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Hantavirus infections in Europe and their impact on public health
Open accessAbstract
SUMMARY: Hantaviruses (genus Hantavirus, family Bunyaviridae) are enveloped tri‐segmented negative‐stranded RNA viruses each carried by a specific rodent or insectivore host species. Several different hantaviruses known to infect humans circulate in Europe. The most common is Puumala (PUUV) carried by the bank vole; another two important, genetically closely related ones are Dobrava–Belgrade (DOBV) and Saaremaa viruses (SAAV) carried by Apodemus mice (species names follow the International Committee on Taxonomy of Viruses nomenclature). Of the two hantaviral diseases, hemorrhagic fever with renal syndrome (HFRS) and hantaviral cardiopulmonary syndrome, the European viruses cause only HFRS: DOBV with often severe symptoms and a high case fatality rate, and PUUV and SAAV more often mild disease. More than 10,000 HFRS cases are diagnosed annually in Europe and in increasing numbers. Whether this is because of increasing recognition by the medical community or due to environmental factors such as climate change, or both, is not known. Nevertheless, in large areas of Europe, the population has a considerable seroprevalence but only relatively few HFRS cases are reported. Moreover, no epidemiological data are available from many countries. We know now that cardiac, pulmonary, ocular and hormonal disorders are, besides renal changes, common during the acute stage of PUUV and DOBV infection. About 5% of hospitalized PUUV and 16%–48% of DOBV patients require dialysis and some prolonged intensive‐care treatment. Although PUUV–HFRS has a low case fatality rate, complications and long‐term hormonal, renal, and cardiovascular consequences commonly occur. No vaccine or specific therapy is in general use in Europe. We conclude that hantaviruses have a significant impact on public health in Europe. Copyright © 2012 John Wiley & Sons, Ltd.
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Citations
Cites
A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease
Jonsson, C. B., Figueiredo, L. T. M., & Vapalahti, O. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00062-09 · Cited by 1,134
Self-citationHantavirus Infections in Europe
Vapalahti, O., Mustonen, J., Lundkvist, Å., Henttonen, H., Plyusnin, A., & Vaheri, A. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00774-6 · Cited by 597
Self-citationHuggins, J. W., Hsiang, C. M., Cosgriff, T. M., Guang, M. Y., Smith, J. I., Wu, Z. O., LeDuc, J. W., Zheng, Z. M., Meegan, J. M., Wang, Q. N., et al. (1991) · Journal of Infectious Diseases · doi:10.1093/infdis/164.6.1119 · Cited by 463
Padula, P. J., Edelstein, A., Miguel, S. D. L., López, N. M., Rossi, C. M., & Rabinovich, R. D. (1998) · Virology · doi:10.1006/viro.1997.8976 · Cited by 422
Pucek, Z., Jędrzejewski, W., Jędrzejewska, B., & Pucek, M. (1993) · Acta Theriologica · doi:10.4098/at.arch.93-18 · Cited by 324
Relating increasing hantavirus incidences to the changing climate: the mast connection
Clement, J., Vercauteren, J., Verstraeten, W. W., Ducoffre, G., Barrios, J. M., Vandamme, A.-M., Maes, P., & Van Ranst, M. (2009) · International Journal of Health Geographics · doi:10.1186/1476-072x-8-1 · Cited by 288
Seed production and outbreaks of non-cyclic rodent populations in deciduous forests
