Animal models of non‐alcoholic fatty liver disease: current perspectives and recent advances

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Items 201–300 of 373

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2. Characteristics of intestinal microbiota in C57BL/6 mice with non-alcoholic fatty liver induced by high-fat diet
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3. Broccoli consumption attenuates inflammation and modulates gut microbiome composition and gut integrity-related factors in mice fed with a high-fat high-cholesterol diet
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4. Imaging Fibrogenesis in a Diet-Induced Model of Nonalcoholic Steatohepatitis (NASH)
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5. Three-Dimensional Dynamic Cell Models for Metabolic Dysfunction-Associated Steatotic Liver Disease Progression
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6. Novel insights into metabolic‐associated steatotic liver disease preclinical models
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7. Current Treatment Regimens and Promising Molecular Therapies for Chronic Hepatobiliary Diseases
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8. Long-term profile of serological biomarkers, hepatic inflammation, and fibrosis in a mouse model of non-alcoholic fatty liver disease
   Riki Toita, Jeong‐Hun Kang · 2020 · Toxicology Letters
9. The docosahexaenoic acid derivatives, diHEP-DPA and TH-DPA, synthesized via recombinant lipoxygenase, ameliorate disturbances in lipid metabolism and liver inflammation in high fat diet-fed mice
   Lifang Wang, Hack Sun Choi, Yan Su, Jung‐Hyun Ju, Sun-Yeon Heo, Jong-Jae Yi, Back Rock Oh, Yong‐Suk Jang, Jeong‐Woo Seo · 2022 · Life Sciences
10. Tricin-enriched Zizania latifolia ameliorates non-alcoholic fatty liver disease through AMPK-dependent pathways
    Bo Yoon Chang, Jin Hye Bae, Cho Young Lim, Yoon Hee Kim, Tae Young Kim, Sung Yeon Kim · 2023 · Food Science and Biotechnology
11. Multicolor Two-Photon Microscopy Imaging of Lipid Droplets and Liver Capsule Macrophages In Vivo
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12. Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP mice
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13. Pepsin-digested chicken-liver hydrolysate attenuates hepatosteatosis by relieving hepatic and peripheral insulin resistance in long-term high-fat dietary habit
    Yi‐Hsieng Samuel Wu, Yi‐Ling Lin, Wen‐Yuan Yang, Sheng‐Yao Wang, Yi‐Chen Chen · 2021 · Journal of Food and Drug Analysis
14. The effects of metformin, pioglitazone, exenatide and exercise on fatty liver in obese diabetic rats: the role of IRS-1 and SOCS-3 molecules
    Kemal Ozan Lule, Ersin Akarsu, Zeynel Abidin Sayıner, Nezihe Otay Lule, Sibel Oğuzkan Balcı, Can Demirel, Zehra Bozdağ, Murat Korkmaz, İbrahim Yilmaz · 2022 · Inflammopharmacology
15. Dihydrotrichodimerol Purified from the Marine Fungus Acremonium citrinum Prevents NAFLD by Targeting PPARα
    Jie Liu, Shuo Gao, Wanxuan Zhou, Yongyan Chen, Zhenwu Wang, Zhiping Zeng, Hu Zhou, Ting Lin · 2023 · Journal of Natural Products
16. Detrimental role of SIX1 in hepatic lipogenesis and fibrosis of non‐alcoholic fatty liver disease
    Xiaoliang Gao, Yi Chu, Weijie Wang, Wenjiao Li, Wenyao Zhang, Jiayi Cao, Xin Fu, Hui Liu, Di Chen, Daiming Fan et al. · 2023 · Liver International
17. Transcriptomics reveal a molecular signature in the progression of nonalcoholic steatohepatitis and identifies PAI‑1 and MMP‑9 as biomarkers in in vivo and in vitro studies
    Yao Zhao, Mirensha Yakufu, Chong Ma, Baicai Wang, Jian-Hua Yang, Jun-Ping Hu · 2023 · Molecular Medicine Reports
18. Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease
    Polyana Marinho, Aline Bomfim Vieira, Priscila Gomes Pereira, Kíssila Rabelo, Bianca Torres Ciambarella, Ana Lúcia Rosa Nascimento, Erika Afonso Costa Cortez, Aníbal Sanchez Moura, Fernanda Verdini Guimarães, Marco Aurélio Martins et al. · 2018 · Evidence-based Complementary and Alternative Medicine
19. From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease
    Roni F. Kunst, Marije Niemeijer, Luc J. W. van der Laan, Bart Spee, Stan F.J. van de Graaf · 2020 · Biochemical Pharmacology
