The DOI matches its Crossref record.
Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation
Abstract
The effect of the isoflavones, genistein, daidzein, and biochanin A on the growth of the LNCaP and DU‐145 human prostate cancer cell lines has been examined. Genistein and biochanin A, but not daidzein, inhibit both serum and EGF‐stimulated growth of LNCaP and DU‐145 cells (IC50 values from 8.0 to 27 μg/ml for serum and 4.3 to 15 μg/ml for EGF), but have no significant effect of the EGF receptor tyrosine autophosphorylation. In contrast, tyrphostin 25, a specific EGF receptor tyrosine kinase inhibitor, inhibits EGF‐stimulated growth and EGF receptor tyrosine autophosphorylation in these whole cells, but does not inhibit serum‐stimulated growth. These data suggest that the mechanism of action of genistein and biochanin A does not depend on inhibition of EGF receptor tyrosine autophosphorylation, but on a more distal event in the EGF receptor‐mediated signal transduction cascade. © 1993 Wiley‐Liss, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Soy intake and cancer risk: A review of the in vitro and in vivo data
Messina, M. J., Persky, V., Setchell, K. D. R., & Barnes, S. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514310 · Cited by 1,315
Self-citationIsoflavones: estrogenic activity, biological effect and bioavailability
Vitale, D. C., Piazza, C., Melilli, B., Drago, F., & Salomone, S. (2013) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-012-0112-y · Cited by 490
Zava, D. T., & Duwe, G. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514498 · Cited by 462
Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein
Li, Y., Upadhyay, S., Bhuiyan, M., & Sarkar, F. H. (1999) · Oncogene · doi:10.1038/sj.onc.1202650 · Cited by 319
Quantification of genistein and genistin in soybeans and soybean products
Fukutake, M., Takahashi, M., Ishida, K., Kawamura, H., Sugimura, T., & Wakabayashi, K. (1996) · Food and Chemical Toxicology · doi:10.1016/0278-6915(96)87355-8 · Cited by 296
Metadata
- Authors
- Peterson, G., & Barnes, S.
- Venue
- The Prostate
- Publisher
- Wiley
- Published
- 1993-01
- Volume
- 22
- Issue
- 4
- Pages
- 335-345
- ISSN
- 0270-4137 (ISSN-L)
- 1097-0045
- OpenAlex
- W2041679683
- Cited by
- 412
- References
- 0
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. https://app.cochat.ai/papers/10.1002/pros.2990220408
- The paper
- Peterson, G., & Barnes, S. (1993). Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. The Prostate. https://doi.org/10.1002/pros.2990220408
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