Jensen, T. S. (1982) · Oecologia · doi:10.1007/bf00378391 · Cited by 207
Human pathogenic hantaviruses and prevention of infection
Krüger, D. H., Schönrich, G., & Klempa, B. (2011) · Human Vaccines · doi:10.4161/hv.7.6.15197 · Cited by 198
Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus
Mustonen, J. T., Partanen, J., Kanerva, M. J., PIETILÄ, K. A., Vapalahti, O. P., Pasternack, A. I., & Vaheri, A. (1996) · Kidney International · doi:10.1038/ki.1996.29 · Cited by 192
Self-citationTemonen, M., Mustonen, J., Helin, H., Pasternack, A., Vaheri, A., & Holthöfer, H. (1996) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.0007 · Cited by 176
Self-citationHantavirus disease (nephropathia epidemica) in Belgium: effects of tree seed production and climate
TERSAGO, K., VERHAGEN, R., SERVAIS, A., HEYMAN, P., DUCOFFRE, G., & LEIRS, H. (2009) · Epidemiology and Infection · doi:10.1017/s0950268808000940 · Cited by 173
Hantavirus in Bat, Sierra Leone
Weiss, S., Witkowski, P. T., Auste, B., Nowak, K., Weber, N., Fahr, J., Mombouli, J.-V., Wolfe, N. D., Drexler, J. F., Drosten, C., et al. (2012) · Emerging Infectious Diseases · doi:10.3201/eid1801.111026 · Cited by 162
Nephropathia Epidemica in Finland: A Retrospective Study of 126 Cases
Mustonen, J. T., Brummer‐Korvenkontio, M., Hedman, K., Pasternack, A. I., PIETILÄ, K. A., & Vaheri, A. I. (1994) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365549409008583 · Cited by 152
Self-citationPlyusnin, A., Hörling, J., Kanerva, M., Mustonen, J. T., Cheng, Y., Partanen, J., Vapalahti, O. P., Kukkonen, S. K. J., Niemimaa, J., Henttonen, H. A., et al. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.5.1090-1096.1997 · Cited by 151
Self-citationCyclic hantavirus epidemics in humans — Predicted by rodent host dynamics
Kallio, E. R. K., Begon, M. E., Henttonen, H. A., Koskela, E., Mappes, T., Vaheri, A. I., & Vapalahti, O. (2009) · Epidemics · doi:10.1016/j.epidem.2009.03.002 · Cited by 142
Self-citationLinard, C., Lamarque, P., Heyman, P., Ducoffre, G., Luyasu, V., Tersago, K., Vanwambeke, S., & Lambin, É. F. (2007) · International Journal of Health Geographics · doi:10.1186/1476-072x-6-15 · Cited by 135
Puumala Hantavirus Excretion Kinetics in Bank Voles (Myodes glareolus)
Hardestam, J., Karlsson, M., Falk, K. I., Olsson, G. E., Klingström, J., & Lundkvist, Å. (2008) · Emerging infectious diseases · doi:10.3201/eid1408.080221 · Cited by 132
Heyman, P., Ceianu, C. S., Christova, I., Tordo, N., Beersma, M. F., Alves, M. J., Lundkvist, Å., Hukić, M., Papa, A., Tenório, A., et al. (2011) · Eurosurveillance · doi:10.2807/ese.16.36.19961-en · Cited by 131
Self-citationHemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1
Klempa, B., Ткаченко, Е. А., Dzagurova, T. K., Yunicheva, Y. V., Morozov, V. G., Okulova, N. M., Slyusareva, G. P., Smirnov, A., & Krüger, D. H. (2008) · Emerging infectious diseases · doi:10.3201/eid1404.071310 · Cited by 128
Rasmuson, J., Andersson, C., Norrman, E., Haney, M., Evander, M., & Ahlm, C. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-1141-6 · Cited by 127
Clinical Characteristics of Nephropathia Epidemica in Sweden: Prospective Study of 74 Cases
Settergren, B., Juto, P., Trollfors, B., Wadell, G., & Norrby, S. R. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.6.921 · Cited by 124
Hantaviruses and Their Hosts in Europe: Reservoirs Here and There, But Not Everywhere?
