Animal models of non‐alcoholic fatty liver disease: current perspectives and recent advances

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Items 301–373 of 373

1. Longitudinal analysis of a dietary mouse model of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
   Marissa Saenz, Jillian C. McDonough, Elizabeth Bloom‐Saldana, José M. Irimia, Emily L. Cauble, Ashly Castillo, Patrick T. Fueger, Lindsey S. Treviño · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
2. Non-alcoholic Fatty Liver Disease
   Sangwon F. Kim, Jang Hyun Choi · 2023 · Springer eBooks
3. Propylthiouracil Induced Rat Model Reflects Heterogeneity Observed in Clinically Non-Obese Subjects with Nonalcoholic Fatty Liver Disease
   Yu Jin, Qiuyan Liu, Yuqin Wang, Bing Wang, Jing An, Qimeng Chen, Tao Wang, Jing Shang · 2024 · International Journal of Molecular Sciences
4. Thymidine Phosphorylase Imaging Probe for Differential Diagnosis of Metabolic dysfunction-associated Steatohepatitis
   Kei Higashikawa, Riho Uehara, Sawako Horiguchi, Yuki Shibata, Naoto Okubo, Yuki Mizuno, Hironobu Yasui, Shunsuke Ohnishi, Hiroshi Takeda, Yuji Kuge · 2024 · Molecular Imaging and Biology
5. The role of hepatic sinusoidal microenvironment in NASH: pathogenesis, animal models, and therapeutic prospects
   Wanying Tan, Jiangting Deng, Lingjun Qi, Zhenghuai Tan · 2025 · Frontiers in Pharmacology
6. Comparison of the characteristics of non-alcoholic fatty liver disease in C57BL/6J-Leprem1hwl/Korl and C57BLKS/J-Leprdb/J mice
   Seungwoo Lee, J. K. Min, Myoung Jun Kim, Somi Yun, Min Kyoung Seo, Jong Kwon Lee · 2025 · EXPERIMENTAL ANIMALS
7. Protective effect of vitamin D on high-fat-diet-induced metabolic dysfunction-associated steatotic liver disease in mice
   Amal Ahmed Mohamed, Wael Hafez, Said A. El‐Feky, Mona G. Khalil, Amina S. Soliman, Karima Nasraldin, Ingy Maher El-Hefny Ibrahim, Hanan A. Hegazy, Weam Shaheen, Abbas M. Abbas et al. · 2025 · Steroids
8. scSpecies: enhancement of network architecture alignment in comparative single-cell studies
   Clemens Schächter, Martin Treppner, Maren Hackenberg, Hanne Raum, Joschka Boedecker, Harald Binder · 2025 · Genome biology
9. Integrating biochemical and computational approaches to identify targeted therapeutic strategies for liver fibrosis: Effects of Telaglenastat (CB-839) on the glutaminase pathway
   Hoda elsayed Fakher, Eman T. Mehanna, Abdel‐Aziz A. Zidan, Noha M. Mesbah, Dina Mohamed Abo–Elmatty, Sherin Refat El Afify, Ghada M. Al‐Ashmawy · 2025 · Biochemical and Biophysical Research Communications
10. Schisandrin B inhibits hepatic inflammation and steatosis via activation of pregnane X receptor signaling in methionine and choline-deficient high fat diet-induced steatohepatitis mouse model
    Chun Yu Gu, Li Shan Yan, Lu Cheng, Zhi Shan Huang, Jia Jia Li, Wen Ling Liu, Qi Ling Tan, Hui Zhang, Yi Zhang · 2026 · International Immunopharmacology
11. Silymarin-loaded phytosomal nanoparticles mitigate dyslipidemia, oxidative damage, and hepatic injury in high-fat diet-induced metabolic dysfunction-associated steatotic liver disease in rats
    Shahad W. Kattan, ‏Amany I. Almars, Wajnat A. Tounsi, Areej Ahmed Turkistani, A M El Awady Mohamed, Mona M. Elghareeb, Ekramy M. Elmorsy, Shaymaa H.E. Ali · 2026 · BMC Gastroenterology
12. Superior inflammatory response and MASH progression in Apoe-/- mice compared to wild-type mice: a comprehensive time-course analysis
    Anja R. Geisler, Nora Meinhardt, Laura Otto, Yvonne Hupfer, Betty Hebecker, Bill J Perkowski, Markus Werner, Wan-Ting Zhao, Karl‐Heinz Herrmann, Marcus Ebert et al. · 2026 · Frontiers in Immunology