20. Associations between serum trace elements and inflammation in two animal models of nonalcoholic fatty liver disease
    Giuseppina Palladini, Andrea Ferrigno, Laura Giuseppina Di Pasqua, Clarissa Berardo, Vittoria Rizzo, Stefano Perlini, Mariapia Vairetti · 2020 · PLoS ONE
21. Bioactive Compound Bisacurone in the Turmeric Extract (Turcuron) Prevents Non-alcoholic Fatty Liver Disease by Reduction of Lipogenesis
    Kuluvar Gouthamchandra, Heggar Venkataramana Sudeep, Amritha Raj, Illuri Ramanaih, Chandrappa Siddappa, Kodimule Shyamprasad · 2021 · Indian Journal of Pharmaceutical Education and Research
22. MAFLD: a ferroptotic disease
    Shaojie Cui, Jin Ye · 2025 · Trends in Molecular Medicine
23. Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
    María Martín-Grau, Vannina G. Marrachelli, Daniel Monleón · 2022 · World Journal of Hepatology
24. USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1
    Min Ming Tang, Han Cao, Yunqin Ma, Shuangshuang Yao, Xiaohui Wei, Yijiong Tan, Fang liu, Yongde Peng, Nengguang Fan · 2024 · Journal of Translational Medicine
25. Relationship between Experimental Diet in Rats and Nonalcoholic Hepatic Disease: Review of Literature
    Ayane Araújo Rodrigues, Raíssa Silva Bacelar de Andrade, Daniel Fernando Pereira Vasconcelos · 2018 · International Journal of Hepatology
26. Animal models for hepatocellular carcinoma arising from alcoholic and metabolic liver diseases
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27. CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease
    Guixin Li, Junli Zhang, Qianqian Jiang, Beibei Liu, Keshu Xu · 2020 · Life Sciences
28. Chiliadenus iphionoides Reduces Body Weight and Improves Parameters Related to Hepatic Lipid and Glucose Metabolism in a High-Fat-Diet-Induced Mice Model of NAFLD
    Gil Zandani, Sarit Anavi, Tamar Yudelevich, Abraham Nyska, Nativ Dudai, Zecharia Madar, Jonathan Gorelick · 2022 · Nutrients
29. Animal Models of Hepatocellular Carcinoma: Current Applications in Clinical Research
    F. Fornari, C. Giovannini, F. Piscaglia, L. Gramantieri · 2022 · Journal of Hepatocellular Carcinoma
30. CGplus, a standardized herbal composition ameliorates non-alcoholic steatohepatitis in a tunicamycin-induced mouse model
    Myong-Min Lee, Hyeong-Geug Kim, Sung-Bae Lee, Jin‐Seok Lee, Wonyong Kim, Seung‐Hoon Choi, Sam-Keun Lee, Chang-Kyu Byun, Pung-Mi Hyun, Chang‐Gue Son · 2018 · Phytomedicine
31. Effect of Saxagliptin, a Dipeptidyl Peptidase 4 Inhibitor, on Non-Alcoholic Fatty Liver Disease
    Lin Chen, Xiujuan Zhang, Li Rita Zhang, Dongmei Zheng · 2020 · Diabetes Metabolic Syndrome and Obesity
32. Characterizing disease progression of nonalcoholic steatohepatitis in Leptin -deficient rats by integrated transcriptome analysis
    Ping Lü, Guang Yang, Lichun Jiang, Wen He, Wanwan Wu, Lingbin Qi, Shijun Shen, Junhua Rao, Peng Zhang, Zhigang Xue et al. · 2020 · Experimental Biology and Medicine
33. Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics
    Rebecca L. Koch, James B. Stanton, Susan McClatchy, Gary A. Churchill, Steven Wesley Craig, Darian N. Williams, Mallory E. Johns, Kylah R. Chase, Dana-Leigh Thiesfeldt, Jessica C. Flynt et al. · 2024 · Redox Biology
34. Navigating liver cancer with mouse models: a comprehensive overview of HCC experimental systems
    Ga-Young Kim, Dokyung Kim, Jaehyun Jeon, Wonhyo Seo, Seol Hee Park · 2025 · Journal of Liver Cancer
35. Partial validation of a six-month high-fat diet and fructose-glucose drink combination as a mouse model of nonalcoholic fatty liver disease
    Evangelia S. Makri, Konstantinos Xanthopoulos, Panagiotis Mavrommatis-Parasidis, Eleftheria Makri, Spyros Pettas, Anastasia Tsingotjidou, Angeliki Cheva, Iris Ballaouri, Spyridon Gerou, Antonis Goulas et al. · 2024 · Endocrine
36. Integrated Ultrasound Characterization of the Diet-Induced Obesity (DIO) Model in Young Adult c57bl/6j Mice: Assessment of Cardiovascular, Renal and Hepatic Changes
    Sara Gargiulo, Virginia Barone, Denise Bonente, Tiziana Tamborrino, Giovanni Inzalaco, Lisa M. Gherardini, Eugenio Bertelli, Mario Chiariello · 2024 · Journal of Imaging
37. Adelmidrol protects against non-alcoholic steatohepatitis in mice
    Mahitab Mohamed Nageeb, Monira Ismaeil Khatab, Ahmed A. Abdelsameea, Noha Abbas Teleb · 2019 · Naunyn-Schmiedeberg s Archives of Pharmacology
