Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry
Abstract
A method for the determination of several household biocides in water by liquid chromatography/electrospray ionisation tandem mass spectrometry (LC/ESI-MS/MS) is presented. It permits the simultaneous determination of triclosan (TCS), triclocarban (TCC) and seven parabens, including the distinction between branched and linear isomers of propyl (i-PrP and n-PrP) and butyl parabens (i-BuP and n-BuP). Prior to LC/MS/MS, analytes are preconcentrated by solid-phase extraction (SPE) on Oasis HLB (60 mg) cartridges at natural sample pH and subsequently eluted with 4 mL of methanol. This simple SPE procedure provides extraction recoveries above 85% except for raw wastewater, where it falls to 65% for TCC. The performance of the method was tested with two triple-quadrupole LC/MS instruments from a low/mid and mid/high market range: a Varian 1200L and an API-4000. The latter system provided between 3 and 80 times lower limits of quantification (LOQs) than the first one, in the 0.08-0.44 ng/L range for surface water. Moreover, a comparison of matrix effects on both instruments showed a very different behaviour, particularly in the case of parabens. For these compounds signal suppression was observed in the 1200L instrument and signal enhancement with the 4000 instrument. As a result, different calibration approaches were chosen for them and this pointed to the need of matrix effect re-evaluation in method transfer between different LC/MS systems. The application of the method to real sa…
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Recoveries are comparable with those obtained using conventional SPE/LC-MS.
“Recoveries are comparable with those obtained using conventional SPE/LC-MS [55].”
From Automated dispersive liquid-liquid microextraction based on the solidification of the organic phase (2018) · cites this paper as [55]
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- Authors
- González‐Mariño, I., Quintana, J. B., Rodríguez, I., & Cela, R.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Corresponding author
- Quintana, José Benito
- Venue
- Rapid Communications in Mass Spectrometry
- Publisher
- Wiley
- Published
- 2009-05-12
- Volume
- 23
- Issue
- 12
- Pages
- 1756-1766
- ISSN
- 0951-4198 (ISSN-L)
- 1097-0231
- OpenAlex
- W2149987399
- Cited by
- 160
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 15 · 2018: 21 · 2017: 11 · 2016: 14 · 2015: 10 · 2014: 20 · 2013: 5 · 2012: 6
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Rapid Communications in Mass Spectrometry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Spanish Ministry of Science and Innovation (CTQ2006-03334)
- FEDER
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- parabens, triclosan, triclocarban, water pollution, solid-phase extraction, matrix effects, isomer identification, propylparaben, butylparaben, methylparaben, raw sewage, surface water, method transfer
- MeSH terms
- Carbanilides, Chromatography, Liquid, Parabens, Triclosan, Water Pollutants, Chemical, Spectrometry, Mass, Electrospray Ionization, Tandem Mass Spectrometry
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