Olsson, G. E., Leirs, H., & Henttonen, H. A. (2010) · Vector-Borne and Zoonotic Diseases · doi:10.1089/vbz.2009.0138 · Cited by 123
Self-citationKang, H. J., Bennett, S. N., Sumibcay, L., Arai, S., Hope, A. G., Mócz, G., Song, J., Cook, J. A., & Yanagihara, R. T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006149 · Cited by 120
Rusnak, J. M., Byrne, W. R., Chung, K. N., Gibbs, P., Kim, T. T., Boudreau, E. F., Cosgriff, T. M., Pittman, P. R., Kim, K. Y., Erlichman, M. S., et al. (2008) · Antiviral Research · doi:10.1016/j.antiviral.2008.09.007 · Cited by 117
Glass, G. E., Watson, A. J., LeDuc, J. W., Kelen, G. D., Quinn, T. C., & Childs, J. E. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.3.614 · Cited by 116
How to diagnose hantavirus infections and detect them in rodents and insectivores
Vaheri, A. I., Vapalahti, O., & Plyusnin, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.581 · Cited by 113
Self-citationHardestam, J., Simon, M., Hedlund, K. O., Vaheri, A. I., Klingström, J., & Lundkvist, Å. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02869-06 · Cited by 112
Self-citationEpidemiological Study of Nephropathia epidemica in Finland 1989-96
Vapalahti, O. (1999) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365549950163941 · Cited by 107
Self-citationEvander, M., Eriksson, I., Pettersson, L., Juto, P., Ahlm, C., Olsson, G. E., Bucht, G., & Allard, A. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01902-06 · Cited by 102
Mustonen, Partanen, J., Kanerva, Pietilä, Vapalahti, O. P., Pasternack, & Vaheri (1998) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1998.00302.x · Cited by 99
Self-citationOutbreak of Puumala Virus Infection, Sweden
Pettersson, L., Boman, J., Juto, P., Evander, M., & Ahlm, C. (2008) · Emerging infectious diseases · doi:10.3201/eid1405.071124 · Cited by 96
Extensive Host Sharing of Central European Tula Virus
Schmidt‐Chanasit, J., Essbauer, S. S., Petraitytė-Burneikienė, R., Yoshimatsu, K., Tackmann, K., Conraths, F. J., Sasnauskas, K., Arikawa, J., Thomas, A., Pfeffer, M., et al. (2009) · Journal of Virology · doi:10.1128/jvi.01226-09 · Cited by 91
Enhanced thrombin formation and fibrinolysis during acute Puumala hantavirus infection
Laine, O., Mäkelä, S., Mustonen, J. T., Huhtala, H., Szántó, T., Vaheri, A. I., Lassila, R., & Joutsi‐Korhonen, L. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.05.025 · Cited by 85
Self-citationEnvironmental conditions and Puumala virus transmission in Belgium
Linard, C., Tersago, K., Leirs, H., & Lambin, É. F. (2007) · International Journal of Health Geographics · doi:10.1186/1476-072x-6-55 · Cited by 84
Clement, J. P. G., Maes, P., Lagrou, K., Ranst, M. A. V., & Lameire, N. H. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1456-y · Cited by 83
Sin Nombre Viral RNA Load in Patients with Hantavirus Cardiopulmonary Syndrome
Xiao, R., Yang, S., Koster, F. T., Ye, C., Stidley, C. A., & Hjelle, B. L. (2006) · The Journal of Infectious Diseases · doi:10.1086/508494 · Cited by 82
Hantavirus Pulmonary Syndrome in New England and Europe
Brackett, L. E., Rotenberg, J., & Sherman, C. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408253310813 · Cited by 81
Terajima, M., Hayasaka, D., Maeda, K., & Ennis, F. A. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.08.003 · Cited by 80
Mäkelä, S., Mustonen, J. T., Ala-Houhala, I. O., Hurme, M., Koivisto, A., Vaheri, A. I., & Pasternack, A. I. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2003.12.044 · Cited by 80
Self-citationSaksida, A., Wraber, B., & Avšič‐Županc, T. (2011) · BMC Infectious Diseases · doi:10.1186/1471-2334-11-142 · Cited by 78
Case-control study on Puumala virus infection: smoking is a risk factor
Vapalahti, K., Virtala, A., Vaheri, A. I., & Vapalahti, O. (2009) · Epidemiology and Infection · doi:10.1017/s095026880999077x · Cited by 76
Self-citationA Case‐Control Study after a Hantavirus Infection Outbreak in the South of Belgium: Who Is at Risk?
