Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum‐graecum Extract and Mineral Formulation
Abstract
The aim of the clinical study was to evaluate the effect of Testofen, a standardized Trigonella foenum-graecum (Fenugreek) extract and mineral formulation, on male libido (sexual drive, urge or desire) in a double blind randomized placebo controlled study. The study recruited 60 healthy males aged between 25 and 52, without erectile dysfunction and randomized to an oral dose (two tablets per day) of the active treatment (600 mg Testofen per day) or placebo for 6 weeks. The primary outcome measure was the DISF-SR (male) self-administered QOL total score and the four domain scores. The secondary outcome was specific quality of life parameters. Testofen had an overall positive effect on physiological aspects of libido. In particular, there was a significant increase in the subdomains of sexual arousal and orgasm. Testofen had a positive effect on QOL in self-reported satisfaction with muscle strength, energy and well-being but did not have an effect on mood or sleep. Serum prolactin and testosterone levels remained within the reference range. It was concluded that Testofen demonstrated a significant positive effect on physiological aspects of libido and may assist to maintain normal healthy testosterone levels.
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The clinical significance of the net benefit of herbal supplements is yet to be determined, with ambiguity regarding long-term safety.
“Therefore, the clinical significance of this net benefit is yet to be determined, with ambiguity regarding long-term safety.[62][63][64][65][66][67][68][69][70][71][72][73]”
From A systematic appraisal of emerging alternative therapies in men’s health and wellness (2025) · cites this paper as [62]
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Yang, P., Niu, Z., Guo, J., Huang, T., Chang, D., & 黄晓朋 (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1903508
- Authors
- Steels, E., Rao, A., & Vitetta, L.
- Affiliations
- Applied Science and Nutrition Pty Ltd, Clinical Trials Brisbane Australia
- The University of Queensland (AU)
- Corresponding author
- Steels, Elizabeth
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2011-02-10
- Volume
- 25
- Issue
- 9
- Pages
- 1294-1300
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2160697406
- Cited by
- 71
- References
- 31
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- fenugreek extract, fenugreek, male libido, sexual function, quality of life, sexual arousal, orgasm, testosterone, prolactin, healthy men
- MeSH terms
- Adult, Double-Blind Method, Humans, Libido, Magnesium, Male, Middle Aged, Plant Extracts, Prolactin, Pyridoxine, Quality of Life, Testosterone, Zinc, Patient Satisfaction, Trigonella
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