38. Hepatic steatosis, a lesion reported in captive aged common marmosets
    Olga Lucía Franco-Mahecha, Sebastian E. Carrasco · 2021 · Aging Pathobiology and Therapeutics
39. An improved method for isolation and flow cytometric characterization of intrahepatic leukocytes from fatty and fibrotic liver tissues
    R. Kandhi, Bhavesh C. Variya, S. Ramanathan, S. Ilangumaran · 2022 · The Anatomical Record
40. Amino acid pattern in the liver and blood of fattening turkeys suffering from hepatic lipidosis
    Lea Middendorf, D. Radko, Kristian Düngelhoef, Erwin Sieverding, Heinrich Windhaus, Dieter Mischok, Christian Visscher · 2019 · Poultry Science
41. Analysis of piRNA expression spectra in a non‑alcoholic fatty liver disease mouse model induced by a methionine‑ and choline‑deficient diet
    Xuyang Ma, Yumei Huang, Ying Ding, Lei Shi, Xiaoling Zhong, Ming Kang, Changping Li · 2020 · Experimental and Therapeutic Medicine
42. Omeprazole and Spirulina Platensis Ameliorate Steatohepatitis in Experimental Nonalcoholic Fatty Liver Disease
    Noha A. El-Boghdady, Maher Abd EL-Nabi Kamel, Rouaina M. El-Shamy · 2020 · Metabolic Syndrome and Related Disorders
43. Hu-lu-su-pian ameliorates hepatic steatosis by regulating CIDEA expression in AKT-driven MASLD mice
    Rumeng Ren, Qi Wang, Dongjie Deng, Aoao Guo, Xin Chen, Yan Meng, Fang Ying, Guohua Zheng, Zhong Xu, Man Li et al. · 2025 · Frontiers in Pharmacology
44. Cth/Mpst double ablation results in early onset fatty liver disease in lean mice
    Antonia Katsouda, Maria I. Markou, Dimitrios Valakos, Ioannis Theodorou, Andreas Papapetropoulos · 2025 · Redox Biology
45. AGK2 and nicotinamide riboside reveal SIRT2's protective role in a diabetic–dietary rat model of NASH via deacetylation of NLRP3, LKB1, and FOXO3a and restoration of AMPK–ACC/PGC-1α–Nrf2 signaling
    Rabab S. Hamad, Waseem Ali Hasan, Elsayed A. Elmorsy, Alshaimaa Abdelkhaliq Mohammad Farrag, Mahmoud Ali Abdelaziz, Adel I. Alalawy, Humaira Parveen, Sayeed Mukhtar, Alaa Muqbil Alsirhani, Ayshah Aysh ALrashidi et al. · 2025 · International Immunopharmacology
46. EASL position paper on preclinical models of steatotic liver disease
    Suchira Gallage, Rui E. Castro, Jennifer L. Estall, Ira A. Tabas, Quentin Mark Anstee, DINA G. TINIAKOS, Gyöngyi Szabó, Jun Yu, Chantal Desdouets, Frank Tacke et al. · 2026 · Journal of Hepatology
47. Ultrasound biomicroscopy for the assessment of early-stage nonalcoholic fatty liver disease induced in rats by a high-fat diet
    Antonio Carlos Soares Pantaleão, Marcio Pinto de Castro, Krishynan Shanty Fernandes Meirelles Araujo, Carlos Frederico Ferreira Campos, André Luíz Alves da Silva, José Eduardo Ferreira Manso, João Carlos Machado · 2022 · ULTRASONOGRAPHY
48. Spirulina (Arthrospira platensis) Improved Nonalcoholic Fatty Liver Disease Characteristics and Microbiota and Did Not Affect Organ Fibrosis Induced by a Fructose-Enriched Diet in Wistar Male Rats
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49. Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
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50. The Development of Nonalcoholic Fatty Liver Disease and Metabolic Syndromes in Diet-Induced Rodent Models
    Bayan Abdulhafid Aljahdali, Adnan S. Bajaber, Doha M. Al-Nouri, Abdulrahman Alkhalifah, Shaista Arzoo, Abeer Abdullah Alasmari · 2023 · Life
51. Circulatory bone morphogenetic protein (BMP) 8B is a non-invasive predictive biomarker for the diagnosis of non-alcoholic steatohepatitis (NASH)
    Nadella Mounika, Angeera Yadav, Parul Kamboj, Sanjay Kumar Banerjee, Utpal Jyoti Deka, Savneet Kaur, Ramu Adela · 2023 · PLoS ONE
52. Effect of Jiangan‐Jiangzhi Pill on Gut Microbiota and Chronic Inflammatory Response in Rats with Non‐Alcoholic Fatty Liver
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53. Herbal formulation MIT ameliorates high-fat diet-induced non-alcoholic fatty liver disease
    Sang Hyun Ahn, Eun-Sun Yang, Hey-Rin Cho, Syng‐Ook Lee, Ki‐Tae Ha, Ki Bong Kim · 2020 · Integrative Medicine Research
54. Modeling Alcoholic Liver Disease in a Human Liver-Chip
