The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Identification of a Cell of Origin for Human Prostate Cancer
Open accessAbstract
Another Cell Culprit in Prostate Cancer: A recent controversial hypothesis about the cellular origins of human cancer, the so-called “cancer stem cell hypothesis,” has fueled interest in identifying the specific cell types that give rise to common epithelial cancers. A single, well-defined cell of origin could, in principle, lead to more effective targeted therapies. Based on histological evidence and/or studies of mouse tumors, luminal cells are believed to be the cell of origin in prostate cancer. Now, using functional assays of cells derived from benign human prostate tissue, Goldstein et al. (p. 568 ) find that a different cell type, basal cells, can give rise in mice to prostate tumors that closely resemble human prostate tumors. Thus, the cellular origin of prostate cancer may be more complex than anticipated.
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Cites
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
Tomlins, S. A., Rhodes, D. R., Perner, S., Dhanasekaran, S. M., Mehra, R., Sun, X.-W., Varambally, S., Cao, X., Tchinda, J., Kuefer, R., et al. (2005) · Science · doi:10.1126/science.1117679 · Cited by 3,846
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Molecular determinants of resistance to antiandrogen therapy
Chen, C. D., Welsbie, D. S., Tran, C., Baek, S. H., Chen, R., Vessella, R., Rosenfeld, M. G., & Sawyers, C. L. (2004) · Nature Medicine · doi:10.1038/nm972 · Cited by 2,278
Zong, Y., Xin, L., Goldstein, A. S., Lawson, D. A., Teitell, M. A., & Witte, O. N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905931106 · Cited by 203
Self-citation
Cited by
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
Plaks, V., Kong, N., & Werb, Z. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.02.015 · Cited by 1,557
Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697
Genomic and biochemical insights into the specificity of ETS transcription factors
Hollenhorst, P. C., McIntosh, L. P., & Graves, B. J. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.79.081507.103945 · Cited by 490
PC3 is a cell line characteristic of prostatic small cell carcinoma
Tai, S., Sun, Y., Squires, J. M., Zhang, H., Oh, W. K., Liang, C., & Huang, J. (2011) · The Prostate · doi:10.1002/pros.21383 · Cited by 438
Self-citationMultipotent and unipotent progenitors contribute to prostate postnatal development
Ousset, M., Van Keymeulen, A., Bouvencourt, G., Sharma, N., Achouri, Y., Simons, B. D., & Blanpain, C. (2012) · Nature Cell Biology · doi:10.1038/ncb2600 · Cited by 221
Metadata
- Authors
- Goldstein, A. S., Huang, J., Guo, C., Garraway, I. P., & Witte, O. N.
- Venue
- Science
- Published
- 2010-07-30
- Volume
- 329
- Issue
- 5991
- Pages
- 568-571
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049700579
- Cited by
- 554
- References
- 4
- FWCI
- 51.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Goldstein, A. S., Huang, J., Guo, C., Garraway, I. P., & Witte, O. N. (2010). Identification of a Cell of Origin for Human Prostate Cancer. Science. https://doi.org/10.1126/science.1189992
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