13. An integrative approach to assessing effects of a short-term Western diet on gene expression in rat liver
    Jaclyn E. Welles, Holly A. Lacko, Yuka Imamura Kawasawa, Michael Don Dennis, Leonard S. Jefferson, Scot R. Kimball · 2022 · Frontiers in Endocrinology
14. Herbal Components for the Treatment of Liver Disorders: Advances and Prospective
    Tatheer Fatima, Zeashan Hussain, Devendra Kumar Katiyar, Rishabha Malviya · 2024 · Current Nutrition & Food Science
15. Quantitative analysis of sterol balance in a mouse model of hepatic lipid accumulation induced by cholesterol and cholic acid supplementation
    Hinata Soma, Ryo Yoshida, Satoshi Ishizuka · 2024 · Bioscience Biotechnology and Biochemistry
16. Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions
    Karen R. Jonscher, Kimberley D. Bruce · 2019 · Advances in experimental medicine and biology
17. Enhancement of Network Architecture Alignment in Comparative Single-Cell Studies
    Clemens Schächter, Martin Treppner, Maren Hackenberg, Hanne Raum, Joschka Boedecker, Harald Binder · 2024 · Qeios
18. Mouse Models for NASH: Are we there yet?
    Yvonne Oligschlaeger · 2017
19. WITHDRAWN: Rodent models of fatty liver diseases
    Adeline Bertola · 2018 · Liver Research · Retracted
20. Efeitos dos diferentes ácidos graxos no metabolismo lipídico e estresse oxidativo em camundongos C57/BL alimentados com dieta hiperlipídica e rica em frutose
    Camila Sanches Manca · 2018
21. Leptin deficient rats develop nonalcoholic steatohepatitis with unique disease progression
    Ping Lü, Guang Yang, Wen He, Wanwan Wu, Lingbin Qi, Shijun Shen, Junhua Rao, Guoping Fan, Zhigang Xue, Peng Zhang et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
22. The role of cannabinoid receptor 1 in the development of oxidative/nitrosative stress in mice with non-alcoholic fatty liver disease
    Dušan Brkić, Bojan Z. Jorgačević · 2019 · Medicinski podmladak
23. METABOLIC CHARACTERIZATION OF MICE LACKING CARBONIC ANHYDRASE III
    Sarah W. Renner · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
24. Diet-induced animal models of nonalcoholic fatty liver disease
    Qingmin Zeng, Jia Li · 2019 · World Chinese Journal of Digestology
25. A Compromised Liver Alters PCB Toxicity and Nutrient Metabolism
    Jazmyne Barney · 2019 · UKnowledge (University of Kentucky)
26. A New Rodent Model of Non-Alcoholic Steatohepatitis and Metabolic Syndrome
    Fernando Gomes Romeiro, Lívia Alves Amaral Santos · 2019 · Arquivos Brasileiros de Cardiologia
27. A high fat containing chicken egg-only diet suppresses fatty liver induced by a lipid-rich methionine and choline deficient diet
    Ken‐ichi Isobe, Naomi Nishio, Ami Kuzuya, Kana Kato, Aki Hatanaka, Rena Suzuki, Miki Kawai, Aoi Kanjya, Chiaki Suitou, Yui Nakano et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
28. Development of 68Ga-labeled tin colloids for evaluating phagocytic function of Kupffer cells using preclinical PET imaging
    Yohji Matsusaka, Tadaki Nakahara, Kazuhiro Takahashi, Yu Iwabuchi, Shoki Nakamura, Masahiro Jinzaki · 2020 · Annals of Nuclear Medicine
29. Labidochromis caeruleus ve Xiphophorus hellerii de non-alkolik steatohepatitis in araştırılması
    Mustafa Ünal BOYRAZ, Muhammed Yaşar Dörtbudak, Bahıttin Dörtbudak · 2019 · Eurasian journal of veterinary sciences
30. Diosmetin modulates lipogenesis and alleviates inflammatory response in nonalcoholic steatohepatitis through STAT1/CXCL10-dependent pathway
    Nanxuan Luo, Changqing Yang, Yurong Zhu, Baoshun Zhang · 2020
31. Role and Mechanisms of Probiotics in Regulating the ROS/JNK Signaling Pathway in the Pathogenesis of Nonalcoholic Fatty Liver Disease.
