Puerarin: A Review of Pharmacological Effects

Vasoregulation by the β1 subunit of the calcium-activated potassium channel

Brenner, R., Peréz, G. J., Bonev, A. D., Eckman, D. M., Kosek, J. C., Wiler, S. W., Patterson, A. J., Nelson, M. T., & Aldrich, R. W. (2000) · Nature · doi:10.1038/35038011 · Cited by 796

Soy Isoflavones and Cancer Prevention: CLINICAL SCIENCE REVIEW

Sarkar, F. H., & Li, Y. (2003) · Cancer Investigation · doi:10.1081/cnv-120023773 · Cited by 383

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

Wong, K. H., Li, G. Q., Li, K. M., Razmovski-Naumovski, V., & Chan, K. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.02.001 · Cited by 373

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

Xie, W., & Du, L. (2011) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01336.x · Cited by 304

Antihyperglycemic Effect of Puerarin in Streptozotocin-Induced Diabetic Rats

Hsu, F.-L., Liu, I.-M., Kuo, D.-H., Chen, W.-C., Su, H.-C., & Cheng, J.-T. (2003) · Journal of Natural Products · doi:10.1021/np0203887 · Cited by 221

Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies

Park, O. J., & Surh, Y.-J. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.06.001 · Cited by 203

Profiling and Quantification of Isoflavonoids in Kudzu Dietary Supplements by High-Performance Liquid Chromatography and Electrospray Ionization Tandem Mass Spectrometry

Prasain, J. K., Jones, K., Kirk, M., Wilson, L., Smith-Johnson, M., Weaver, C., & Barnes, S. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030174a · Cited by 182

Puerarin protects rat pancreatic islets from damage by hydrogen peroxide

Fu-Liang, X., Sun, X., Lu, G., Yang, X., & Xu, H. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.024 · Cited by 152

Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

Liu, C., Ma, J., & Sun, Y.-Z. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.11.015 · Cited by 151

Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity

Imanishi, T., Hano, T., & Nishio, I. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000176788.12376.20 · Cited by 142

Induction of apoptosis by puerarin in colon cancer HT-29 cells

Yu, Z., & Li, W. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.06.022 · Cited by 133

Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats

Chang, Y., Hsieh, C., Peng, Z.-A., Yen, T., Hsiao, G., Chou, D., Chen, C., & Sheu, J. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-9 · Cited by 130

Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice

Chung, M. J., Sung, N., Park, C., Kweon, D.-K., Mantovani, A., Moon, T.-W., Lee, S., & Park, K. H. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.036 · Cited by 123

Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats

Liu, C., Ma, J., & Sun, Y.-Z. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.09.007 · Cited by 122

Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery

Yeung, D. K. Y., Leung, S. W. S., Xu, Y. C., Vanhoutte, P. M., & Man, R. Y. K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.078 · Cited by 118

Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead

Liu, C., Ma, J., & Sun, Y.-Z. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.11.016 · Cited by 114

Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death

Zhu, G., Wang, X., Wu, S.-B., & Li, Q. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.01.003 · Cited by 111

Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function

Li, R., Xu, L., Liang, T., Li, Y., Zhang, S., & Duan, X. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.059 · Cited by 111

Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway

Zou, Y. S., Hong, B., Fan, L., Zhou, L., Liu, Y., Wu, Q., Zhang, X., & Dong, M. (2012) · Free Radical Research · doi:10.3109/10715762.2012.742518 · Cited by 107

Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress

Kim, J., Kim, K. M., Kim, C., Sohn, E., Lee, Y. M., Jo, K., & Kim, J. S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.030 · Cited by 97

Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells

Lin, Y., Hou, Y., Lin, C., Hsu, Y.-A., Sheu, J. J., Lai, C., Chen, B., Chao, P.-D. L., Wan, L., & Tsai, F. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.178 · Cited by 97

