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Dissolution of different forms of partially porous silicon wafers under simulated physiological conditions
Abstract
Silicon (Si) in the form of orthosilicic acid (Si(OH)4) is vital for normal bone and connective tissue homeostasis. Porous Si films release Si(OH)4 in aqueous solutions in the physiological pH range. This study investigates the release of Si(OH)4 from porous Si films under physiological conditions with the aim of developing a bioavailable form of Si. Using a standardised technique, porous Si films released increasing Si with time. Dissolution was significant at pH 7 and above, and at a temperature of 37 °C. Higher porosity generally promoted dissolution, however multiple layer films did not show enhanced solubility over corresponding single layer controls. These properties will be used to optimise Si nanostructures that slowly deliver orthosilicic acid in the digestive tract.
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Citations
Cited by
Multimodality Imaging Probes: Design and Challenges
Louie, A. (2010) · Chemical Reviews · doi:10.1021/cr9003538 · Cited by 1,044
Porous silicon in drug delivery devices and materials☆
ANGLIN, E., CHENG, L., FREEMAN, W., & SAILOR, M. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.017 · Cited by 889
In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles
Gu, L., Hall, D. J., Qin, Z., Anglin, E., Joo, J., Mooney, D. J., Howell, S. B., & Sailor, M. J. (2013) · Nature Communications · doi:10.1038/ncomms3326 · Cited by 329
Metadata
- Authors
- Anderson, S. H. C., Elliott, H., Wallis, D. J., Canham, L. T., & Powell, J. J.
- Venue
- physica status solidi (a)
- Publisher
- Wiley
- Published
- 2003-05
- Volume
- 197
- Issue
- 2
- Pages
- 331-335
- ISSN
- 0031-8965 (ISSN-L)
- 1521-396X
- OpenAlex
- W2070185729
- Cited by
- 244
- References
- 0
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Anderson, S. H. C., Elliott, H., Wallis, D. J., Canham, L. T., & Powell, J. J. (2003). Dissolution of different forms of partially porous silicon wafers under simulated physiological conditions. physica status solidi (a). https://doi.org/10.1002/pssa.200306519
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