The molecular details of cytokine signaling via the JAK/STAT pathway
Abstract
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation, growth, or apoptosis of their target cells. They act by binding to specific receptors on the surface of target cells and switching on a phosphotyrosine‐based intracellular signaling cascade initiated by kinases then propagated and effected by SH2 domain‐containing transcription factors. As cytokine signaling is proliferative and often inflammatory, it is tightly regulated in terms of both amplitude and duration. Here we review molecular details of the cytokine‐induced signaling cascade and describe the architectures of the proteins involved, including the receptors, kinases, and transcription factors that initiate and propagate signaling and the regulatory proteins that control it.
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STAT3 plays a significant role in controlling the inflammatory response, innate immunity and adaptive immunity.
“The JAK-STAT pathway is a common signaling cascade in which STAT3 plays a significant role in controlling the inflammatory response, innate immunity and adaptive immunity [55, 56].”
From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [55]
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Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works
Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768 · see citing works
The molecular basis of JAK/STAT inhibition by SOCS1
Liau, N. P. D., Laktyushin, A., Lucet, I. S., Murphy, J. M., Yao, S., Whitlock, E., Callaghan, K., Nicola, N. A., Kershaw, N. J., & Babon, J. J. (2018) · Nature Communications · doi:10.1038/s41467-018-04013-1 · Cited by 456 · see citing works
Self-citationSasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Johnston, J. A., & Yoshimura, A. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00263.x · Cited by 398 · see citing works
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12848 · Cited by 388 · see citing works
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
Spangler, J. B., Moraga, I., Mendoza, J. L., & Garcia, K. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120211 · Cited by 304 · see citing works
Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2519 · Cited by 301 · see citing works
Self-citationKotenko, S. V., Izotova, L. S., Mirochnitchenko, O. V., Esterova, E., Dickensheets, H., Donnelly, R. P., & Pestka, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7096 · Cited by 260 · see citing works
A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1
Haspel, R. L., & Darnell, J. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10188 · Cited by 203 · see citing works
Babon, J. J., McManus, E. J., Yao, S., DeSouza, D. P., Mielke, L. A., Sprigg, N. S., Willson, T. A., Hilton, D. J., Nicola, N. A., Baca, M., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.024 · Cited by 163 · see citing works
Self-citationWormald, S., Zhang, J.-G., Krebs, D. L., Mielke, L. A., Silver, J., Alexander, W. S., Speed, T. P., Nicola, N. A., & Hilton, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509595200 · Cited by 123 · see citing works
FAIRLIE, W. D., SOUZA, D. D., NICOLA, N. A., & BACA, M. (2003) · Biochemical Journal · doi:10.1042/bj20030104 · Cited by 20 · see citing works
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- Morris, R., Kershaw, N. J. & Babon, J. J. (2018). The molecular details of cytokine signaling via the JAK/STAT pathway. PROTEIN SCIENCE, 27 (12), pp.1984-2009. https:// doi.org/10.1002/pro.3519. Persistent Link: http://hdl.handle.net/11343/284543
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Rah, B., Rather, R. A., Bhat, G. R., Baba, A. B., Mushtaq, I., Farooq, M., Yousuf, T., Dar, S. B., Parveen, S., Hassan, R., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.821344 · Cited by 202 · see citing works
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- Authors
- Morris, R., Kershaw, N. J., & Babon, J. J.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research 1G Royal Parade, Parkville 3052 Victoria Australia
- ORCID
- Babon, Jeffrey J.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 2018-11-15
- Volume
- 27
- Issue
- 12
- Pages
- 1984-2009
- ISSN
- 0961-8368
- 1469-896X
- Cited by
- 865
- References
- 12
- Language
- en
- Funders
- Department of Health, State Government of Victoria (Operational Infrastructure Grant)
- National Health and Medical Research Council (1113577, 1121755, 1122999, 9000220)
- Cancer Council Victoria (1065180)
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