, K. W., Bijron, J. G., Poole, B. B., Chin, K. T., Chen, J. Y. H., Ohman, A. W., Stepule, C. D., Kwak, S., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.013 · Cited by 596
The distal fallopian tube: a new model for pelvic serous carcinogenesis
Crum, C. P., Drapkin, R., Miron, A., Ince, T. A., Muto, M., Kindelberger, D. W., & Lee, Y. (2007) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328011a21f · Cited by 512
Self-citationCallahan, M. J., Crum, C. P., Medeiros, F., Kindelberger, D. W., Elvin, J. A., Garber, J. E., Feltmate, C. M., Berkowitz, R. S., & Muto, M. G. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.2622 · Cited by 485
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Metadata
- Authors
- Medeiros, F., Muto, M. G., Lee, Y., Elvin, J. A., Callahan, M. J., Feltmate, C., Garber, J. E., Cramer, D. W., & Crum, C. P.
- Venue
- American Journal of Surgical Pathology
- Published
- 2006-02
- Volume
- 30
- Issue
- 2
- Pages
- 230-236
- ISSN
- 0147-5185 (ISSN-L)
- OpenAlex
- W2007269627
- Cited by
- 916
- References
- 11
- FWCI
- 15.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Medeiros, F., Muto, M. G., Lee, Y., Elvin, J. A., Callahan, M. J., Feltmate, C., Garber, J. E., Cramer, D. W., & Crum, C. P. (2006). The Tubal Fimbria Is a Preferred Site for Early Adenocarcinoma in Women With Familial Ovarian Cancer Syndrome. American Journal of Surgical Pathology. https://doi.org/10.1097/01.pas.0000180854.28831.77
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
