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Cited by 407Reproductive System and PregnancyPregnancy and preeclampsia studiesReproductive Biology and Fertility

Decidualization of the human endometrium

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Okada, Hidetaka, Tsuzuki, Tomoko, Murata, Hiromi·2018·Reproductive Medicine and Biology
DOI 10.1002/rmb2.12088PMC PMC6046526
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Abstract

Background: Decidualization of the human endometrium, which involves a dramatic morphological and functional differentiation of human endometrial stromal cells (ESC s), is essential for the establishment of a successful pregnancy. Decidualization results from a complex interplay of transcription factors, morphogens, cytokines, cell cycle regulators, and signaling pathways. Methods: Based on a literature review, the regulation of, and the molecular mechanisms involved in, the decidualization of the endometrium are described. Main findings: Progesterone, together with proteins that are regulated by progesterone and/or cyclic adenosine monophosphate, including homeobox A10, forkhead box O1, signal transducers and activators of transcription, and heart and neural crest derivatives expressed transcript 2, forms a critical network for ESC decidualization and is a prerequisite to successful implantation. Decidualized ESC s contribute to the microenvironment at the feto–maternal interface and its direct or indirect influence on extracellular matrix remodeling, regulation of the local immune response, anti‐oxidative stress, and angiogenesis (vascular maturation). Impairment of this process is associated with a variety of pregnancy disorders, including infertility, recurrent miscarriages, and uteroplacental disorders. Conclusion: A deeper understanding of the process of decidualization is expected to provide new insights into the fields of reproductive biology and reproductive medicine.

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  • Decidualization is dysregulated in both endometriosis and PCOS.

    “Decidualization, the collective biochemical and morphological changes to the endometrium that prepare it for implantation (Okada et al., 2018), is dysregulated in both endometriosis and PCOS.”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Okada et al., 2018

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Authors
Okada, H., Tsuzuki, T., & Murata, H.
Affiliations
  • Kansai Medical University (JP)
  • Department of Obstetrics and Gynecology Kansai Medical University Osaka Japan
Corresponding author
Okada, Hidetaka
ORCID
Venue
Reproductive Medicine and Biology
Publisher
Wiley
Published
2018-02
Volume
17
Issue
3
Pages
220-227
ISSN
  • 1445-5781 (ISSN-L)
  • 1447-0578
DOI
10.1002/rmb2.12088
PMC
PMC6046526
OpenAlex
W2793805814
Cited by
407
References
2
Citations by year
2026: 58 · 2025: 64 · 2024: 43 · 2023: 52 · 2022: 77 · 2021: 57 · 2020: 35 · 2019: 18 · 2018: 2
FWCI
2.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Reproductive Medicine and Biology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science (17K11260, 15K20169)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
decidualization, endometrium, endometrial stromal cells, progesterone, cyclic AMP, FOXO1, signal transducer and activator of transcription, embryo implantation, maternal-fetal interface, extracellular matrix remodeling, local immune response, oxidative stress, angiogenesis, pregnancy disorders, recurrent pregnancy loss, infertility

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