Pulmonary fibrosis: patterns and perpetrators
Open accessAbstract
Pulmonary fibrosis occurs in a variety of clinical settings, constitutes a major cause of morbidity and mortality, and represents an enormous unmet medical need. However, the disease is heterogeneous, and the failure to accurately discern between forms of fibrosing lung diseases leads to inaccurate treatments. Pulmonary fibrosis occurring in the context of connective tissue diseases is often characterized by a distinct pattern of tissue pathology and may be amenable to immunosuppressive therapies. In contrast, idiopathic pulmonary fibrosis (IPF) is a progressive and lethal form of fibrosing lung disease that is recalcitrant to therapies that target the immune system. Although animal models of fibrosis imperfectly recapitulate IPF, they have yielded numerous targets for therapeutic intervention. Understanding the heterogeneity of these diseases and elucidating the final common pathways of fibrogenesis are critical for the development of efficacious therapies for severe fibrosing lung diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The Pdgf pathway is crucial to disease pathogenesis.
“These observations indicate that the Pdgf pathway is crucial to disease pathogenesis.”
From Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309 · see citing works
RetractedSignal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,308 · see citing works
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Walter, P., & Ron, D. (2011) · Science · doi:10.1126/science.1209038 · Cited by 5,893 · see citing works
Epithelial-mesenchymal transition and its implications for fibrosis
Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,651 · see citing works
Idiopathic Pulmonary Fibrosis: Diagnosis and Treatment: International Consensus Statement
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.2.ats3-00 · Cited by 2,620 · see citing works
King, T. E., Pardo, A., & Selman, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60052-4 · Cited by 2,194 · see citing works
Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80545-0 · Cited by 2,076 · see citing works
Selman, M., King, T. E., & Pardo, A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-2-200101160-00015 · Cited by 1,788 · see citing works
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Humphreys, B. D., Lin, S., Kobayashi, A., Hudson, T. E., Nowlin, B. T., Bonventre, J. V., Valerius, M. T., McMahon, A. P., & Duffield, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090517 · Cited by 1,447 · see citing works
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357 · see citing works
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
Yang, L., Besschetnova, T. Y., Brooks, C. R., Shah, J. V., & Bonventre, J. V. (2010) · Nature Medicine · doi:10.1038/nm.2144 · Cited by 1,333 · see citing works
A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis
Seibold, M. A., Wise, A. L., Speer, M. C., Steele, M. P., Brown, K. M., Loyd, J. E., Fingerlin, T. E., Zhang, W., Guðmundsson, G., Groshong, S. D., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1013660 · Cited by 1,203 · see citing works
Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis
Richeldi, L., Costabel, U., Selman, M., Kim, D. S., Hansell, D. M., Nicholson, A. G., Brown, K. K., Flaherty, K. R., Noble, P. W., Raghu, G., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103690 · Cited by 1,157 · see citing works
Self-citationCirculating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, R. J., Burdick, M. D., Hong, K. M., Lutz, M., Murray, L. A., Xue, Y., Belperio, J. A., Keane, M. P., & Strieter, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20997 · Cited by 1,071 · see citing works
Rock, J. R., Barkauskas, C. E., Cronce, M. J., Xue, Y., Harris, J. R., Liang, J., Noble, P. W., & Hogan, B. L. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117988108 · Cited by 1,033 · see citing works
Self-citationWillis, B. C., Liebler, J. M., Luby‐Phelps, K., Nicholson, A. G., Crandall, E. D., du Bois, R. M., & Borok, Z. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62351-6 · Cited by 953 · see citing works
The Epidemiology of Interstitial Lung Diseases
Coultas, D., Zumwalt, R., Black, W. C., & Sobonya, R. E. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.4.7921471 · Cited by 948 · see citing works
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
Liu, G., Friggeri, A., Yang, Y., Milosevic, J., Ding, Q., Thannickal, V. J., Kaminski, N., & Abraham, E. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100035 · Cited by 935 · see citing works
Adult-onset pulmonary fibrosis caused by mutations in telomerase
Tsakiri, K. D., Cronkhite, J. T., Kuan, P. J., Xing, C., Raghu, G., Weissler, J. C., Rosenblatt, R. L., Shay, J. W., & Garcia, C. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701009104 · Cited by 894 · cited 1× · see citing works
“The most common mutations identified in familial pulmonary fibrosis are those in the genes encoding telomerase ( TERT and TERC ) (18, 19).”
