The DOI matches its Crossref record.
Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells
Abstract
This study sought to determine, firstly, the relative frequency of lymphocytes and macrophages and, secondly, the percentage of lymphocytes containing interferon‐γ in inflamed islets (insulitis) of patients with type 1 (insulindependent) diabetes. Autopsy pancreases of 12 patients who had died of recent‐onset type 1 diabetes and one prediabetic patient who had died of cardiomyopathy were examined immunohistochemically. In the 87 islets that were studied, the lymphocyte macrophage ratio was 9·7:1 and approximately 40 per cent of the lymphocytes contained interferon‐γ. Interferon‐γ release in the insulitis process may be involved in the pathogensis of type 1 diabetes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Van Belle, T. L., Coppieters, K. T., & Von Herrath, M. G. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2010 · Cited by 1,022
Rabinovitch, A., & Suarez-Pinzon, W. L. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00492-9 · Cited by 466
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes
Herold, K. C., Vignali, D. A. A., Cooke, A., & Bluestone, J. A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3422 · Cited by 237
Brereton, M. F., Vergari, E., Zhang, Q., & Clark, A. (2015) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415583535 · Cited by 206
Altieri, B., Grant, W. B., Della Casa, S., Orio, F., Pontecorvi, A., Colao, A., Sarno, G., & Muscogiuri, G. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1136922 · Cited by 113
Metadata
- Authors
- Foulis, A. K., McGill, M., & Farquharson, M. A.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 1991-10
- Volume
- 165
- Issue
- 2
- Pages
- 97-103
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2059704957
- Cited by
- 235
- References
- 0
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells. https://app.cochat.ai/papers/10.1002/path.1711650203
- The paper
- Foulis, A. K., McGill, M., & Farquharson, M. A. (1991). Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells. The Journal of Pathology. https://doi.org/10.1002/path.1711650203
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