Plant derivatives in the treatment of alcohol dependency

Rezvani, A. H., Overstreet, D. H., Perfumi, M. C., & Massi, M. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00124-2 · Cited by 95

Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway

Xing, G., Dong, M., Li, X., Zou, Y. S., Fan, L., Wang, X., Cai, D., Li, C., Li, Z., Liu, J., et al. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.03.024 · Cited by 94

Ischemic conditioning by short periods of reperfusion attenuates renal ischemia/reperfusion induced apoptosis and autophagy in the rat

Wu, H.-H., Hsiao, T., Chien, C., & Lai, M.-K. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-19 · Cited by 92

Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin

Gao, Q. F., Yang, B., Ye, Z., Wang, J., Bruce, I. C., & Xia, Q. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.07.018 · Cited by 90

Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways

Zhang, H., Liu, Y., Lao, M., Ma, Z., & Yi, X. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.013 · Cited by 86

Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo

Li, J., Wang, G., Liu, J., Li, Z., Dong, M., Wang, R., Li, X., Li, X., Lin, C., & Niu, Y. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.045 · Cited by 86

Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCβ2/Rac1-dependent signaling

Zhu, L.-H., Wang, L., Wang, D., Jiang, H., Tang, Q., Yan, L., Bian, Z., Wang, X.-A., & Li, H. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.040 · Cited by 85

Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway

Guo, C., Xu, L., He, Q., Liang, T., Duan, X., & Li, R. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.02.051 · Cited by 85

Neuroprotective Effects of Puerarin on 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine induced Parkinson's Disease Model in Mice

Zhu, G., Wang, X., Wu, S.-B., Li, X., & Li, Q. (2013) · Phytotherapy Research · doi:10.1002/ptr.4975 · Cited by 84

Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP+-elicited apoptosis

Cheng, Y.-F., Zhu, G., Wang, M., Cheng, H. D., Zhou, A., Wang, N., Fang, N., Wang, X., Xiao, X., Chen, Z., et al. (2008) · Neuroscience Research · doi:10.1016/j.neures.2008.10.009 · Cited by 84

Preventive Effects of Puerarin on Alcohol-induced Osteonecrosis

Wang, Y., Li, Y., Li, Y., Liu, P., & Cui, Q. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0178-7 · Cited by 82

Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin

Zhang, S., Ji, G., & Liu, J. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.09.002 · Cited by 82

Puerarin protects PC12 cells against β‐amyloid‐induced cell injury

Zhang, H., Liu, Y., Wang, H., Xu, J., & Hu, H. (2008) · Cell Biology International · doi:10.1016/j.cellbi.2008.07.006 · Cited by 81

Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells

Hu, W., Yang, X., Cao, Z., Zhang, Q., Sun, L., & Cao, K. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70590-4 · Cited by 76

The Chinese Pueraria root extract (Pueraria lobota) ameliorates impaired glucose and lipid metabolism in obese mice

Prasain, J., Ning, P., Rajbhandari, R., & Wyss, J. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.09.017 · Cited by 74

Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet

Zhang, W., Liu, C., Wang, P., Sun, S.-Y., Su, W., Zhang, H., Li, X., & Yang, S. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.054 · Cited by 72

Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression

Chen, R., Xue, J., & Xie, M.-L. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.05.015 · Cited by 71

Puerarinprotects against ischemic brain injury in a rat model of transient focal ischemia

Gao, L. Q., Ji, X., Song, J., Liu, P., Yan, F., Gong, W., Dang, S., & Luo, Y. (2009) · Neurological Research · doi:10.1179/174313209x444017 · Cited by 70

Therapeutic Effect of Puerarin on Non-Alcoholic Rat Fatty Liver by Improving Leptin Signal Transduction through JAK2/STAT3 Pathways

Zheng, P., Ji, G., Ma, Z., Liu, T., Xin, L., Wu, H., Liang, X., & Liu, J. (2009) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x09006692 · Cited by 69

