The impact of non‐invasive prenatal testing on anxiety in women considered at high or low risk for aneuploidy after combined first trimester screening
Abstract
What's already known about this topic? High‐risk combined first trimester screening results may create high levels of state anxiety. This anxiety usually resolves upon receipt of a normal karyotype result through invasive testing. However, invasive testing itself provokes anxiety. What does this study add? Both high‐risk and low‐risk combined first trimester screening populations demonstrated similar trait anxiety levels and experienced a statistically significant reduction in state anxiety to similar final levels after they received a low‐risk non‐invasive prenatal testing result.
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Four included studies assessed anxiety with the Spielberger State-Trait Anxiety Inventory (STAI or short form STAI-6).
“Four studies assessed anxiety with the Spielberger State-Trait Anxiety Inventory (STAI or short form STAI-6) [20–22, 24].”
From Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review (2019) · cites this paper as [22]
Most included studies recruited women with an elevated Down syndrome screening risk, while two studies recruited from an unselected population regarding Down syndrome screening.
“Most studies recruited women with an elevated Down syndrome screening (DSS) risk (medium and/or high risk, cut-offs vary, range from > 1:1000 to 1:1–125) [20–22, 24, 25], two studies recruited from an unselected population regarding DSS [19, 23].”
From Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review (2019) · cites this paper as [22]
Five included studies assessed anxiety, psychological distress and/or decisional regret with validated psychological tests such as STAI, PRAQ-R, K6 or DRS.
“Five studies assessed anxiety, psychological distress and/or decisional regret with validated psychological tests like the Spielberger State-Trait Anxiety Inventory (STAI or short form STAI-6), the Pregnancy-Related Anxiety Questionnaire-Revised (PRAQ-R), the Kessler Psychological Distress Scale (K6) or the Decisional Regret Scale (DRS) [20–24].”
From Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review (2019) · cites this paper as [22]
The scoping review identified seven studies that investigated psychological and/or social consequences after NIPT.
“In this scoping review, we identified seven studies that investigated psychological and/or social consequences after NIPT [19–25].”
From Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review (2019) · cites this paper as [22]
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- Authors
- Richmond, Z., Fleischer, R., Chopra, M., Pinner, J., D'Souza, M., Fridgant, Y., & Hyett, J.
- Affiliations
- Royal Prince Alfred Hospital (AU)
- The University of Sydney (AU)
- Sydney Local Health District (AU)
- Fetal Medicine Unit Royal Prince Alfred Hospital Camperdown NSW Australia
- Corresponding author
- Fleischer, Ron
- Venue
- Prenatal Diagnosis
- Publisher
- Wiley
- Published
- 2017-08-14
- Volume
- 37
- Issue
- 10
- Pages
- 975-982
- ISSN
- 0197-3851 (ISSN-L)
- 1097-0223
- OpenAlex
- W2726600983
- Cited by
- 14
- References
- 22
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prenatal Diagnosis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- non-invasive prenatal testing, anxiety, state anxiety, first-trimester combined screening, aneuploidy risk, prenatal decision-making
- MeSH terms
- Adult, Aneuploidy, Anxiety, Decision Making, DNA, Female, Gestational Age, Humans, New South Wales, Pregnancy, Pregnancy Complications, Pregnancy Trimester, First, Prenatal Diagnosis, Surveys and Questionnaires, Risk Factors, Polymorphism, Single Nucleotide, Nuchal Translucency Measurement
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