The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles
Open accessAbstract
Fluorescence imaging is one of the most versatile and widely used visualization methods in biomedical research. However, tissue autofluorescence is a major obstacle confounding interpretation of in vivo fluorescence images. The unusually long emission lifetime (5–13 μs) of photoluminescent porous silicon nanoparticles can allow the time-gated imaging of tissues in vivo, completely eliminating shorter-lived (<10 ns) emission signals from organic chromophores or tissue autofluorescence. Here using a conventional animal imaging system not optimized for such long-lived excited states, we demonstrate improvement of signal to background contrast ratio by >50-fold in vitro and by >20-fold in vivo when imaging porous silicon nanoparticles. Time-gated imaging of porous silicon nanoparticles accumulated in a human ovarian cancer xenograft following intravenous injection is demonstrated in a live mouse. The potential for multiplexing of images in the time domain by using separate porous silicon nanoparticles engineered with different excited state lifetimes is discussed. Tissue autofluorescence can lead to considerable noise in fluorescence imaging of biological tissues. Here Gu et al.demonstrate that the use of photoluminescent silicon nanoparticles with long emission lifetimes enable a late time-gated imaging technique where autofluorescence effects are avoided.
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Physics of Semiconductor Devices
(2002) · Kluwer Academic Publishers eBooks · doi:10.1007/b117561 · Cited by 13,963
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
In vivo cancer targeting and imaging with semiconductor quantum dots
Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2004) · Nature Biotechnology · doi:10.1038/nbt994 · Cited by 4,772
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
Nanoparticles in cancer therapy and diagnosis
Brigger, I., Dubernet, C., & Couvreur, P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00044-3 · Cited by 3,039
Drug penetration in solid tumours
Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805
The structural and luminescence properties of porous silicon
Cullis, A. G., Canham, L. T., & Calcott, P. D. J. (1997) · Journal of Applied Physics · doi:10.1063/1.366536 · Cited by 2,512
Fluorescence Lifetime Measurements and Biological Imaging
Berezin, M. Y., & Achilefu, S. (2010) · Chemical Reviews · doi:10.1021/cr900343z · Cited by 2,403
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
Kobayashi, H., Ogawa, M., Alford, R., Choyke, P. L., & Urano, Y. (2010) · Chemical Reviews · doi:10.1021/cr900263j · Cited by 2,200
Biodegradable luminescent porous silicon nanoparticles for in vivo applications
Park, J.-H., Gu, L., von Maltzahn, G., Ruoslahti, E., Bhatia, S. N., & Sailor, M. J. (2009) · Nature Materials · doi:10.1038/nmat2398 · Cited by 1,897
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Metadata
- Authors
- Gu, L., Hall, D. J., Qin, Z., Anglin, E., Joo, J., Mooney, D. J., Howell, S. B., & Sailor, M. J.
- Venue
- Nature Communications
- Published
- 2013-08-12
- Volume
- 4
- Issue
- 1
- Pages
- 2326-2326
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2090745907
- Cited by
- 329
- References
- 33
- FWCI
- 13.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gu, L., Hall, D. J., Qin, Z., Anglin, E., Joo, J., Mooney, D. J., Howell, S. B., & Sailor, M. J. (2013). In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles. Nature Communications. https://doi.org/10.1038/ncomms3326
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