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Functionalized Biomimetic Magnetic Nanoparticles as Effective Nanocarriers for Targeted Chemotherapy

Peigneux, Ana, Oltolina, Francesca, Colangelo, Donato, Iglesias, Guillermo R., Delgado, Angel V., Prat, Maria, Jimenez‐Lopez, Concepcion·2019·Particle & Particle Systems Characterization
DOI 10.1002/ppsc.201900057
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Abstract

Novel MamC‐mediated biomimetic magnetic nanoparticles (BMNPs) are proposed as valuable carriers for targeted chemotherapy because of the size (36 ± 12 nm) and of surface properties conferred by MamC coating. They are super‐paramagnetic at room and body temperatures, have a large magnetic moment per particle, mediate hyperthermia, are cytocompatible, and, having a negative surface charge at physiological pH, can be efficiently coupled with DOXOrubicin (DOXO) and a monoclonal antibody (mAb) directed against the human Met/hepatocyte growth factor receptor (overexpressed in many cancers) displaying coupling stability, while releasing DOXO at acidic pH. This release can be enhanced by hyperthermia. The DOXO‐mAb‐BMNPs selectively recognize Met, bind efficiently to Met+ tumor cells, and discharge DOXO within their nuclei more efficiently than DOXO‐BMNPs, exerting cytotoxicity. These data represent proof of concept for future in vivo experiments in which the controlled dual targeting (mAb‐mediated and magnetic) approach and combined (chemotherapy and hyperthermia) therapy will be studied.

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Metadata

Authors
Peigneux, A., Oltolina, F., Colangelo, D., Iglesias, G. R., Delgado, A. V., Prat, M., & Jimenez‐Lopez, C.
Affiliations
  • Departamento de Microbiología Facultad de Ciencias Universidad de Granada Campus Fuentenueva, s/n 18071 Granada Spain
  • Dipartimento di Scienze della Salute Università del Piemonte Orientale A. Avogadro Via Solaroli 17 28100 Novara Italy
  • Departamento de Física Aplicada Facultad de Ciencias Universidad de Granada Campus Fuentenueva, s/n 18071 Granada Spain
ORCID
Jimenez‐Lopez, Concepcion
Venue
Particle & Particle Systems Characterization
Publisher
Wiley
Published
2019-05-13
Volume
36
Issue
6
ISSN
  • 0934-0866
  • 1521-4117
DOI
10.1002/ppsc.201900057
Cited by
29
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • Ministerio de Economía, Industria y Competitividad, Gobierno de España (CGL2013‐46612, CGL2016‐76723)
  • Junta de Andalucía
  • Università degli Studi del Piemonte Orientale

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CoChat. (2026). Citation check: Functionalized Biomimetic Magnetic Nanoparticles as Effective Nanocarriers for Targeted Chemotherapy. https://app.cochat.ai/papers/10.1002/ppsc.201900057
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Peigneux, A., Oltolina, F., Colangelo, D., Iglesias, G. R., Delgado, A. V., Prat, M., & Jimenez‐Lopez, C. (2019). Functionalized Biomimetic Magnetic Nanoparticles as Effective Nanocarriers for Targeted Chemotherapy. Particle & Particle Systems Characterization. https://doi.org/10.1002/ppsc.201900057