The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Establishment and characterization of osseous prostate cancer models: Intra‐tibial injection of human prostate cancer cells
Abstract
BACKGROUND: To improve the therapy of advanced prostate cancer (CaP), it is critical to develop animal models that mimic CaP bone metastases. Unlike the human disease, CaP xenograft models rarely metastasize spontaneously to bone from the orthotopic site of primary tumor growth. METHODS: Single‐cell suspensions of LNCaP, PC‐3, LuCaP 35, and LuCaP 23.1 CaP cells were injected directly into tibia of SCID mice. Immunohistochemistry and bone histomorphometrical analyses were performed to characterize these osseous‐CaP models. RESULTS: LuCaP 23.1 yields an osteoblastic response, LNCaP yields mixed lesions, and LuCaP 35 and PC‐3 result in osteolytic responses. We have detected osteoprotegerin, RANK ligand, parathyroid hormone‐related protein, and endothelin‐1, proteins associated with bone growth and remodeling, in the CaP cells grown in the bone. CONCLUSIONS: These animal models can be used to study biological interactions, pathways, and potential therapeutic targets, and also to evaluate new agents for treatment and prevention of CaP bone metastasis. Prostate 52: 20–33, 2002. © 2002 Wiley‐Liss, Inc.
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Cites
Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients
Bubendorf, L., Schöpfer, A., Wagner, U., Sauter, G., Moch, H., Willi, N., Gasser, T. C., & Mihatsch, M. J. (2000) · Human Pathology · doi:10.1053/hp.2000.6698 · Cited by 1,895
Osteoprotegerin and RANK ligand expression in prostate cancer.
Brown, J. M., Corey, E., Lee, Z. D., True, L. D., Yun, T. J., Tondravi, M., & Vessella, R. L. (2001) · Urology · doi:10.1016/s0090-4295(00)01122-5 · Cited by 234
Self-citationItoh, K., Udagawa, N., Matsuzaki, K., Takami, M., Amano, H., Shinki, T., Ueno, Y., Takahashi, N., & Suda, T. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.9.1766 · Cited by 90
Cited by
Sun, S., Sprenger, C. C. T., Vessella, R. L., Haugk, K., Soriano, K., Mostaghel, E. A., Page, S. T., Coleman, I. M., Nguyen, H. M., Sun, H., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41824 · Cited by 748
Self-citationOsteoblasts in prostate cancer metastasis to bone
Logothetis, C. J., & Lin, S.-H. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1528 · Cited by 614
A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases
Yin, J. J., Mohammad, K. S., Käkönen, S. M., Harris, S., Wu-Wong, J. R., Wessale, J. L., Padley, R. J., Garrett, I. R., Chirgwin, J. M., & Guise, T. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1830978100 · Cited by 381
Nguyen, H. M., Vessella, R. L., Morrissey, C., Brown, L. G., Coleman, I. M., Higano, C. S., Mostaghel, E. A., Zhang, X., True, L. D., Lam, H.-M., et al. (2017) · The Prostate · doi:10.1002/pros.23313 · Cited by 300
Self-citationAndrogen receptor is a tumor suppressor and proliferator in prostate cancer
Niu, Y., Altuwaijri, S., Lai, K.-P., Wu, C.-T., Ricke, W. A., Messing, E. M., Yao, J., Yeh, S., & Chang, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804700105 · Cited by 256
Metadata
- Authors
- Corey, E., Quinn, J. E., Bladou, F., Brown, L. G., Roudier, M. P., Brown, J. M., Buhler, K. R., & Vessella, R. L.
- Venue
- The Prostate
- Publisher
- Wiley
- Published
- 2002-05-23
- Volume
- 52
- Issue
- 1
- Pages
- 20-33
- ISSN
- 0270-4137 (ISSN-L)
- 1097-0045
- OpenAlex
- W2146465225
- Cited by
- 192
- References
- 3
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- closed
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