    HuiYuan Xu, Leilei Yang, Yumei Huang, Chang‐Ping Li · 2021 · Research Square
32. Modelo experimental de dieta rica em gordura é útil para avaliar o agravamento dos danos ao fígado associados a comorbidades
    Ayane Araújo Rodrigues, Even Herlany Pereira Alves, Raíssa Silva Bacelar de Andrade, Luíz Felipe de Carvalho França, Larissa dos Santos Pessoa, Felipe Rodolfo Pereira da Silva, David Di Lenardo, Hélio Mateus Silva Nascimento, André dos Santos Carvalho, Francisca Beatriz de Melo Sousa et al. · 2021 · Research Society and Development
33. Modelos animales de carcinoma hepatocelular y sus aplicaciones en biomedicina
    Irati L. de la Pisa · 2021 · Ambiociencias
34. Curcumin formulated nanoparticles for hepatocellular carcinoma
    Neha Merchant, Sujatha Peela, Afroz Alam, Ganji Purnachandra Nagaraju · 2022 · Elsevier eBooks
35. Faculty Opinions recommendation of Animal Models of Nonalcoholic Fatty Liver Disease-A Starter's Guide.
    Stefano Bellentani, Natalia Rosso · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
36. Rola białka MCPIP1 w metabolizmie lipidów, utrzymaniu homeostazy wątroby oraz rozwoju niealkoholowej stłuszczeniowej choroby wątroby
    Natalia Pydyn, Jerzy Kotlinowski · 2022 · Postępy Biochemii
37. Modulación de la microbiota intestinal en el tratamiento de la enfermedad de hígado graso no alcohólico y síndrome metabólico. Estudio de un tratamiento experimental con quercetina y de la transferencia de microbiota a ratones libres de gérmenes = Intestinal microbiota modulation in the treatment of non-alcoholic fatty liver disease and metabolic syndrome. Study of an experimental treatment with quercetin and intestinal microbiota transfer to germ-free mice
    David Porras · 2021
38. Choline Chloride Encapsulated PLGA Nanoparticles Labelled with Lanthanide Metals
    Burcu Uçar · 2023 · European Journal of Science and Technology
39. Targeting one-carbon metabolism by methyl donors for prevention of non-alcoholic fatty liver in rats
    Huda Abdulaziz Al Doghaither · 2023 · The Annals of Clinical and Analytical Medicine
40. Community Series - Liver Fibrosis and MAFLD: from Molecular Aspects to Novel Pharmacological Strategies, Volume II
    2024 · Frontiers research topics
41. What does it take to make progress in a disease?
    Michael S. Ringel, Julie Dethier, Michelle J. Davitt, Maria Denslow, Robert Fowler, Sebastian C. Hasenfuss, Ulrik Schulze · 2024 · medRxiv
42. Rifaximin prophylaxis in MASLD‑hepatocellular carcinoma: Lessons from a negative animal model
    Larisse Longo, Gabriel Tayguara Silveira Guerreiro, Luiza Marques Prates Behrens, Matheus Pereira, Carlos Pinzon, Carlos Thadeu Schmidt Cerski, Carolina Uribe Cruz, Mário Reis Álvares‐da‐Silva · 2024 · Biomedical Reports
43. Antihyperlipidemic Activity of Chenopodium Album in High Carbohydrate High Fat Diet Induced Obese Rat Model
    Razina Rouf · 2025 · SSRN Electronic Journal
44. Bioactive Phytochemical–Based Nanocarriers for Targeting Non‐Alcoholic Fatty Liver Disease (NAFLD)
    Gautam Kumar, Sara Fathima, Prasada Chowdari Gurram, Chaman Bala, Rakesh Kumar Sindhu, Farmiza Begum · 2025
45. Optimization of a miniaturized microwave-assisted saponification and extraction method to evaluate mosh and MOAH in biological samples
    Paula Albendea, Aleksandra Gorska, Giorgia Purcaro · 2025 · Journal of Chromatography Open
