The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis
Open accessAbstract
Idiopathic pulmonary fibrosis (IPF) is a progressive, usually fatal, form of interstitial lung disease characterized by failure of alveolar re‐epithelialization, persistence of fibroblasts/myofibroblasts, deposition of extracellular matrix, and distortion of lung architecture which ultimately results in respiratory failure. Clinical IPF is associated with a histopathological pattern of usual interstitial pneumonia (UIP) on surgical lung biopsy. Therapy for this disease with glucocorticoids and other immunomodulatory agents is largely ineffective and recent trials of newer anti‐fibrotic agents have been disappointing. While the inciting event(s) leading to the initiation of scar formation in UIP remain unknown, recent advances in our understanding of the mechanisms underlying both normal and aberrant wound healing have shed some light on pathogenetic mechanisms that may play significant roles in this disease. Unlike other fibrotic diseases of the lung, such as those associated with collagen vascular disease, occupational exposure, or chemotherapeutic agents, UIP is not associated with a significant inflammatory response; rather, dysregulated epithelial–mesenchymal interactions predominate. Identification of pathways crucial to fibrogenesis might offer potentially novel therapeutic targets to slow or halt the progression of IPF. This review focuses on evolving concepts of cellular and molecular mechanisms in the pathogenesis of UIP/IPF. Copyright © 2003 John Wiley & Sons, Ltd.
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Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
Gabbiani, G., Ryan, G. B., & Majno, G. (1971) · Experientia · doi:10.1007/bf02147594 · Cited by 1,485
Ziesche, R., Hofbauer, E., Wittmann, K., Petkov, V., & Block, L.-H. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910213411703 · Cited by 586
Johnston, I. D., Prescott, R. J., Chalmers, J. C., & Rudd, R. M. (1997) · Thorax · doi:10.1136/thx.52.1.38 · Cited by 205
MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis
Yoshida, K., Kuwano, K., Hagimoto, N., Watanabe, K., Matsuba, T., Fujita, M., Inoshima, I., & Hara, N. (2002) · The Journal of Pathology · doi:10.1002/path.1208 · Cited by 148
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Li, Y., Jiang, D., Liang, J., Meltzer, E. B., Gray, A., Miura, R., Wogensen, L., Yamaguchi, Y., & Noble, P. W. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102510 · Cited by 382
The transcription factor NRF2 protects against pulmonary fibrosis
Cho, H.-Y., Reddy, S. P. M., Yamamoto, M., & Kleeberger, S. R. (2004) · The FASEB Journal · doi:10.1096/fj.03-1127fje · Cited by 355
New insights into form and function of fibronectin splice variants
White, E., Baralle, F., & Muro, A. (2008) · The Journal of Pathology · doi:10.1002/path.2388 · Cited by 323
Self-citationHorowitz, J. C., Lee, D. Y., Waghray, M., Keshamouni, V. G., Thomas, P. E., Zhang, H., Cui, Z., & Thannickal, V. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306248200 · Cited by 239
Self-citationYoon, Y.-S., Kim, S.-Y., Kim, M.-J., Lim, J.-H., Cho, M.-S., & Kang, J. L. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.130 · Cited by 145
Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet
Xu, J., Mora, A. L., LaVoy, J., Brigham, K. L., & Rojas, M. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00006.2006 · Cited by 63
Inhibition of NF-κB by ACT001 reduces fibroblast activity in idiopathic pulmonary fibrosis
Jaffar, J., Glaspole, I., Symons, K., & Westall, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111471 · Cited by 45
Metadata
- Authors
- White, E. S., Lazar, M. H., & Thannickal, V. J.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2003-07-22
- Volume
- 201
- Issue
- 3
- Pages
- 343-354
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2079501680
- Cited by
- 190
- References
- 5
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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