    Janna C. Nawroth, Débora Barreiros Petrópolis, Dimitris V. Manatakis, Tengku Ibrahim Maulana, Gabriel Burchett, Katharina Schlünder, Anke Witt, Abhishek Shukla, Geraldine A. Hamilton, Ekihiro Seki et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
55. Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism
    Gianmarco Mastrogiovanni, Clare Pacini, Sofia Kakava, Robert Arnes‐Benito, Charles Richard Bradshaw, Susan E. Davies, Kourosh Saeb‐Parsy, Bon‐Kyoung Koo, Meritxell Huch · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
56. The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease
    Kotlyarova, Anna, Iskrina, Aleksandra, Kotlyarov, Stanislav · 2026 · International journal of molecular sciences
57. Single-Cell RNA Sequencing Reveals Macrophage Dynamics During MASH in Leptin-Deficient Rats
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58. Elevated miR-34a induced by lipotoxicity and inflammation mediates pathophysiological communication between hepatocytes and hepatic stellate cells in liver fibrosis
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59. Mitigation of thromboinflammation by rivaroxaban ameliorates metabolic and structural manifestations of metabolic dysfunction-associated steatohepatitis in rats: Comparison to other antithrombotic drugs.
    Basant Rageh, Marium M. Shamaa, Mahmoud A Agami, A. El-Yazbi, Ahmed Wahid · 2025 · Journal of Pharmacology and Experimental Therapeutics
60. The effects of SGLT2 inhibitors in patients with metabolic dysfunction-associated fatty liver disease; a narrative review
    Mihaela Simona Popoviciu, Lorena Păduraru, Mominur Rahman, Fatema Akter Supti, Roxana Adriana Stoica, Delia Reurean‐Pintilei, Cristina Ioana Bica, Simona Daniela Cavalu · 2024 · Journal of Mind and Medical Sciences
61. Diagnostic efficiency on ultrasound shear wave elastography in evaluation of steatosis severity for non-alcoholic fatty liver disease: a rat model
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62. Unravelling the complexities of non-alcoholic steatohepatitis: The role of metabolism, transporters, and herb-drug interactions
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63. Thiostrepton: multifaceted biological activities and its applications in treatment of inflammatory diseases
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64. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice
    Joseph A. Cichocki, Yu‐Syuan Luo, Shinji Furuya, Abhishek Venkatratnam, Kranti Konganti, Weihsueh A. Chiu, David W. Threadgill, Igor P. Pogribny, Ivan Rusyn · 2018 · Toxicological Sciences
65. Non-invasive Bioluminescence Monitoring of Hepatocellular Carcinoma Therapy in an HCR Mouse Model
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66. Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology
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67. Prenatal Exposure to Gutkha, a Globally Relevant Smokeless Tobacco Product, Induces Hepatic Changes in Adult Mice
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68. A Transcriptomic Response to Lactiplantibacillus plantarum-KCC48 against High-Fat Diet-Induced Fatty Liver Diseases in Mice
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69. Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover
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70. Portulaca oleracea Extract Modulates Diet-Dependent Neuroplasticity in a Murine Model of MCD-Induced NAFLD and Depression
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71. Loss of Mtarc1 Protects Against Steatotic Liver Disease in Mice
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72. Small proline-rich protein 1A is a novel target of peroxisome proliferator-activated receptor gamma in steatotic liver disease
    Daisuke Aibara, Kimihiko Matsusue · 2026 · Cellular Signalling
73. The Influence of a High-Cholesterol Diet and Forced Training on Lipid Metabolism and Intestinal Microbiota in Male Wistar Rats
    Yu S Sidorova, Nikita Aleksandrovich Petrov, Yu M Markova, Alexey I. Kolobanov, Sergey Nikolaevich Zorin · 2024 · International Journal of Molecular Sciences
74. Growth Performance, Dietary Energetics, Blood Metabolites, Carcass Traits, Meat Quality, and Gene Expression of Lambs Supplemented with a Polyherbal Phytogenic Additive
