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Cited by 279

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Membrane proteins and membrane proteomics

Tan, Sandra, Tan, Hwee Tong, Chung, Maxey C. M.·2008·PROTEOMICS

Abstract

Biological membranes form an essential barrier between living cells and their external environments, as well as serve to compartmentalize intracellular organelles within eukaryotes. The latter includes membranes that envelope the nucleus, the outer and inner membranes of the mitochondria, membrane cisternae complex of the ER, Golgi apparatus, as well as lysosomes and secretory vesicles. Depending on their localizations in the whole organism and also within the cell, these membranes have different, highly specialized functions. Although 30% of naturally occurring proteins are predicted to be embedded in biological membranes, membrane proteomics is traditionally understudied due to difficulties in solubilizing, separating, and identifying membrane proteins. Given the importance of membrane proteins in the various cellular processes listed in this review, as well as the roles they play in diseases and their potential as drug targets, it is imperative that this class of proteins be better studied. With the recent advancement in technology, it is expected that some of the difficulties in membrane proteomics will be overcome, yielding new data on membrane proteins.

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Crossref · 10.1002/pmic.200800597

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Metadata

Authors
Tan, S., Tan, H. T., & Chung, M. C. M.
Venue
PROTEOMICS
Publisher
Wiley
Published
2008-09-24
Volume
8
Issue
19
Pages
3924-3932
ISSN
  • 1615-9853 (ISSN-L)
  • 1615-9861
OpenAlex
W2092705888
Cited by
279
References
62
FWCI
8.02
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Membrane proteins and membrane proteomics. https://app.cochat.ai/papers/10.1002/pmic.200800597
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Tan, S., Tan, H. T., & Chung, M. C. M. (2008). Membrane proteins and membrane proteomics. PROTEOMICS. https://doi.org/10.1002/pmic.200800597

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