The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis*
Abstract
A thorough understanding of the early natural history of cystic fibrosis (CF) lung disease is critical for the development of effective interventions in the youngest patients. We assessed the evolution of pulmonary infection, inflammation, and clinical course among 40 infants over a 2‐year period through annual bronchoalveolar lavage (BAL) for culture and measurements of pro‐ and anti‐inflammatory cytokines, semiannual infant pulmonary function testing, and quarterly clinical evaluations. Both the prevalence of CF pathogens and their density in BAL fluid increased with age. Infants had neutrophilic lower airway inflammation and elevated IL‐8 concentrations independent of whether CF pathogens were recovered. Total leukocyte and neutrophil densities and IL‐8 concentrations increased with density of CF pathogens in BAL fluid, whether the isolated organism was P. aeruginosa or another pathogen. IL‐10 concentrations were similar in CF subjects and non‐CF historical controls. Infants generally had suboptimal growth (low weight and height percentiles) and obstructive lung disease (decreased expiratory flows and air trapping). Subjects from whom CF pathogens were isolated at > 10 5 cfu/mL had the worst air trapping and lowest Brasfield chest X‐ray scores. Our findings provide a foundation for future studies of early intervention in CF lung disease, including antimicrobial and anti‐inflammatory therapy. Pediatr Pulmonol. 2001; 32:356–366. © 2001 Wiley‐Liss, Inc.
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Cites
The Pathophysiology Of Tumor Necrosis Factors
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Early pulmonary inflammation in infants with cystic fibrosis.
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Inflammatory cytokines in cystic fibrosis lungs.
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Longitudinal Assessment of Pseudomonas aeruginosa in Young Children with Cystic Fibrosis
Burns, J. L., Gibson, R. L., McNamara, S., Yim, D., Emerson, J., Rosenfeld, M., Hiatt, P., McCoy, K., Castile, R., Smith, A. L., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/318075 · Cited by 555
Self-citationDibley, M. J., Goldsby, J. B., Staehling, N. W., & Trowbridge, F. L. (1987) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.5.736 · Cited by 482
Microbiology of Sputum from Patients at Cystic Fibrosis Centers in the United States
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Self-citationQuantitation of Inflammatory Responses to Bacteria in Young Cystic Fibrosis and Control Patients
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Bronchoalveolar Lavage for Diagnosing Acute Bacterial Pneumonia
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Cited by
Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
Gibson, R. L., Burns, J. L., & Ramsey, B. W. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-505so · Cited by 1,633
Self-citationPseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence
Moradali, M. F., Ghods, S., & Rehm, B. H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00039 · Cited by 1,537
Emerson, J., Rosenfeld, M., McNamara, S., Ramsey, B., & Gibson, R. L. (2002) · Pediatric Pulmonology · doi:10.1002/ppul.10127 · Cited by 1,007
Self-citationPseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium
Mesaros, N., Nordmann, P., Plésiat, P., Roussel-Delvallez, M., Van Eldere, J., Glupczynski, Y., Van Laethem, Y., Jacobs, F., Lebecque, P., Malfroot, A., et al. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01681.x · Cited by 585
Airway Surface Dehydration in Cystic Fibrosis: Pathogenesis and Therapy
Boucher, R. C. (2007) · Annual Review of Medicine · doi:10.1146/annurev.med.58.071905.105316 · Cited by 512
Metadata
- Authors
- Rosenfeld, M., Gibson, R. L., McNamara, S., Emerson, J., Burns, J. L., Castile, R., Hiatt, P., McCoy, K., Wilson, C. B., Inglis, A., Smith, A., Martin, T. R., & Ramsey, B. W.
- Venue
- Pediatric Pulmonology
- Publisher
- Wiley
- Published
- 2001-10-09
- Volume
- 32
- Issue
- 5
- Pages
- 356-366
- ISSN
- 1099-0496 (ISSN-L)
- 8755-6863
- OpenAlex
- W2057496127
- Cited by
- 395
- References
- 24
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenfeld, M., Gibson, R. L., McNamara, S., Emerson, J., Burns, J. L., Castile, R., Hiatt, P., McCoy, K., Wilson, C. B., Inglis, A., Smith, A., Martin, T. R., & Ramsey, B. W. (2001). Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis*. Pediatric Pulmonology. https://doi.org/10.1002/ppul.1144
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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