Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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CpG-rich islands and the function of DNA methylation

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Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents

Esteller, M., Garcia-Foncillas, J., Andion, E., Goodman, S. N., Hidalgo, O. F., Vanaclocha, V., Baylin, S. B., & Herman, J. G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011093431901 · Cited by 2,224

A gene hypermethylation profile of human cancer.

Esteller, M., Corn, P. G., Baylin, S. B., & Herman, J. G. (2001) · PubMed · Cited by 2,032

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

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Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

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Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Herman, J. G., Umar, A., Polyak, K., Graff, J. R., Ahuja, N., Issa, J.-P. J., Markowitz, S., Willson, J. K. V., Hamilton, S. R., Kinzler, K. W., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6870 · Cited by 1,887

Cytosine methylation and the ecology of intragenomic parasites

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Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

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Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

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Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

Kane, M., Loda, M. F., Gaida, G. M., Lipman, J., Mishra, R., Goldman, H., Jessup, J. M., & Kolodner, R. D. (1997) · PubMed · Cited by 1,476

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

Herman, J. G., Merlo, A. U., Mao, L., Lapidus, R. G., Issa, J. J., Davidson, N. E., Sidransky, D., & Baylin, S. B. (1995) · PubMed · Cited by 1,341

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Esteller, M., Hamilton, S. R., Burger, P. C., Baylin, S. B., & Herman, J. G. (1999) · PubMed · Cited by 1,253

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

Esteller, M. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.7.564 · Cited by 1,233 · cited 1×

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

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Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

Dammann, R., Li, C., Yoon, J.-H., Chin, P. L., Bates, S., & Pfeifer, G. P. (2000) · Nature Genetics · doi:10.1038/77083 · Cited by 1,064

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

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DNA hypomethylation leads to elevated mutation rates

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Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

Baylin, S. B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.687 · Cited by 929

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

Esteller, M., Sánchez‐Céspedes, M., Rosell, R., Sidransky, D., Baylin, S. B., & Herman, J. G. (1999) · PubMed · Cited by 921

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

Robertson, K. D., Uzvolgyi, E., Liang, G., Talmadge, C., Sumegi, J., Gonzales, F. A., & Jones, P. A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.11.2291 · Cited by 853

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

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Growing Y-junction carbon nanotubes

Li, J., Papadopoulos, C., & Xu, J. (1999) · Nature · doi:10.1038/46214 · Cited by 818

Predicting lung cancer by detecting aberrant promoter methylation in sputum.

Palmisano, W. A., Divine, K. K., Saccomanno, G., Gilliland, F. D., Baylin, S. B., Herman, J. G., & Belinsky, S. A. (2000) · PubMed · Cited by 816

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

Graff, J. R., Herman, J. G., Lapidus, R. G., Chopra, H., Xu, R., Jarrard, D. F., Isaacs, W. B., Pitha, P. M., Davidson, N. E., & Baylin, S. B. (1995) · PubMed · Cited by 796

The DNA methylation paradox

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

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DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

De Smet, C., Lurquin, C., Lethé, B., Martelange, V., & Boon, T. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7327 · Cited by 598

Mutations truncating the EP300 acetylase in human cancers

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Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

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Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

Herman, J. G., Jen, J., Merlo, A. U., & Baylin, S. B. (1996) · PubMed · Cited by 571

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

Esteller, M., Toyota, M., Sánchez‐Céspedes, M., Capellá, G., Peinado, M. A., Watkins, D. N., Issa, J. J., Sidransky, D., Baylin, S. B., & Herman, J. G. (2000) · PubMed · Cited by 542

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

Esteller, M., Sparks, A. B., Toyota, M., Sánchez‐Céspedes, M., Capellá, G., Peinado, M. A., González, S., Tarafa, G., Sidransky, D., Meltzer, S. J., et al. (2000) · PubMed · Cited by 536

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

Gibbons, R. J., McDowell, T. L., Raman, S., O'Rourke, D. M., Garrick, D., Ayyub, H., & Higgs, D. R. (2000) · Nature Genetics · doi:10.1038/74191 · Cited by 495

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

Esteller, M., Levine, R., Baylin, S. B., Ellenson, L. H., & Herman, J. G. (1998) · Oncogene · doi:10.1038/sj.onc.1202178 · Cited by 493