46. Additional file 1 of Effects of riboflavin deficiency and high dietary fat on hepatic lipid accumulation: a synergetic action in the development of non-alcoholic fatty liver disease
    Yanxian Wang, Bian, Xiangyu, Wan, Min, Weiyun Dong, Gao, Weina, Yao, Zhanxin, Guo, Changjiang · 2024 · Figshare
47. Additional file 1 of USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1
    Tang, Min, Han Cao, Yunqin Ma, Yao, Shuangshuang, Wei, Xiaohui, Yijiong Tan, liu, Fang, Peng, Yongde, Fan, Nengguang · 2024 · Figshare
48. Additional file 1 of Dietary L-arginine supplementation reduces lipid accretion by regulating fatty acid metabolism in Nile tilapia (Oreochromis niloticus)
    Li, Senlin, Zhang, Yunchang, Liu, Ning, Chen, Jingqing, Guo, Lina, Dai, Zhaolai, Wang, Chao, Wu, Zhenlong, Wu, Guoyao · 2020 · Figshare
49. Additional file 2 of Effects of riboflavin deficiency and high dietary fat on hepatic lipid accumulation: a synergetic action in the development of non-alcoholic fatty liver disease
    Yanxian Wang, Bian, Xiangyu, Wan, Min, Weiyun Dong, Gao, Weina, Yao, Zhanxin, Guo, Changjiang · 2024 · Figshare
50. Additional file 1 of Phenotypic and metabolomic characteristics of mouse models of metabolic associated steatohepatitis
    Yang, Cian-Ru, Lin, Wen-Jen, Shen, Pei-Chun, 廖佩吟, Dai, Yuan-Chang, Hung, Yao-Ching, Lai, Hsueh‐Chou, Shiraz Mehmood, Cheng, Wei-Chung, Ma, Wen-Lung · 2024 · Figshare
51. Plant-Based Remedies for Nonalcoholic Fatty Liver Disease
    V. M. Ragitha, Parvathy Susheelan, P. S. Syananth, Biba Vikas, Lekshmi K. Edison · 2025 · Springer eBooks
52. Tofogliflozin attenuates liver steatosis and fibrosis in non-diabetic non-alcoholic steatohepatitis mice
    Yoshinori Ozono, Hiroshi Kawakami, Hiroshi Hatada, Naomi Uchiyama, Souichiro Ogawa, Keisuke Uchida, Hotaka Tamura, Yuri Komaki, Kenichi Nakamura, Hisayoshi Iwakiri et al. · 2026 · BMC Gastroenterology
53. Establishment and characterization of a metabolic dysfunction-associated steatotic liver disease model in the male Korean field mouse ( Apodemus peninsulae ): A comparison with the male C57BL/6J mouse
    Qing Zhang, Xiwen Zhang, Jin He, Yanzun Li, Shiqi Qiao, Yan Gao, Jinping Hu, Yujing Feng, Bao Yuan, Jie Chen et al. · 2026 · Veterinary Pathology
54. NGR1 Ameliorates Hepatocyte Steatosis and Mitochondrial Dysfunction Associated with the Restoration of NDUFS2
    Min Liu, Dongsheng Liu, Qian Zhang, Rui Zhang, Jiye Aa, Guangji Wang, Yuan Xie · 2026 · Pharmaceuticals
55. Effets de l’inflammation viscérale dans deux modèles de stéatohépatite non alcoolique (NASH) induite par la programmation foetale ou la carence en donneurs de méthyles
    Zeinab Harb · 2019
56. Rôle des cellules endothéliales dans le carcinome hépatocellulaire associé au syndrome métabolique
    Samira Laouirem · 2019
57. Role of RIPK1 in the survival and death of hepatocytes : its involvement in murine hepatitis models
    Muhammad Farooq · 2019 · theses.fr (ABES)
58. Diversité des macrophages dans un modèle murin de stéatohépatite non alcoolique
    Sophie Tran · 2019 · theses.fr (ABES)
59. Implications du microbiote intestinal et de la pectine dans la stéato-hépatite non-alcoolique
    Camille Houron · 2020
60. Rôle de REG3A dans la maladie métabolique du foie d'origine nutritionnelle
    Tung-Son Nguyen · 2024 · theses.fr (ABES)
61. Sabinineoside B alleviates metabolic dysfunction-associated steatotic liver disease by targeting PPAR α