Barry-Hamilton, V., Spangler, R., Marshall, D., McCauley, S., Rodriguez, H. M., Oyasu, M., Mikels, A., Vaysberg, M., Ghermazien, H., Wai, C., et al. (2010) · Nature Medicine · doi:10.1038/nm.2208 · Cited by 870 · see citing works
A Pericyte Origin of Spinal Cord Scar Tissue
Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O., & Frisén, J. (2011) · Science · doi:10.1126/science.1203165 · Cited by 858 · see citing works
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T. R., Horowitz, J. C., Pennathur, S., Martinez, F. J., & Thannickal, V. J. (2009) · Nature Medicine · doi:10.1038/nm.2005 · Cited by 852 · see citing works
international consensus statement
Clements, R. V., & Simanowitz, A. (2000) · Cited by 852 · see citing works
Tager, A. M., LaCamera, P., Shea, B. S., Campanella, G. S., Selman, M., Zhao, Z., Polosukhin, V., Wain, J., Karimi-Shah, B. A., Kim, N. D., et al. (2008) · Nature Medicine · doi:10.1038/nm1685 · Cited by 823 · see citing works
Cigarette Smoking: A Risk Factor for Idiopathic Pulmonary Fibrosis
Baumgartner, K. B., Samet, J. M., Stidley, C. A., Colby, T. V., & Waldron, J. A. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001319 · Cited by 767 · see citing works
Bone marrow–derived progenitor cells in pulmonary fibrosis
Hashimoto, N., Jin, H., Liu, T., Chensue, S. W., & Phan, S. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18847 · Cited by 715 · see citing works
Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis
Chilosi, M., Poletti, V., Zamò, A., Lestani, M., Montagna, L., Piccoli, P., Pedron, S., Bertaso, M., Scarpa, A., Murer, B., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64282-4 · Cited by 708 · see citing works
Histopathologic Variability in Usual and Nonspecific Interstitial Pneumonias
FLAHERTY, K. R., Travis, W. D., Colby, T. V., Toews, G. B., Kazerooni, E. A., Gross, B. H., Jain, A. K., Strawderman, R. L., Flint, A., Lynch, J. P., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.9.2103074 · Cited by 666 · see citing works
Thomas, A. Q., Lane, K., Phillips, J., Prince, M., Markin, C., Speer, M., Schwartz, D. A., Gaddipati, R., Marney, A., Johnson, J., et al. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200112-123oc · Cited by 641 · see citing works
Methylation determines fibroblast activation and fibrogenesis in the kidney
Bechtel‐Walz, W., McGoohan, S., Zeisberg, E. M., Muller, G. A., Kalbacher, H., Salant, D. J., Müller, C. A., Kalluri, R., & Zeisberg, M. (2010) · Nature Medicine · doi:10.1038/nm.2135 · Cited by 639 · see citing works
Lung Cancer and Cryptogenic Fibrosing Alveolitis: A Population-based Cohort Study
Hubbard, R., Venn, A. J., Lewis, S., & Britton, J. R. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.1.9906062 · Cited by 637 · see citing works
The Clinical Course of Patients with Idiopathic Pulmonary Fibrosis
Martinez, F. J., Safrin, S., Weycker, D., Starko, K. M., Bradford, W. Z., King, T. E., Flaherty, K. R., Schwartz, D. A., Noble, P. W., Raghu, G., et al. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-12_part_1-200506210-00005 · Cited by 622 · see citing works
Self-citationBone marrow–derived progenitor cells in pulmonary fibrosis
Hashimoto, N., Jin, H., Liu, T., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418847 · Cited by 621 · see citing works
Thannickal, V. J., Lee, D. Y., White, E. S., Cui, Z., Larios, J. M., Chacon, R., Horowitz, J. C., Day, R. M., & Thomas, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208544200 · Cited by 606 · see citing works
Königshoff, M., Kramer, M., Balsara, N., Wilhelm, J., Amarie, O. V., Jahn, A., Rose, F., Fink, L., Seeger, W., Schaefer, L., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci33950 · Cited by 558 · see citing works
Utility of a Lung Biopsy for the Diagnosis of Idiopathic Pulmonary Fibrosis
Hunninghake, G. W., Zimmerman, M. B., Schwartz, D. A., King, T. E., Lynch, J. P., Hegele, R. G., Waldron, J. A., Colby, T. V., Müller, N. L., Lynch, D. A., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.2.2101090 · Cited by 553 · see citing works
Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis
Moeller, A., Gilpin, S. E., Ask, K., Cox, G., Cook, D., Gauldie, J., Margetts, P. J., Farkas, L., Dobranowski, J., Boylan, C., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1534oc · Cited by 513 · see citing works
Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis
