The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The Measurement of Partition Coefficients
Abstract
Partition coefficient (P) is a widely‐measured property, yet there is considerable variation among published log P values. This paper examines the factors that can affect the measurement of partition coefficient, and makes recommendations as to good practice. Accuracy of partition coefficient determination can be affected by temperature, lack of mutual phase saturation, pH, buffer type and concentration, phase miscibility, solute concentration, solute and solvent purity, solute stability, phase volume ratio, solute adsorption and failure to reach equilibrium conditions. It is recommended that partitioning be carried out at constant temperature using either a stirred flask technique or the filter probe.
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Cites
Partition coefficients and their uses
Leo, A., Hansch, C., & Elkins, D. (1971) · Chemical Reviews · doi:10.1021/cr60274a001 · Cited by 4,540
HANSCH, C., MALONEY, P. P., FUJITA, T., & MUIR, R. M. (1962) · Nature · doi:10.1038/194178b0 · Cited by 1,056
Meyer, H. (1899) · Archiv für Experimentelle Pathologie und Pharmakologie · doi:10.1007/bf01834479 · Cited by 1,014
Octanol-water partition coefficients of polychlorinated biphenyl congeners
Hawker, D. W., & Connell, D. W. (1988) · Environmental Science & Technology · doi:10.1021/es00169a004 · Cited by 846
Chromatographic hydrophobic parameters in correlation analysis of structure-activity relationships
Tomlinson, E. (1975) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)88797-x · Cited by 197
Solubility and Partitioning VI: Octanol Solubility and Octanol–Water Partition Coefficients
Yalkowskyx, S. H., Valvani, S. C., & Roseman, T. J. (1983) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600720808 · Cited by 190
Miller, M. M., Ghodbane, S., Wasik, S. P., Tewari, Y. B., & Martire, D. E. (1984) · Journal of Chemical & Engineering Data · doi:10.1021/je00036a027 · Cited by 173
Partition coefficient : determination and estimation
Dunn, W. J., Block, J. H., Pearlman, R. S., & Section, C. (1986) · Cited by 145
Hansch, C. H., & Klein, T. E. (1986) · Accounts of Chemical Research · doi:10.1021/ar00132a003 · Cited by 141
Strategy of Drug Design: A Molecular Guide to Biological Activity
Cheng, C. (1975) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600640438 · Cited by 33
Cited by
Physicochemical Profiling (Solubility, Permeability and Charge State)
Avdeef, A. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013395100 · Cited by 587
General Principles and Strategies for Salting-Out Informed by the Hofmeister Series
Hyde, A. M., Zultanski, S. L., Waldman, J. H., Zhong, Y.-L., Shevlin, M., & Peng, F. (2017) · Organic Process Research & Development · doi:10.1021/acs.oprd.7b00197 · Cited by 526
Braekevelt, E., Tittlemier, S. A., & Tomy, G. T. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00841-x · Cited by 340
The Characterization of Chemical Structures Using Molecular Properties. A Survey
Livingstone, D. J. (2000) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci990162i · Cited by 252
Abraham, M. H., Gil-Lostes, J., Corr, S., & Acree, W. E. (2012) · Journal of Chromatography A · doi:10.1016/j.chroma.2012.09.085 · Cited by 3
Metadata
- Authors
- Dearden, J. C., & Bresnen, G. M.
- Venue
- Quantitative Structure-Activity Relationships
- Publisher
- Wiley
- Published
- 1988-01
- Volume
- 7
- Issue
- 3
- Pages
- 133-144
- ISSN
- 0931-8771 (ISSN-L)
- 1521-3838
- OpenAlex
- W2036882287
- Cited by
- 270
- References
- 10
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- closed
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