The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
PC3 is a cell line characteristic of prostatic small cell carcinoma
Abstract
BACKGROUND: The majority of the prostatic cancers are adenocarcinomas characterized by glandular formation and the expression of luminal differentiation markers androgen receptor (AR) and prostate‐specific antigen (PSA). Most adenocarcinomas are indolent and androgen‐dependent. Hormonal therapy that inhibits AR signaling produces symptomatic relief in patients with advanced and metastatic adenocarcinomas. Prostatic small cell neuroendocrine carcinoma (SCNC) is a variant form of prostate cancer (PC). In contrast to adenocarcinoma, the tumor cells of SCNC do not form glands and are negative for AR and PSA. SCNC is extremely aggressive and does not respond to hormonal therapy. The purpose of this study was to compare the important and relevant features of two most commonly used PC cell lines, LNCaP and PC3, with prostatic adenocarcinoma and SCNC. METHODS: Xenograft tumors of LNCaP and PC3 were prepared and compared with human prostatic adenocarcinoma and SCNC for the expression of key signaling molecules by immunohistochemistry and Western blot analysis. RESULTS: LNCaP cells express AR and PSA and their growth is inhibited by androgen withdrawal, similar to human prostatic adenocarcinoma. PC3 cells do not express AR and PSA and their proliferation is independent of androgen, similar to SCNC. Adenocarcinoma cells and LNCaP cells are negative for neuroendocrine markers and stem cell‐associated marker CD44 while SCNC and PC3 cells are positive. LNCaP cells have identical cytokeratin profiles to adenocarcinoma while PC3 cells have cytokeratin profiles similar to SCNC. CONCLUSION: LNCaP cells share common features with adenocarcinoma while PC3 cells are characteristic of SCNC. Prostate 71:1668–1679, 2011. © 2011 Wiley‐Liss, Inc.
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“In terms of metastatic potential, PC3 cells are thought to be the most aggressive, with LNCaP being relatively more quiescent and DU145 somewhere in between (45, 46).”
From FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins in cells of different lineages (2023) · doi:10.1016/j.jlr.2023.100341 · cites this paper as [45]
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LNCaP model of human prostatic carcinoma.
Horoszewicz, J. S., Leong, S. S., Kawinski, E., Karr, J. P., Rosenthal, H. E., Chu, T. M., MIRAND, E. A., & Murphy, G. P. (1983) · PubMed · Cited by 1,789
Establishment and characterization of a human prostatic carcinoma cell line (PC-3).
Kaighn, M. E., Ks, N., Ohnuki, Y., Lechner, J. F., & Jones, L. W. (1979) · PubMed · Cited by 1,603
Patrawala, L., Calhoun, T., Schneider-Broussard, R., Li, H., Bhatia, B., Tang, S., Reilly, J. G., Chandra, D., Zhou, J., Claypool, K., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209327 · Cited by 968
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A luminal epithelial stem cell that is a cell of origin for prostate cancer
Wang, X., Julio, M. K.-D., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y.-P., Price, S. M., Abate-Shen, C., & Shen, M. M. (2009) · Nature · doi:10.1038/nature08361 · Cited by 734
Molecular characterization of human prostate carcinoma cell lines
van Bokhoven, A., Varella‐Garcia, M., Korch, C., Johannes, W. U., Smith, E. E., Miller, H. L., Nordeen, S. K., Miller, G. J., & Lucia, M. S. (2003) · The Prostate · doi:10.1002/pros.10290 · Cited by 633
Holzbeierlein, J., Lal, P., LaTulippe, E., Smith, A., Satagopan, J., Zhang, L., Ryan, C., Smith, S., Scher, H., Scardino, P., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63112-4 · Cited by 577
Identification of a Cell of Origin for Human Prostate Cancer
Goldstein, A. S., Huang, J., Guo, C., Garraway, I. P., & Witte, O. N. (2010) · Science · doi:10.1126/science.1189992 · Cited by 554
Self-citationThe LNCaP cell line--a new model for studies on human prostatic carcinoma.
Horoszewicz, J. S., Leong, S. S., Chu, T. M., Wajsman, Z., Friedman, M., Papsidero, L. D., Kim, U., Chai, L. S., Kakati, S., Arya, S. K., et al. (1980) · PubMed · Cited by 544
Small Cell Carcinoma of the Prostate: A Morphologic and Immunohistochemical Study of 95 Cases
Wang, W., & Epstein, J. I. (2008) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318058a96b · Cited by 375
Cited by
Fahey, J. M., & Girotti, A. W. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.05.006 · Cited by 77
Lu, T.-L., Han, C.-K., Chang, Y.-S., Lu, T.-J., Huang, H.-C., Bao, B.-Y., Wu, H.-Y., Huang, C.-H., Li, C.-Y., & Wu, T.-S. (2014) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x14500967 · Cited by 37
Okada, T., Uto, K., Aoyagi, T., & Ebara, M. (2016) · Biomaterials Science · doi:10.1039/c5bm00375j · Cited by 20
Hancock, S. E., Ding, E., Johansson Beves, E., Mitchell, T., & Turner, N. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100341 · Cited by 13
Metadata
- Authors
- Tai, S., Sun, Y., Squires, J. M., Zhang, H., Oh, W. K., Liang, C., & Huang, J.
- Venue
- The Prostate
- Publisher
- Wiley
- Published
- 2011-03-22
- Volume
- 71
- Issue
- 15
- Pages
- 1668-1679
- ISSN
- 0270-4137
- 1097-0045
- PMC
- PMC3426349
- Cited by
- 438
- References
- 46
- Language
- en
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