Korfei, M., Ruppert, C., Mahavadi, P., Henneke, I., Markart, P., Koch, M., Lang, G., Fink, L., Bohle, R.-M., Seeger, W., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-313oc · Cited by 508 · see citing works
Inhibition and Role of let-7d in Idiopathic Pulmonary Fibrosis
Pandit, K. V., Corcoran, D. L., Yousef, H., Yarlagadda, M., Τzouvelekis, Α., Gibson, K. F., Konishi, K., Yousem, S. A., Singh, M. K., Handley, D., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200911-1698oc · Cited by 501 · see citing works
Selman, M., Mejía, M. E., & Pardo, A. (2007) · Springer eBooks · doi:10.1007/978-1-84628-326-0_6 · Cited by 500 · see citing works
Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer
Wang, Y., Kuan, P. J., Xing, C., Cronkhite, J. T., Torres, F., Rosenblatt, R. L., DiMaio, J. M., Kinch, L. N., Grishin, N. V., & Garcia, C. K. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.11.010 · Cited by 496 · see citing works
Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis
Henderson, W. R., Chi, E. Y., Ye, X., Nguyen, C., Tien, Y.-T., Zhou, B., Borok, Z., Knight, D. A., & Kahn, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001520107 · Cited by 464 · see citing works
CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury
Moore, B. B., Kolodsick, J. E., Thannickal, V. J., Cooke, K. R., Moore, T. A., Hogaboam, C. M., Wilke, C. A., & Toews, G. B. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62289-4 · Cited by 440 · see citing works
Clinical and Pathologic Features of Familial Interstitial Pneumonia
Steele, M. P., Speer, M. C., Loyd, J. E., Brown, K. K., Herron, A., Slifer, S. H., Burch, L. H., Wahidi, M. M., Phillips, J. A., Sporn, T. A., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1104oc · Cited by 432 · see citing works
Lawson, W. E., Crossno, P. F., Polosukhin, V. V., Roldan, J., Cheng, D., Lane, K. B., Blackwell, T. R., Xu, C., Markin, C. R., Ware, L. B., et al. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00382.2007 · Cited by 428 · see citing works
Meltzer, E. B., & Noble, P. W. (2008) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-3-8 · Cited by 415 · see citing works
Self-citationEpithelial-Mesenchymal Interactions in Pulmonary Fibrosis
Chapman, H. A. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142225 · Cited by 409 · see citing works
Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis
Tanjore, H., Xu, X. C., Polosukhin, V. V., Degryse, A. L., Li, B., Han, W., Sherrill, T. P., Plieth, D., Neilson, E. G., Blackwell, T. S., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0322oc · Cited by 405 · see citing works
Raghu, G., Mageto, Y. N., Lockhart, D., Schmidt, R. A., Wood, D. E., & Godwin, J. D. (1999) · CHEST Journal · doi:10.1378/chest.116.5.1168 · Cited by 401 · see citing works
Kim, K. K., Wei, Y., Szekeres, C. K., Kugler, M. C., Wolters, P. J., Hill, M. L., Frank, J. A., Brumwell, A. N., Wheeler, S. E., Kreidberg, J. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36940 · Cited by 399 · see citing works
Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44
Li, Y., Jiang, D., Liang, J., Meltzer, E. B., Gray, A., Miura, R., Wogensen, L., Yamaguchi, Y., & Noble, P. W. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102510 · Cited by 382 · see citing works
Self-citationImatinib Treatment for Idiopathic Pulmonary Fibrosis: Randomized Placebo-controlled Trial Results
Daniels, C. E., Lasky, J. A., Limper, A. H., Mieras, K., Gabor, E., & Schroeder, D. R. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200906-0964oc · Cited by 373 · see citing works
Ramos, C., Montaño, M., García, J. A., Ruiz, V., Uhal, B. D., Selman, M., & Pardo, A. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.5.4333 · Cited by 364 · see citing works
Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs
Lawson, W. E., Cheng, D., Degryse, A. L., Tanjore, H., Polosukhin, V. V., Xu, X. C., Newcomb, D. C., Jones, B. R., Roldán-Merino, J. F., Lane, K. B., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107559108 · Cited by 363 · see citing works
Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
Andersson‐Sjöland, A., de Alba, C. G., Nihlberg, K., Becerril, C., Ramı́rez, R., Pardo, A., Westergren‐Thorsson, G., & Selman, M. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.012 · Cited by 360 · see citing works
Cryptogenic fibrosing alveolitis and lung cancer.