    Yan Feng, Renhao Chen, Yiming Li, Yilei Wang, Yuwei Wang, Zhiqiang Li, Daofeng Chen, Qi Wang, Zhifeng Li · 2026 · Communications Biology
62. CD59 drives diet-induced obesity and glucose intolerance, insulin resistance, and metabolic dysfunction-associated steatotic liver disease
    Marian Zeibak, Netanel Karbian, Yael Riahi, Saja Baraghithy, Labiba Ahmad, Adi Tabib, Ifat Abromovitz, Bella Agranovitz, Hadar Benyamini, Eyal Gottlieb et al. · 2026 · npj Metabolic Health and Disease
63. Comparative Analysis of Classical and Emerging Experimental Animal Models of Liver Injury: A Comprehensive Review
    Ibtehal Nasser Salman, Roaa Khaled Jabbar, Israa Emad, Zain Al‐Abidin Ahmed Hassan, Abeer Mahdi Harbi, Aseel Yass Khudhair, Malak Ali Mohammed Hussein, Ali Majid Hamid, Mahdi Abd Al Amir, Mustafa Wafi Ali et al. · 2026 · Journal of Applied Toxicology
64. Physiologically relevant media are associated with overlapping metabolic responses in primary human hepatocytes and Huh7 cells
    Eloise Cross, Felix Westcott, K H Smith, Shilpa R. Nagarajan, Fabio Sanna, Kaitlyn M.J.H. Dennis, Leanne Hodson · 2026 · Physiological Reports
65. AI digital pathology as a key tool providing in-depth understanding of the progression and regression of MASH and fibrosis in male mouse models
    Ashmita Saigal, Desiree Abdurrachim, Emily Tso, Christopher Hendra, Charlene Z. L. Ong, Sonya Kimball, Wendy M. Blumenschein, Yang Liu, Xueyuan Jiang, Arun Jayant Sanyal et al. · 2026 · Nature Communications
66. Human placenta extract declines fat deposition in an in vitro novel 3D MASLD model
    Parisa Taheri, Fatemeh Majidi, Kosar Nouri, Masoumeh Nouri, Morteza Zarrabi, Elham Rismani, Abbas Piryaei, Massoud Vosough · 2026 · In vitro models
67. Hilpda gene expression in steatotic liver is regulated by peroxisome proliferator-activated receptor γ
    Daisuke Aibara, Takuya Yamashina, Koichi Matsuo, Kimihiko Matsusue · 2026 · Journal of Molecular Endocrinology
68. Selenium Nanoparticles Attenuate High-Fat Diet–Induced Nafld in Male Albino Rats With and Without Dietary Modification: Histopathological and Biochemical Evaluation
    Mai Kotb, Amira Madwar, Safaa Takey El Din, Sara Assem, Dina M. Rostom · 2026 · Research Square
69. The ability of FGF21 to ameliorate signs of non-alcoholic fatty liver disease in mice depends on sex and diet
    Natalia Balybina, Makarova En, Tatiana Jakovleva, A. Yu. Kazantseva, Н. М. Бажан · 2026 · Vavilov Journal of Genetics and Breeding
70. Liver-targeted DGAT2 siRNA ameliorates steatosis and fibrosis in a high-fat diet–induced MASH mouse model
    Enhua Zhang, Wei Zheng, YIZHE LI, Zihui Cheng, Ying Cai, Yong Cheng, Xiaojuan Zhang, Qiongqiong Hou, Yujie Liu, Meng Bingxue et al. · 2026 · Journal of drug targeting
71. A mitochondria-targeting dual-emissive probe for imaging hypoxia-associated biomarkers in early non-alcoholic fatty liver disease
    Xiaodong Zhou, Rongjun Gu, Yuerong Zou, Kanagaraj Rajalakshmi, Dae-Kyun Lee, Jong‐Won Song, Yun-Sik Nam, Dongwei Zhu, Selvaraj Muthusamy, Ki Young Choi et al. · 2026 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
72. BindingDB Entry 50019754: Dihydrotrichodimerol Purified from the Marine Fungus
    BindingDB · 2024 · UC San Diego
73. Hepatoprotective Effect of Nicotinamide Mononucleotide on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Mice
    Yiwen Zhang, Yafei Wu, Yanhong Wei, Xuan Liu, Xiaocan Lei, Hua Huang, Meixiang Li · 2026 · Food Science & Nutrition