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

Ottaviano, Y. L., Issa, J. J., Parl, F. F., Smith, H. S., Baylin, S. B., & Davidson, N. E. (1994) · PubMed · Cited by 481

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

Sakai, T., Toguchida, J., Ohtani, N., Yandell, D. W., Rapaport, J. M., & Dryja, T. P. (1991) · PubMed · Cited by 466

Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

Esteller, M., Tórtola, S., Toyota, M., Capellá, G., Peinado, M. A., Baylin, S. B., & Herman, J. G. (2000) · PubMed · Cited by 465

Expression of DNA methyltransferases DNMT1,3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

Mizuno, S.-I., Chijiwa, T., Okamura, T., Akashi, K., Fukumaki, Y., Niho, Y., & Sasaki, H. (2001) · Blood · doi:10.1182/blood.v97.5.1172 · Cited by 438

Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours

Agathanggelou, A., Honorio, S., Macartney, D. P., Martinez, A., Dallol, A., Rader, J., Fullwood, P., Chauhan, A., Walker, R., Shaw, J. A., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204175 · Cited by 376

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

Fleisher, A. S., Esteller, M., Wang, S., Tamura, G., Suzuki, H., Yin, J., Zou, T., Abraham, J. M., Kong, D., Smolinski, K. N., et al. (1999) · PubMed · Cited by 368

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.

Wong, A. K., Shanahan, F., Chen, Y., Lian, L., Ha, P. C., Hendricks, K., Ghaffari, S. R., Iliev, D., Penn, B., Woodland, A.-M., et al. (2000) · PubMed · Cited by 364

Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia.

Esteller, M., Corn, P. G., Ureña, J. M., Gabrielson, E. W., Baylin, S. B., & Herman, J. G. (1998) · PubMed · Cited by 356

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

Robertson, K. D., & Jones, P. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6457 · Cited by 352

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

Katzenellenbogen, R. A., Baylin, S. B., & Herman, J. G. (1999) · Blood · doi:10.1182/blood.v93.12.4347 · Cited by 345

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

Ahrendt, S. A., Chow, J. T., Xu, L.-H., Yang, S. C., Eisenberger, C. F., Esteller, M., Herman, J. G., Wu, L., Decker, P. A., Jen, J., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.4.332 · Cited by 345

Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.

Esteller, M., Risques, R. A., Toyota, M., Capellá, G., Moreno, V. R., Peinado, M. A., Baylin, S. B., & Herman, J. G. (2001) · PubMed · Cited by 323

Hypermethylation of the Death-Associated Protein (DAP) Kinase Promoter and Aggressiveness in Stage I Non-Small-Cell Lung Cancer

Tang, X. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.18.1511 · Cited by 314

hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial Tumorigenesis

Esteller, M., Catasus, L., Matias-Guiu, X., Mutter, G. L., Prat, J., Baylin, S. B., & Herman, J. G. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65492-2 · Cited by 304

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

Corn, P. G., Kuerbitz, S. J., van Noesel, M. M., Esteller, M., Compitello, N., Baylin, S. B., & Herman, J. G. (1999) · PubMed · Cited by 280

DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas

Florl, A. R., Löwer, R., Schmitz-Dräger, B. J., & Schulz, W. A. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690524 · Cited by 255

Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors.

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The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

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Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells

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Chromatin Remodeling and Leukemia: New Therapeutic Paradigms

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5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result

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Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

Esteller, M., Avizienyte, E., Corn, P. G., Lothe, R. A., Baylin, S. B., Aaltonen, L. A., & Herman, J. G. (2000) · Oncogene · doi:10.1038/sj.onc.1203227 · Cited by 179

p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2.

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Differential methylation of human LINE-1 retrotransposons in malignant cells

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Demethylation by 5-aza-2??-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor ?? gene in human colon carcinoma cells

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Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1 -encoded protein

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DNA alterations in cancer : genetic and epigenetic changes

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Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia.

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Decitabine (5-Aza-2'-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: preliminary observations.

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DNA hypomethylation in Morris hepatomas

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DNA methylation and histone acetylation of rat methionine adenosyltransferase 1A and 2A genes is tissue-specific

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development

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DNA hypomethylation and human diseases

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DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

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