Turner-Warwick, M. E. H., Lebowitz, M. D., Burrows, B. A., & Johnson, A. (1980) · Thorax · doi:10.1136/thx.35.7.496 · Cited by 348 · see citing works
Cell proliferation and migration on collagen substrata in vitro
Schor, S. L. (1980) · Journal of Cell Science · doi:10.1242/jcs.41.1.159 · Cited by 345 · see citing works
Gene Expression Profiles of Acute Exacerbations of Idiopathic Pulmonary Fibrosis
Konishi, K., Gibson, K. F., Lindell, K. O., Richards, T. J., Zhang, Y., Dhir, R., Bisceglia, M., Gilbert, S., Yousem, S. A., Song, J. W., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200810-1596oc · Cited by 334 · see citing works
Scotton, C. J., Krupiczojc, M. A., Königshoff, M., Mercer, P. F., Lee, G., Kaminski, N., Morser, J., Post, J. M., Maher, T. M., Nicholson, A. G., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci33288 · Cited by 318 · see citing works
Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis
Degryse, A. L., Tanjore, H., Xu, X. C., Polosukhin, V. V., Jones, B. R., McMahon, F. B., Gleaves, L. A., Blackwell, T. S., & Lawson, W. E. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00026.2010 · Cited by 314 · see citing works
Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease
Mehrad, B., Burdick, M. D., Zisman, D. A., Keane, M. P., Belperio, J. A., & Strieter, R. M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.149 · Cited by 255 · see citing works
Jordana, M., Schulman, J., McSharry, C. P., Irving, L. B., Newhouse, M. T., Jordana, G., & Gauldie, J. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.3.579 · Cited by 233 · see citing works
WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis
Vuga, L. J., Ben‐Yehudah, A., Kovkarova-Naumovski, E., Oriss, T. B., Gibson, K. F., Feghali‐Bostwick, C. A., & Kaminski, N. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0201oc · Cited by 215 · see citing works
Li, M., Krishnaveni, M. S., Li, C., Zhou, B., Xing, Y., Banfalvi, A., Li, A., Lombardi, V., Akbari, O., Borok, Z., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42090 · Cited by 213 · see citing works
Hong, X., Diebold, D., Nho, R. S., Perlman, D., Kleidon, J., Kahm, J., Avdulov, S. V., Peterson, M., Nerva, J. D., Bitterman, P. B., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080001 · Cited by 213 · see citing works
Novel therapeutic approaches for pulmonary fibrosis
Datta, A., Scotton, C. J., & Chambers, R. C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01247.x · Cited by 203 · see citing works
Inhibition of Pulmonary Fibrosis by the Chemokine IP-10/CXCL10
Tager, A. M., Kradin, R. L., LaCamera, P. P., Bercury, S. D., Campanella, G. S. V., Leary, C. P., Polosukhin, V. V., Zhao, L.-H., Sakamoto, H., Blackwell, T. S., et al. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0175oc · Cited by 199 · see citing works
Chronic Hypersensitivity Pneumonitis
Churg, A., Müller, N. L., Flint, J. D. A., et al. (2006) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000184806.38037.3c · Cited by 197 · see citing works
Interstitial lung diseases: an epidemiological overview
Demedts, M., Wells, A. U., Antó, J. M., et al. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.18s320002 · Cited by 194 · see citing works
Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis
White, E. S., Lazar, M. H., & Thannickal, V. J. (2003) · The Journal of Pathology · doi:10.1002/path.1446 · Cited by 188 · see citing works
Chambers, R. C. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707603 · Cited by 175 · see citing works