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75. HA-20 prevents hepatocyte steatosis in metabolic-associated fatty liver disease via regulating Ca2+ relative signalling pathways
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76. Non-alcoholic fatty liver disease - opportunities for personalized treatment and drug development
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77. Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model
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78. An Efficient Model of Non-alcoholic Fatty Liver Disease (NAFLD) Versus Current Experimental Models: Effects of Fructose, Fat, and Carbon Tetrachloride on NAFLD
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79. Non-alcoholic Fatty Liver Disease
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80. EFFECT OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) ON HEPATIC DRUG METABOLISM ENZYMES IN HUMAN
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81. Rapamycin Reverses the Hepatic Response to Diet‐Induced Metabolic Stress That Is Amplified by Aging
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82. Comparison and Characteristics of MASLD Mouse Models
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83. The Liver-brain Axis: A Three-stage Model Linking MASLD to Cognitive Impairment and Dementia
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84. Matching mouse models to specific human liver disease states by comparative functional genomics of mouse and human datasets
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85. α-Bisabolol and royal jelly differentially mitigate thioacetamide-induced hepatic fibrosis in rats associated with the inhibition of TGF-β1/FAK/α-SMA signaling
    Sara T. Elazab, Rania Essam Ali Gamal · 2024 · Food and Chemical Toxicology
86. Characterization of diet based nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in rodent models: Histological and biochemical outcomes.
    Ghaidafeh Akbari, Seyyed Ali Mard, Feryal Savari, Barat Barati, Maryam Jafar Sameri · 2022 · PubMed
87. Hepatoprotective effects of Erythrina abyssinica Lam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats
    Felix Kanyi Macharia, Peter Waweru Mwangi, Abiy Yenesew, Frederick Bukachi, Nelly Murugi Nyaga, David Kayaja Wafula · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
88. A mouse model for spinal muscular atrophy provides insights into non-alcoholic fatty liver disease pathogenesis
    Marc‐Olivier Deguise, Chantal A. Pileggi, Ariane Beauvais, Alexandra Tierney, Lucia Chehadé, Yves De Repentigny, Jean Michaud, Maica Llavero Hurtado, Douglas J. Lamont, Abdelmadjid Atrih et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
89. Performance of ATT and UDFF in the diagnosis of non-alcoholic fatty liver: An animal experiment
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90. Purple potato extract modulates fat metabolizing genes expression, prevents oxidative stress, hepatic steatosis, and attenuates high-fat diet-induced obesity in male rats
    Ishrat Jahan, Asif Ul Haque Shuvo, Mirza Alimullah, Ashiqur Rahman, Shahnaz Siddiqua, Shatil Rafia, Ferdous Khan, Khondoker Shahin Ahmed, Hemayet Hossain, Kazi Akramuddaula et al. · 2025 · PLoS ONE
91. RING Finger Protein 4 ( RNF4 ) Reduces Nonalcoholic Fatty Liver Disease Accumulation by Promoting the SUMOylation of HIF ‐2α and Regulating the PPARα Signaling Pathway
    Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jing Li et al. · 2025 · IUBMB Life
92. The importance of sex dimorphism in liver metabolism and progressive liver diseases
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93. The role of free‐fatty acid receptors FFA1 and FFA4 in organ fibrosis
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94. Comparative analysis of renal dysfunction, immune remodeling, and gut microbiota profiles in dietary models of metabolic liver disease
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95. Grading fatty liver by ultrasound time-domain radiofrequency signal analysis: an in vivo study of rats
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96. The Effects of High-Fat Diet and CCl4 Administration on Liver Function and Lipid Profile in Non-Alcoholic Fatty Liver Disease Rat Model
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