The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Plastics degradation by hydrolytic enzymes: The plastics‐active enzymes database—PAZy
Open accessAbstract
Petroleum‐based plastics are durable and accumulate in all ecological niches. Knowledge on enzymatic degradation is sparse. Today, less than 50 verified plastics‐active enzymes are known. First examples of enzymes acting on the polymers polyethylene terephthalate (PET) and polyurethane (PUR) have been reported together with a detailed biochemical and structural description. Furthermore, very few polyamide (PA) oligomer active enzymes are known. In this article, the current known enzymes acting on the synthetic polymers PET and PUR are briefly summarized, their published activity data were collected and integrated into a comprehensive open access database. The Plastics‐Active Enzymes Database (PAZy) represents an inventory of known and experimentally verified enzymes that act on synthetic fossil fuel‐based polymers. Almost 3000 homologs of PET‐active enzymes were identified by profile hidden Markov models. Over 2000 homologs of PUR‐active enzymes were identified by BLAST. Based on multiple sequence alignments, conservation analysis identified the most conserved amino acids, and sequence motifs for PET‐ and PUR‐active enzymes were derived.
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Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888
Berman, H. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.235 · Cited by 40,196
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
Sievers, F., Wilm, A., Dineen, D., Gibson, T. J., Karplus, K., Li, W., Lopez, R., McWilliam, H., Remmert, M., Söding, J., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.75 · Cited by 15,355
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
Li, W., & Godzik, A. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl158 · Cited by 11,410
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Cd-hit: Accelerated for clustering the next-generation sequencing data
Fu, L., Niu, B., Zhu, Z., Wu, S., & Li, W. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts565 · Cited by 11,175
Exploring Network Structure, Dynamics, and Function Using NetworkX
Hagberg, A. A., Schult, D. A., & Swart, P. J. (2008) · Proceedings of the Python in Science Conference · doi:10.25080/tcwv9851 · Cited by 7,477
T-coffee: a novel method for fast and accurate multiple sequence alignment 1 1Edited by J. Thornton
Notredame, C., Higgins, D. G., & Heringa, J. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4042 · Cited by 6,852
A bacterium that degrades and assimilates poly(ethylene terephthalate)
Yoshida, S., Hiraga, K., Takehana, T., Taniguchi, I., Yamaji, H., Maeda, Y., Toyohara, K., Miyamoto, K., Kimura, Y., & Oda, K. (2016) · Science · doi:10.1126/science.aad6359 · Cited by 3,367
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Rennison, A. P., Fernandez‐Macgregor, J., Melot, J., Durbesson, F., Tandrup, T., Westh, P., Vincentelli, R., & Møller, M. S. (2025) · ChemSusChem · doi:10.1002/cssc.202500468 · Cited by 7
(2026) · doi:10.1128/aem.01698-25
Metadata
- Authors
- Buchholz, P. C. F., Feuerriegel, G., Zhang, H., Perez‐Garcia, P., Nover, L., Chow, J., Streit, W. R., & Pleiss, J.
- Venue
- Proteins: Structure, Function, and Bioinformatics
- Publisher
- Wiley
- Published
- 2022-02-25
- Volume
- 90
- Issue
- 7
- Pages
- 1443-1456
- ISSN
- 0887-3585 (ISSN-L)
- 1097-0134
- OpenAlex
- W4213330195
- Cited by
- 259
- References
- 83
- FWCI
- 19.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Buchholz, P. C. F., Feuerriegel, G., Zhang, H., Perez‐Garcia, P., Nover, L., Chow, J., Streit, W. R., & Pleiss, J. (2022). Plastics degradation by hydrolytic enzymes: The plastics‐active enzymes database—PAZy. Proteins: Structure, Function, and Bioinformatics. https://doi.org/10.1002/prot.26325
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