Tian, B., Lessan, K., Kahm, J., Kleidon, J., & Henke, C. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203565200 · Cited by 166 · see citing works
Fukuda, Y., Ferrans, V. J., Schoenberger, C. I., Rennard, S. I., & Crystal, R. G. (1985) · PubMed Central · Cited by 164 · see citing works
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4
Jiang, D., Liang, J., Campanella, G. S. V., Guo, R., Yu, S., Xie, T., Liu, N., Jung, Y., Homer, R., Meltzer, E. B., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38644 · Cited by 159 · see citing works
Self-citationIntegrin α4β1 Regulates Migration across Basement Membranes by Lung Fibroblasts
White, E. S., Thannickal, V. J., Carskadon, S. L., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200301-041oc · Cited by 153 · see citing works
Fischer, A., Swigris, J. J., du Bois, R. M., Lynch, D. A., Downey, G. P., Cosgrove, G. P., Frankel, S. K., Pérez, E. R. F., Gillis, J. Z., & Brown, K. K. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2009.05.001 · Cited by 148 · see citing works
Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis
Horowitz, J. C., & Thannickal, V. J. (2006) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-2006-957332 · Cited by 146 · see citing works
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor
Krenitsky, V. P., Nadolny, L., Delgado, M., Ayala, L., Clareen, S. S., Hilgraf, R., Albers, R., Hegde, S. G., D’Sidocky, N., Sapienza, J., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.12.027 · Cited by 121 · see citing works
Wnt Signaling and Pulmonary Fibrosis
Morrisey, E. E. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64271-x · Cited by 119 · see citing works
(1996) · CHEST Journal · doi:10.1378/chest.110.4_supplement.168s · Cited by 119 · see citing works
Viral infection and aging as cofactors for the development of pulmonary fibrosis
Naik, P. K., & Moore, B. B. (2010) · Expert Review of Respiratory Medicine · doi:10.1586/ers.10.73 · Cited by 114 · see citing works
MicroRNA-127 Inhibits Lung Inflammation by Targeting IgG Fcγ Receptor I
Xie, T., Liang, J., Liu, N., Wang, Q., Li, Y., Noble, P. W., & Jiang, D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101070 · Cited by 109 · see citing works
Self-citationXie, T., Liang, J., Guo, R., Liu, N., Noble, P. W., & Jiang, D. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00222.2010 · Cited by 107 · see citing works
Self-citationEpigenetic Regulation of Thy-1 by Histone Deacetylase Inhibitor in Rat Lung Fibroblasts
Sanders, Y. Y., Tollefsbol, T. O., Varisco, B. M., & Hagood, J. S. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0154oc · Cited by 106 · see citing works
Haddad, R., & Massaro, D. J. (1968) · The American Journal of Medicine · doi:10.1016/0002-9343(68)90039-9 · Cited by 106 · see citing works
Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis
Hu, B., Gharaee-Kermani, M., Wu, Z., & Phan, S. H. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.01.002 · Cited by 102 · see citing works
Fibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
Larsson, O. S., Diebold, D., Fan, D., Peterson, M., Nho, R. S., Bitterman, P. B., & Henke, C. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003220 · Cited by 101 · see citing works
Moodley, Y. P., Caterina, P., Scaffidi, A. K., Misso, N. L. A., Papadimitriou, J. M., McAnulty, R. J., Laurent, G. J., Thompson, P. J., & Knight, D. A. (2004) · The Journal of Pathology · doi:10.1002/path.1531 · Cited by 99 · see citing works