P2X receptors and modulation of pain transmission: Focus on effects of drugs and compounds used in traditional Chinese medicine

Liang, S., Xu, C., Li, G., & Gao, Y. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.09.004 · Cited by 66

Puerarin Protects Dopaminergic Neurons against 6-Hydroxydopamine Neurotoxicity via Inhibiting Apoptosis and Upregulating Glial Cell Line-Derived Neurotrophic Factor in a Rat Model of Parkinson's Disease

Zhu, G., Wang, X., Chen, Y., Yang, S., Cheng, Y.-F., Wang, N., & Li, Q. (2010) · Planta Medica · doi:10.1055/s-0030-1249976 · Cited by 64

Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase

Hwang, Y. P., Kim, H. G., Hiền, T. T., Jeong, M. H., Jeong, T. C., & Jeong, H. G. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.08.017 · Cited by 64

Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: A possible pathway through the induction of heme oxygenase-1 expression

Kim, K. M., Jung, D. H., Jang, D. S., Kim, Y. S., Kim, J. M., Kim, H., Surh, Y., & Kim, J. S. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.12.023 · Cited by 61

Puerarin Inhibits C‐Reactive Protein Expression via Suppression of Nuclear Factor κB Activation in Lipopolysaccharide‐Induced Peripheral Blood Mononuclear Cells of Patients with Stable Angina Pectoris

Yang, X., Hu, W., Zhang, Q., Wang, Y., & Sun, L. (2010) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2010.00548.x · Cited by 60

Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons

Xu, C., Xu, W., Xu, H., Xiong, W., Gao, Y., Li, G., Liu, S., Xie, J., Tu, G., Peng, H., et al. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.007 · Cited by 60

Puerarin Suppresses Invasion and Vascularization of Endometriosis Tissue Stimulated by 17β-Estradiol

Wang, D., Liu, Y., Han, J., Zai, D., Ji, M., Cheng, W., Xu, L., Yang, L., He, M., Ni, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025011 · Cited by 60

Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner

Huang, F., Liu, K., Du, H., Kou, J., & Liu, B. (2012) · Biochimie · doi:10.1016/j.biochi.2012.01.018 · Cited by 59

Puerarin Ameliorates Experimental Alcoholic Liver Injury by Inhibition of Endotoxin Gut Leakage, Kupffer Cell Activation, and Endotoxin Receptors Expression

Peng, J., Cui, T., Huang, F., Chen, L., Zhao, Y., Xu, L., Xu, L., Feng, Q., & Hu, Y. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201137 · Cited by 59

Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase

Liu, C., Zheng, G., Ming, Q.-L., et al. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.02.009 · Cited by 58

Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica

Tiyasatkulkovit, W., Charoenphandhu, N., Wongdee, K., Thongbunchoo, J., Krishnamra, N., & Malaivijitnond, S. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.07.010 · Cited by 57

Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase

Noh, B.-K., Lee, J. K., Jun, H., Lee, J. H., Jia, Y., Hoang, M.-H., Kim, J. W., Park, K. H., & Lee, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.09.077 · Cited by 57

Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages

Yao, X.-J., Yin, J.-A., Xia, Y., Wei, Z., Luo, Y., Liu, M., Feleder, C., & Dai, Y. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.02.038 · Cited by 51

Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3‐L1 cells

Lee, O., Seo, D., Park, C., & Kim, Y. (2010) · BioFactors · doi:10.1002/biof.119 · Cited by 51

Puerarin Exerted Anti-Osteoporotic Action Independent of Estrogen Receptor-Mediated Pathway

Michihara, S., Tanaka, T., Uzawa, Y., Moriyama, T., & Kawamura, Y. (2012) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.58.202 · Cited by 50

Puerarin protects against high glucose-induced acute vascular dysfunction: Role of heme oxygenase-1 in rat thoracic aorta

