Cited by 351Reproductive Biology and FertilityReproductive Health and TechnologiesAntioxidant Activity and Oxidative Stress

Oxidative stress and antioxidants: exposure and impact on female fertility

Open access
Ruder, E. H., Hartman, T. J., Blumberg, J., Goldman, M. B.·2008·Human Reproduction Update

Abstract

BACKGROUND: Reproductive failure is a significant public health concern. Although relatively little is known about factors affecting fertility and early pregnancy loss, a growing body of literature suggests that environmental and lifestyle factors play an important role. There is sufficient evidence to hypothesize that diet, particularly its constituent antioxidants, and oxidative stress (OS) may influence the timing and maintenance of a viable pregnancy. We hypothesize that conditions leading to OS in the female affect time-to-pregnancy and early pregnancy loss. METHODS: We review the epidemiology of female infertility related to antioxidant defenses and oxidation and examine potential sources of OS from the ovarian germ cell through the stages of human pregnancy and pregnancy complications related to infertility. Articles were identified through a search of the PubMed database. RESULTS: Female OS is a likely mediator of conception and threshold levels for OS exist, dependent on anatomic location and stage of preconception. CONCLUSIONS: Prospective pregnancy studies with dietary assessment and collection of biological samples prior to conception with endpoints of time-to-pregnancy and early pregnancy loss are needed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/humupd/dmn011

Cites

160 of 160 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Human reproduction is complex but not very efficient, as less than one-third of fertilized human embryos have a chance of surviving up to term delivery.

    “Human reproduction is a complex but not very efficient process, as less than one -third of fertilized human embryos have a chance of surviving upto a term delivery (Ruder et al., 2008).”

    From Iron, Oxidative Stress and Health (2012) · cites this paper as Ruder et al., 2008

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 161 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Furnus CC, de Matos DG, Moses DF. Cumulus expansion during in vitro maturation of bovine oocytes: relationship with intracellular glutathione level and its role on subsequent embryo development. Mol Reprod Dev 1998;51:76-83.
  2. Goldman MB, Missmer SA, Barberi RL. Infertility. In Women and Helath, ed. Goldman MB, Hatch MC, San Diego: Academic Press, 2000, pp. 196-214.
  3. Kodaman PH, Behrman HR. Endocrine-regulated and protein kinase C-dependent generation of superoxide by rat preovulatory follicles. Endocrinology 2001;142:687-693.
  4. Paszkowski T, Clarke RN. Antioxidative capacity of preimplantation embryo culture medium declines following the incubation of poor quality embryos. Hum Reprod 1996;11:2493-2495.

Cited by

Sorted by citations

Authors
Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B.
Affiliations
  • Pennsylvania State University (US)
  • Tufts University (US)
  • Dartmouth–Hitchcock Medical Center (US)
Venue
Human Reproduction Update
Published
2008-04-02
Volume
14
Issue
4
Pages
345-357
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
OpenAlex
W2100338186
Cited by
351
References
161
Citations by year
2026: 7 · 2025: 20 · 2024: 14 · 2023: 16 · 2022: 19 · 2021: 31 · 2020: 33 · 2019: 21 · 2018: 22 · 2017: 29 · 2016: 26 · 2015: 23 · 2014: 23 · 2013: 17 · 2012: 13
FWCI
1.75
Type
journal article
Language
en
Open access
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Agriculture
  • National Institutes of Health
  • Agricultural Research Service
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049762)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
oxidative stress, antioxidants, female infertility, female fertility, time to pregnancy, early pregnancy loss, dietary antioxidants, ovarian germ cells, pregnancy complications, preconception exposure
MeSH terms
Abortion, Spontaneous, Antioxidants, Diet, Female, Fertilization, Humans, Infertility, Female, Oocytes, Ovulation, Embryo Implantation, Pregnancy, Reproduction, Reactive Oxygen Species, Oxidative Stress, Prenatal Nutritional Physiological Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review