Degryse, A. L., Tanjore, H., Xu, X. C., Polosukhin, V. V., Jones, B. R., Boomershine, C. S., Ortiz, C., Sherrill, T. P., McMahon, F. B., Gleaves, L. A., et al. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00397.2010 · Cited by 91 · see citing works
Noble, P. W., & Homer, R. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f301 · Cited by 90 · see citing works
Self-citationLovgren, A. K., Kovacs, J. J., Xie, T., Potts, E. N., Li, Y., Foster, W. M., Liang, J., Meltzer, E. B., Jiang, D., Lefkowitz, R. J., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001564 · Cited by 89 · see citing works
Self-citationYamada, M., Kuwano, K., Maeyama, T., Hamada, N., Yoshimi, M., Nakanishi, Y., & Kasper, M. E. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0388-9 · Cited by 71 · see citing works
Torry, D. J., Richards, C. D., Podor, T. J., & Gauldie, J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117131 · Cited by 68 · see citing works
Idiopathic Pulmonary Fibrosis: Natural History and Prognosis
Noble, P. W. (2006) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2005.08.003 · Cited by 62 · see citing works
Self-citationDetection of Herpes Simplex Virus Type-1 in Patients with Fibrotic Lung Diseases
Lasithiotaki, I., Antoniou, K. M., Vlahava, V.-M., Karagiannis, K., Spandidos, D. A., Siafakas, N. M., & Sourvinos, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027800 · Cited by 51 · see citing works
Hyde, D. M., King, T. E., Mcdermott, T., et al. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.4.1042 · Cited by 49 · see citing works
Kropski, J. A., Lawson, W. E., & Blackwell, T. S. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00335.2011 · Cited by 46 · see citing works
Mio, T., Nagai, S., Kitaichi, M., Kawatani, A., & Izumi, T. (1992) · CHEST Journal · doi:10.1378/chest.102.3.832 · Cited by 46 · see citing works
Mechanism of Impaired Local Hyaluronan Turnover in Bleomycin-induced Lung Injury in Rat
Teder, P., & Heldin, P. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.3.2698 · Cited by 45 · see citing works
Noble, P. W. (2003) · PubMed · Cited by 44 · see citing works
Self-citationWestergren‐Thorsson, G., Sime, P. J., Jordana, M., et al. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.009 · Cited by 42 · see citing works
HHV-8 and EBV are not commonly found in idiopathic pulmonary fibrosis.
Zamò, A., Poletti, V. E., Reghellin, D., et al. (2005) · PubMed · Cited by 34 · see citing works
Antoniu, S. A., & Kolb, M. R. J. (2010) · PubMed · Cited by 30 · see citing works
The Mechanism of Exercise-Induced R-Wave Amplitude Changes in Coronary Heart Disease
Ellestad, M. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340180121022 · Cited by 23 · see citing works
Idiopathic Pulmonary Fibrosis: The Matrix Is the Message
Kolb, M. R. J., & Gauldie, J. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201107-1282ed · Cited by 12 · see citing works
Host–Environment Interactions in Exposure-Related Diffuse Lung Diseases
Brass, D. M., Wise, A. L., & Schwartz, D. A. (2008) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0028-1101270 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- King TE Jr, Pardo A, Selman M. Idiopathic pulmo- nary fibrosis. Lancet. 2011;378(9807):1949-1961.
- White ES, Lazar MH, Thannickal VJ. Pathoge- netic mechanisms in usual interstitial pneumo- nia/idiopathic pulmonary fibrosis. J Pathol. 2003; 201(3):343-354.
