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Detecting early structural lung damage in cystic fibrosis
Abstract
In cystic fibrosis (CF) patients, both severe lung inflammation and severe lung damage occur early and persist throughout life. High‐resolution computed tomography (HRCT), a more sensitive method of detecting structural abnormalities than chest X‐ray, shows that airways undergo substantial thickening in early CF lung disease. Lung function tests, which are an indirect measure of structural integrity, are insensitive to localized or early damage. Thickening of the peripheral airways causes a reduction in maximal expiratory flow at 25% of forced vital capacity (MEF 25) or other measurements of peripheral air flow. Reduced peripheral flows, even in the presence of normal forced expired volume in 1 sec (FEV 1) and forced vital capacity (FVC), should be considered an early sign of substantial lung damage and should stimulate aggressive treatment to prevent further deterioration. Pediatr Pulmonol. 2002; 34:228–231. © 2002 Wiley‐Liss, Inc.
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Cited by
Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
Gibson, R. L., Burns, J. L., & Ramsey, B. W. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-505so · Cited by 1,633
Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis
Gustafsson, P. M., De Jong, P. A., Tiddens, H. A. W. M., & Lindblad, A. (2007) · Thorax · doi:10.1136/thx.2007.077784 · Cited by 364
Self-citationEarly intervention and prevention of lung disease in cystic fibrosis: a European consensus
Döring, G., & Hoiby, N. (2004) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2004.03.008 · Cited by 304
Computed tomographic imaging of the airways: relationship to structure and function
de Jong, P. A., Müller, N. L., Paré, P. D., & Coxson, H. O. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00007105 · Cited by 171
Metadata
- Authors
- Tiddens, H. A. W. M.
- Venue
- Pediatric Pulmonology
- Publisher
- Wiley
- Published
- 2002-08-14
- Volume
- 34
- Issue
- 3
- Pages
- 228-231
- ISSN
- 1099-0496 (ISSN-L)
- 8755-6863
- OpenAlex
- W1986108334
- Cited by
- 177
- References
- 0
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
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