The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Pathobiology of autochthonous prostate cancer in a pre‐clinical transgenic mouse model
Abstract
Background: Animal models that closely mimic clinical disease can be exploited to hasten the pace of translational research. To this end, we have defined windows of opportunity in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model of prostate cancer as a paradigm for designing pre‐clinical trials. Methods: The incidence of cancer, metastasis, and distribution of pathology were examined as a function of time in TRAMP mice. The expression of various markers of differentiation were characterized. Results: The TRAMP model develops progressive, multifocal, and heterogeneous disease. Each lobe of the prostate progressed at a different rate. Cytokeratin 8, E‐cadherin, and androgen receptor (AR) were expressed during cancer progression but levels were reduced or absent in late stage disease. A distinct epithelial to neuroendocrine (ENT) shift was observed to be a stochastic event related to prostate cancer progression in TRAMP. Conclusions: This study will serve as the basis for the rational design of pre‐clinical studies with genetically engineered mouse models. Prostate 55: 219–237, 2003. © 2003 Wiley‐Liss, Inc.
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Self-citationInhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols
Gupta, S., Hastak, K., Ahmad, N., Lewin, J. S., & Mukhtar, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171326098 · Cited by 486
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Self-citationCadherin switching in human prostate cancer progression.
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NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
Guerra, N., Tan, Y. X., Joncker, N. T., Choy, A., Gallardo, F., Xiong, N., Knoblaugh, S., Cado, D., Greenberg, N. R., & Raulet, D. H. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.016 · Cited by 850
Self-citationImmunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy
Shalapour, S., Font-Burgada, J., Di Caro, G., Zhong, Z., Sanchez-Lopez, E., Dhar, D., Willimsky, G., Ammirante, M., Strasner, A., Hansel, D. E., et al. (2015) · Nature · doi:10.1038/nature14395 · Cited by 611
Mouse Models for Cancer Immunotherapy Research
Olson, B., Li, Y., Lin, Y., Liu, E. T., & Patnaik, A. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0044 · Cited by 435
Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.014 · Cited by 371
Mutation of the androgen receptor causes oncogenic transformation of the prostate.
Han, G., Buchanan, G., Ittmann, M., Harris, J. M., Yu, X., DeMayo, F. J., Tilley, W., & Greenberg, N. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408925102 · Cited by 192
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Metadata
- Authors
- Kaplan‐Lefko, P. J., Chen, T., Ittmann, M. M., Barrios, R. J., Ayala, G. E., Huss, W. J., Maddison, L. A., Foster, B. A., & Greenberg, N. M.
- Venue
- The Prostate
- Publisher
- Wiley
- Published
- 2003-04-07
- Volume
- 55
- Issue
- 3
- Pages
- 219-237
- ISSN
- 0270-4137 (ISSN-L)
- 1097-0045
- OpenAlex
- W2084541894
- Cited by
- 438
- References
- 38
- FWCI
- 19.31
- Type
- journal article
- Language
- en
- Open access
- closed
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