Cited by
Sorted by citations
Aran, D., Looney, A. P., Liu, L., Wu, E., Fong, V., Hsu, A., Chak, S., Naikawadi, R. P., Wolters, P. J., Abate, A. R., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0276-y · Cited by 4,984 · see citing works
Hogan, B. L. M., Barkauskas, C. E., Chapman, H. A., Epstein, J. A., Jain, R., Hsia, C. C. W., Niklason, L., Calle, E., Le, A., Randell, S. H., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.012 · Cited by 876 · see citing works
Self-citationMechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2014 · Cited by 874 · see citing works
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis
Bueno, M., Lai, Y.-C., Romero, Y., Brands, J., St. Croix, C. M., Kamga, C., Corey, C., Herazo-Maya, J. D., Sembrat, J., Lee, J. S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74942 · Cited by 627 · see citing works
Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis
Xie, N., Tan, Z., Banerjee, S., Cui, H., Ge, J., Liu, R.-M., Bernard, K., Thannickal, V. J., & Liu, G. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201504-0780oc · Cited by 582 · see citing works
Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424 · see citing works
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis
Hams, E., Armstrong, M. E., Barlow, J. L., Saunders, S. P., Schwartz, C., Cooke, G., Fahy, R. J., Crotty, T. B., Hirani, N., Flynn, R. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315854111 · Cited by 376 · see citing works
Conte, E., Gili, E., Fagone, E., Fruciano, M., Iemmolo, M., & Vancheri, C. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.02.014 · Cited by 368 · see citing works
Telomere dysfunction causes alveolar stem cell failure
Alder, J. K., Barkauskas, C. E., Limjunyawong, N., Stanley, S. E., Kembou, F., Tuder, R. M., Hogan, B. L. M., Mitzner, W., & Armanios, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504780112 · Cited by 339 · see citing works
Self-citationThe role of myofibroblasts in wound healing
Hinz, B. (2016) · Current Research in Translational Medicine · doi:10.1016/j.retram.2016.09.003 · Cited by 328 · see citing works
Liang, J., Zhang, Y., Xie, T., Liu, N., Chen, H., Geng, Y., Kurkciyan, A., Mena, J. M., Stripp, B. R., Jiang, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4192 · Cited by 287 · see citing works
Self-citationModeling of fibrotic lung disease using 3D organoids derived from human pluripotent stem cells
Strikoudis, A., Cieślak, A., Loffredo, L., Chen, Y.-W., Patel, N., Saqi, A., Lederer, D. J., & Snoeck, H.-W. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.077 · Cited by 242 · see citing works
Ge, J., Cui, H., Xie, N., Banerjee, S., Guo, S., Dubey, S., Barnes, S., & Liu, G. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0238oc · Cited by 166 · see citing works
Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis
Cui, H., Xie, N., Jiang, D., Banerjee, S., Ge, J., Sanders, Y. Y., & Liu, G. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0051oc · Cited by 76 · see citing works
Self-citationPAI1 mediates fibroblast-mast cell interactions in skin fibrosis
Pincha, N., Hajam, E. Y., Badarinath, K., Batta, S. P. R., Masudi, T., Dey, R., Andreasen, P., Kawakami, T., Samuel, R., George, R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99088 · Cited by 70 · see citing works
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions
Cui, H., Ge, J., Xie, N., Banerjee, S., Zhou, Y., Liu, R.-M., Thannickal, V. J., & Liu, G. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00335.2016 · Cited by 66 · see citing works
Gill, M. W., Murphy, B. J., Cheng, P. T. W., Sivaraman, L., Davis, M., & Lehman-McKeeman, L. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115885 · Cited by 41 · see citing works
Sivaraman, L., Gill, M., Nelson, D. M., & Chadwick, K. D. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115846 · Cited by 17 · see citing works
Cheung, D., Fong, A., Ding, H. T., Cabanski, C. R., Wang, J., Chen, Y., Bush, J., Harris, J. M., & Pan, L. (2021) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2021.102051 · Cited by 6 · see citing works
- Authors
- Noble, P. W., Barkauskas, C. E., & Jiang, D.
- Affiliations
- Duke University (US)
- Corresponding author
- Noble, Paul W.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-08-01
- Volume
- 122
- Issue
- 8
- Pages
- 2756-2762
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3408732
- OpenAlex
- W2116163278
- Cited by
- 595
- References
- 106
- Citations by year
- 2026: 38 · 2025: 55 · 2024: 51 · 2023: 70 · 2022: 51 · 2021: 43 · 2020: 39 · 2019: 36 · 2018: 31 · 2017: 41 · 2016: 33 · 2015: 33 · 2014: 45 · 2013: 24 · 2012: 3
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p50hl084917-05)
- School of Medicine, Duke University
- National Heart, Lung, and Blood Institute (P01HL108793, R01HL077291, P50-HL084917, R01HL060539)
- National Institute of Allergy and Infectious Diseases (AI052201, R01AI052201)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- pulmonary fibrosis, idiopathic pulmonary fibrosis, fibrosing lung disease, disease heterogeneity, immunosuppressive therapy, fibrogenesis, therapeutic target
- MeSH terms
- Animals, Humans, Mesoderm, Models, Biological, Pulmonary Alveoli, Pulmonary Fibrosis, Genetic Predisposition to Disease, Respiratory Mucosa, Idiopathic Pulmonary Fibrosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
