The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
UPLC/MS E ; a new approach for generating molecular fragment information for biomarker structure elucidation
Open accessAbstract
A new approach to obtain fragmentation information in liquid chromatography/mass spectrometry (LC/MS) studies of small molecules in complex mixtures is presented using simultaneous acquisition of exact mass at high and low collision energy, MS E . LC/MS‐TOF and LC/MS/MS‐TOF are powerful tools for the analysis of complex mixtures, especially those for biological fluids allowing the elucidation of elemental composition and fragmentation information. In this example the composition of rat urine was studied using this new approach, allowing the structures of several endogenous components to be confirmed in one analytical run by the simultaneous acquisition of exact mass precursor and fragment ion data. The spectral data obtained using this new approach are comparable to those obtained by conventional LC/MS/MS as exemplified by the identification of endogenous metabolites present in rat urine. Copyright © 2006 John Wiley & Sons, Ltd.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nicholson, J. K., Lindon, J. C., & Holmes, E. (1999) · Xenobiotica · doi:10.1080/004982599238047 · Cited by 3,895
Self-citationBrindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W. L., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., et al. (2002) · Nature Medicine · doi:10.1038/nm1202-802 · Cited by 1,029
Self-citationQuantitative Metabolome Analysis Using Capillary Electrophoresis Mass Spectrometry
Soga, T., Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., & Nishioka, T. (2003) · Journal of Proteome Research · doi:10.1021/pr034020m · Cited by 973
Fiehn, O., Kopka, J., Trethewey, R. N., & Willmitzer, L. (2000) · Analytical Chemistry · doi:10.1021/ac991142i · Cited by 591
HPLC-MS-based methods for the study of metabonomics
WILSON, I., PLUMB, R., GRANGER, J., MAJOR, H., WILLIAMS, R., & LENZ, E. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2004.07.045 · Cited by 447
Self-citationWilson, I. D., Nicholson, J. K., Castro-Perez, J., Granger, J. H., Johnson, K. A., Smith, B. W., & Plumb, R. S. (2005) · Journal of Proteome Research · doi:10.1021/pr049769r · Cited by 420
Self-citationGavaghan, C. L., Holmes, E., Lenz, E., Wilson, I. D., & Nicholson, J. K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02147-5 · Cited by 321
Self-citationA 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects
Lenz, E. M., Bright, J., Wilson, I. D., Morgan, S. R., & Nash, A. F. P. (2003) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(03)00410-2 · Cited by 241
Self-citationPlumb, R. S., Granger, J. H., Stumpf, C. L., Johnson, K. A., Smith, B. W., Gaulitz, S., Wilson, I. D., & Castro-Perez, J. (2005) · The Analyst · doi:10.1039/b501767j · Cited by 218
Self-citationWrona, M. D., Mauriala, T., Bateman, K. P., et al. (2005) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2101 · Cited by 177
Cited by
Gillet, L. C., Navarro, P., Tate, S., Röst, H., Selevsek, N., Reiter, L., Bonner, R., & Aebersold, R. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.o111.016717 · Cited by 2,877
Untargeted Metabolomics Strategies—Challenges and Emerging Directions
Schrimpe-Rutledge, A. C., Codreanu, S. G., Sherrod, S. D., & McLean, J. A. (2016) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-016-1469-y · Cited by 1,372
Bruderer, R., Bernhardt, O. M., Gandhi, T., Miladinović, S. M., Cheng, L.-Y., Messner, S., Ehrenberger, T., Zanotelli, V., Butscheid, Y., Escher, C., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.044305 · Cited by 1,238
Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present
Bantscheff, M., Lemeer, S., Savitski, M. M., & Kuster, B. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6203-4 · Cited by 801
A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria
Light, S. H., Su, L., Rivera-Lugo, R., Cornejo, J. A., Louie, A., Iavarone, A. T., Ajo-Franklin, C. M., & Portnoy, D. A. (2018) · Nature · doi:10.1038/s41586-018-0498-z · Cited by 632
Metadata
- Authors
- Plumb, R. S., Johnson, K. A., Rainville, P., Smith, B. W., Wilson, I. D., Castro‐Perez, J. M., & Nicholson, J. K.
- Venue
- Rapid Communications in Mass Spectrometry
- Publisher
- Wiley
- Published
- 2006-06-06
- Volume
- 20
- Issue
- 13
- Pages
- 1989-1994
- ISSN
- 0951-4198 (ISSN-L)
- 1097-0231
- OpenAlex
- W1993652628
- Cited by
- 485
- References
- 19
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: UPLC/MS E ; a new approach for generating molecular fragment information for biomarker structure elucidation. https://app.cochat.ai/papers/10.1002/rcm.2550
- The paper
- Plumb, R. S., Johnson, K. A., Rainville, P., Smith, B. W., Wilson, I. D., Castro‐Perez, J. M., & Nicholson, J. K. (2006). UPLC/MS E ; a new approach for generating molecular fragment information for biomarker structure elucidation. Rapid Communications in Mass Spectrometry. https://doi.org/10.1002/rcm.2550
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
