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Protein–protein docking benchmark version 3.0

Open access
Hwang, Howook, Pierce, Brian, Mintseris, Julian, Janin, Joël, Weng, Zhiping·2008·Proteins: Structure, Function, and Bioinformatics

Abstract

We present version 3.0 of our publicly available protein–protein docking benchmark. This update includes 40 new test cases, representing a 48% increase from Benchmark 2.0. For all of the new cases, the crystal structures of both binding partners are available. As with Benchmark 2.0, Structural Classification of Proteins (Murzin et al., J Mol Biol 1995;247:536–540) was used to remove redundant test cases. The 124 unbound‐unbound test cases in Benchmark 3.0 are classified into 88 rigid‐body cases, 19 medium‐difficulty cases, and 17 difficult cases, based on the degree of conformational change at the interface upon complex formation. In addition to providing the community with more test cases for evaluating docking methods, the expansion of Benchmark 3.0 will facilitate the development of new algorithms that require a large number of training examples. Benchmark 3.0 is available to the public at http://zlab.bu.edu/benchmark. Proteins 2008. © 2008 Wiley‐Liss, Inc.

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Metadata

Authors
Hwang, H., Pierce, B., Mintseris, J., Janin, J., & Weng, Z.
Venue
Proteins: Structure, Function, and Bioinformatics
Publisher
Wiley
Published
2008-05-19
Volume
73
Issue
3
Pages
705-709
ISSN
  • 0887-3585 (ISSN-L)
  • 1097-0134
OpenAlex
W2162682281
Cited by
255
References
0
FWCI
10.79
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Protein–protein docking benchmark version 3.0. https://app.cochat.ai/papers/10.1002/prot.22106
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Hwang, H., Pierce, B., Mintseris, J., Janin, J., & Weng, Z. (2008). Protein–protein docking benchmark version 3.0. Proteins: Structure, Function, and Bioinformatics. https://doi.org/10.1002/prot.22106

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