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Cited by 1,007

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis

Emerson, Julia, Rosenfeld, Margaret, McNamara, Sharon, Ramsey, Bonnie, Gibson, Ronald L.·2002·Pediatric Pulmonology
DOI 10.1002/ppul.10127
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Abstract

We conducted a registry‐based study to determine prognostic indicators of 8‐year mortality and morbidity in young children with cystic fibrosis (CF). Patients ages 1–5 years from the 1990 U.S. Cystic Fibrosis Foundation (CFF) National Patient Registry served as the study cohort (N = 3,323). Registry data provided information on baseline characteristics in 1990, 8‐year mortality, and clinical outcomes in 1998. P. aeruginosa respiratory infection was found to be a major predictor of morbidity and mortality. The 8‐year risk of death was 2.6 times higher in patients who had respiratory cultures positive for P. aeruginosa in 1990 (95% confidence interval 1.6, 4.1) than in children without P. aeruginosa in their respiratory cultures. Culture‐positive patients in 1990 also had a significantly lower percent predicted forced expiratory volume in 1 sec (FEV 1) and weight percentile at follow‐up, and they had an increased risk of continued P. aeruginosa respiratory infection and hospitalization for acute respiratory exacerbation in 1998. Among the other predictors of increased morbidity and mortality were lower baseline weight percentiles and number of CF‐related hospitalizations during the baseline year. These findings confirm reports from previous smaller studies of outcomes among young children with CF, and highlight the potential to decrease the morbidity and mortality of young patients with CF through early intervention. Pediatr Pulmonol. 2002; 34:91–100. © 2002 Wiley‐Liss, Inc.

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Metadata

Authors
Emerson, J., Rosenfeld, M., McNamara, S., Ramsey, B., & Gibson, R. L.
Venue
Pediatric Pulmonology
Publisher
Wiley
Published
2002-07
Volume
34
Issue
2
Pages
91-100
ISSN
  • 1099-0496 (ISSN-L)
  • 8755-6863
DOI
10.1002/ppul.10127
OpenAlex
W1971558827
Cited by
1,007
References
23
FWCI
12.26
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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