Meng, X., Ni, C., Zhu, L., Shen, Y., Wang, L., & Chen, Y. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.11.003 · Cited by 47

Endometriotic Implants Regress in Rat Models Treated With Puerarin by Decreasing Estradiol Level

Chen, Y., Chen, C., Shi, S., Han, J., Wang, J., Hu, J., Liu, Y., Cai, Z., & Yu, C. (2011) · Reproductive Sciences · doi:10.1177/1933719111398500 · Cited by 47

Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells

Wang, G., Li, Z., Zhang, Y., Dong, M., Li, X., Liu, J., & Niu, Y. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.002 · Cited by 46

Puerarin protects differentiated PC12 cells from H2O2‐induced apoptosis through the PI3K/Akt signalling pathway

Zhang, Q., Huang, W., Lv, X., & Yang, Y. (2011) · Cell Biology International · doi:10.1042/cbi20100900 · Cited by 45

Puerarin Suppresses Proliferation of Endometriotic Stromal Cells Partly via the MAPK Signaling Pathway Induced by 17ß-estradiol-BSA

Cheng, W., Chen, L., Yang, S., Han, J., Zhai, D., Ni, J., Yu, C., & Cai, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045529 · Cited by 43

Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery

Deng, Y. P., Ng, E. S.-K., Yeung, J. H. K., Kwan, Y. W., Lau, C. B., Koon, J. C. M., Zhou, L., Zuo, Z., Leung, P., Fung, K., et al. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.11.021 · Cited by 43

Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart

Gao, Q. F., Pan, H., Qiu, S., Lü, Y., Bruce, I. C., Luo, J., & Xia, Q. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.12.040 · Cited by 43

Puerarin Inhibits Adhesion Molecule Expression in TNF-α-Stimulated Human Endothelial Cells via Modulation of the Nuclear Factor ĸB Pathway

Hu, W., Zhang, Q., Yang, X., et al. (2009) · Pharmacology · doi:10.1159/000264938 · Cited by 41

Puerarin exhibits weak estrogenic activity in female rats

Malaivijitnond, S., Tungmunnithum, D., Gittarasanee, S., Kawin, K., & Limjunyawong, N. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.01.019 · Cited by 41

Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ–induced early diabetic rats

Chen, F., Zhang, H., Zhu, J., Liu, K., Cheng, H. S., Li, G., Xu, S., Lv, W., & Xie, Z. (2012) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(12)60166-7 · Cited by 38

Puerarin Induces Mitochondria-Dependent Apoptosis in Hypoxic Human Pulmonary Arterial Smooth Muscle Cells

Chen, C., Chen, C., Wang, Z., Wang, L., Yang, L., Minjiao, D., Ding, C., Sun, Y., Lin, Q. D., Huang, X., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034181 · Cited by 37

Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats

Rachoń, D., Vortherms, T., Seidlová‐Wuttke, D., & Wuttke, W. (2007) · Maturitas · doi:10.1016/j.maturitas.2006.12.003 · Cited by 36

Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats

Wang, L., Lin, S., Li, Z., Yang, D.-B., & Wang, Z. (2012) · Human & Experimental Toxicology · doi:10.1177/0960327112462729 · Cited by 35

Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways

Wang, P., Zhu, X., Yang, L., Liang, H., Feng, S.-W., & Zhang, R. (2012) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2012.702757 · Cited by 34

Phytoestrogens induce differential estrogen receptor β-mediated responses in transfected MG-63 cells

Tang, X., Zhu, X., Liu, S., Nicholson, R. C., & Ni, X. (2008) · Endocrine · doi:10.1007/s12020-008-9099-1 · Cited by 33

Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats

Shen, J. G., Yao, M., Chen, X. C., Feng, Y. F., Ye, Y. H., & Tong, Z. H. (2009) · Molecular Biology Reports · doi:10.1007/s11033-008-9438-6 · Cited by 31

Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity

Zhu, J., Wang, X., Shang, Y., Xie, X., Zhang, F., Chen, J.-Z., & Fu, G. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.07.002 · Cited by 29

Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X7 receptors

Zhang, J., Li, X., Gao, Y., Guo, G., Xu, C., Li, G., Liu, S., Huang, A., Tu, G., Peng, H., et al. (2012) · Burns · doi:10.1016/j.burns.2012.08.013 · Cited by 29

Dynamic Oxidative Stress and DNA Damage Induced by Oestrogen Deficiency and Protective Effects of P uerarin and 17β‐ O estradiol in Ovariectomized Rats

Tang, X., Liu, X., Tian, Q., & Zhang, W. (2012) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2012.00864.x · Cited by 27

Nitrite–glucose–glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: Effects of some flavonoids

Lu, N., Zhang, Y., & Gao, Z. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.02.013 · Cited by 23

Effect of puerarin on retinal pigment epithelial cells apoptosis induced partly by peroxynitrite via Fas/FasL pathway.

Hao, L.-N., Zhang, Y., Shen, Y., Wang, Z., Wang, Y.-H., Zhang, H.-F., & He, S.-Z. (2010) · PubMed Central · doi:10.3980/j.issn.2222-3959.2010.04.01 · Cited by 22

Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes

Choi, Y.-M., Jun, H., Dawson, K., Rodriguez, R. L., Roh, M. R., Jun, J., Choi, C., Shim, J., Lee, C.-H., Lee, S. J., et al. (2010) · European Food Research and Technology · doi:10.1007/s00217-010-1251-5 · Cited by 17

Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity

Yu, C., Li, Y., Chen, H., Yang, S., & Xie, G. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.09.045 · Cited by 16

The Study to Reduce the Hemolysis Side Effect of Puerarin by a Submicron Emulsion Delivery System

Yue, P., Yuan, H.-L., Zhu, W., Cong, L., Xie, H., Liu, Z., Wang, L., & Xiao, X. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.45 · Cited by 16

Puerarin protects human umbilical vein endothelial cells against high glucose‐induced apoptosis by upregulating heme oxygenase‐1 and inhibiting calpain activation

Chen, Y., Chen, J., Zhou, X., Meng, X., Jiang, J., & Shen, Y. (2011) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2011.00926.x · Cited by 16

Regulatory mechanism of malignant behavior of endometriosis mediated by puerarin

Yu, C. (2009) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20090106 · Cited by 13

[Inhibitory effect of flavonoids of puerarin on proliferation of different human acute myeloid leukemia cell lines in vitro].

Shao, H.-M., Yu-hong, T., Jiang, P., et al. (2010) · PubMed · Cited by 8

Effects of puerarin on expressions of leptin receptor mRNA, phosphoryla-ted Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver

Zheng, P. (2008) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20080909 · Cited by 6

Regulation of aromatase P450 expression by puerarin in endometrial cell line RL95-2

Li, Y. (2008) · Journal of Chinese Integrative Medicine · doi:10.3736/jcim20081006 · Cited by 5

Targeting ferroptosis opens new avenues for the development of novel therapeutics

Sun, S., Shen, J., Jiang, J., Wang, F., & Min, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01606-1 · Cited by 608

Staphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments

Ahmad-Mansour, N., Loubet, P., Pouget, C., Dunyach-Remy, C., Sotto, A., Lavigne, J.-P., & Molle, V. (2021) · Toxins · doi:10.3390/toxins13100677 · Cited by 386

Role of p38/MAPKs in Alzheimer's Disease: Implications for Amyloid Beta Toxicity Targeted Therapy

Kheiri, G., Dolatshahi, M., Rahmani, F., & Rezaei, N. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0008 · Cited by 211

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

Zeng, J., Bao, T., Yang, K., Zhu, X., Wang, S., Xiang, W., Ge, A., Zeng, L., & Ge, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1047550 · Cited by 175