Loock, F. V., Thomas, I., Clement, J. P. G., Ghoos, S., & Colson, P. (1999) · Clinical Infectious Diseases · doi:10.1086/515196 · Cited by 75
Déter, J., Bryja, J., Chaval, Y., Galan, M., Henttonen, H. A., Laakkonen, J., Voutilainen, L., Vapalahti, O., Vaheri, A. I., Ribas, A., et al. (2007) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2007.07.003 · Cited by 74
Self-citationHeyman, P., Vaheri, A. I., & members, E. (2008) · Eurosurveillance · doi:10.2807/ese.13.28.18925-en · Cited by 74
Self-citationTen-year prognosis of Puumala hantavirus-induced acute interstitial nephritis
Miettinen, M. H., Mäkelä, S., Ala-Houhala, I. O., Huhtala, H., Kööbi, T., Vaheri, A., Pasternack, A. I., Pörsti, I. H., & Mustonen, J. T. (2006) · Kidney International · doi:10.1038/sj.ki.5000334 · Cited by 73
Self-citationDobrava Virus RNA Load in Patients Who Have Hemorrhagic Fever with Renal Syndrome
Saksida, A., Duh, D., Korva, M., & Avšič‐Županc, T. (2008) · The Journal of Infectious Diseases · doi:10.1086/527485 · Cited by 71
Renal function and blood pressure five years after Puumala virus-induced nephropathy
Mäkelä, S., Ala-Houhala, I. O., Mustonen, J. T., Koivisto, A., Kouri, T., Turjanmaa, V., Vapalahti, O. P., Vaheri, A., & Pasternack, A. I. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00332.x · Cited by 67
Self-citationHantavirus RNA in Saliva from Patients with Hemorrhagic Fever with Renal Syndrome
Pettersson, L., Klingström, J., Hardestam, J., Lundkvist, Å., Ahlm, C., & Evander, M. (2008) · Emerging infectious diseases · doi:10.3201/eid1403.071242 · Cited by 66
Complement activation in Puumala hantavirus infection correlates with disease severity
Sane, J., Laine, O., Mäkelä, S., Paakkala, A., Jarva, H., Mustonen, J. T., Vapalahti, O., Meri, S., & Vaheri, A. I. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.573500 · Cited by 64
Self-citationPuumala Virus Infections in Finland: Increased Occupational Risk for Farmers
Vapalahti, K., Paunio, M., Brummer‐Korvenkontio, M., Vaheri, A. I., & Vapalahti, O. P. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009769 · Cited by 64
Self-citationCrowcroft, N. S., Infuso, A., Ilèf, D., Guenno, B. L., Jc, D., Loock, F. V., & Clement, J. P. G. (1999) · BMJ · doi:10.1136/bmj.318.7200.1737 · Cited by 61
Risk Factors for Human Infection with Puumala Virus, Southwestern Germany
Schwarz, A. C., Ranft, U., Piechotowski, I., Childs, J. E., & Brockmann, S. (2009) · Emerging infectious diseases · doi:10.3201/eid1507.081413 · Cited by 57
Risk Factors for Hantavirus Infection in Germany, 2005
(2007) · doi:10.3201/eid1309.070552 · Cited by 57
Guivier, E., Galan, M., Ribas, A., Xuéreb, A., Chaval, Y., Olsson, G. E., Essbauer, S. S., Henttonen, H. A., Voutilainen, L., Cosson, J., et al. (2010) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2010.07.022 · Cited by 54
Self-citationHigh Risk of Hypopituitarism in Patients Who Recovered from Hemorrhagic Fever with Renal Syndrome
Stojanović, M., Pekić, S., Cvijović, G., Miljić, D., Doknić, M., Nikolic-Djurovic, M., Micić, D., Hrvacevic, R., Nesic, V. B., & POPOVIC, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0311 · Cited by 50
Hormonal deficiencies during and after Puumala hantavirus infection
Mäkelä, S., Jaatinen, P., Miettinen, M. H., Salmi, J., Ala-Houhala, I. O., Huhtala, H., Hurme, M., Pörsti, I. H., Vaheri, A. I., & Mustonen, J. T. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-010-0918-y · Cited by 47
Self-citationLibraty, D. H., Mäkelä, S., Vlk, J., Hurme, M., Vaheri, A. I., Ennis, F. A., & Mustonen, J. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035402 · Cited by 43
Self-citationHLA-Associated Hemorrhagic Fever with Renal Syndrome Disease Progression in Slovenian Patients
Korva, M., Saksida, A., Jamnik, S. K., Vidan‐Jeras, B., & Avšič‐Županc, T. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.05187-11 · Cited by 43
Ahlm, C., Lindén, C., Linderholm, M., Alexeyev, O. A., Billheden, J., Elgh, F., Fagerlund, M., Zetterlund, B., & Settergren, B. (1998) · Journal of Infection · doi:10.1016/s0163-4453(98)80004-2 · Cited by 42
Seitsonen, E., Hynninen, M. S., Kolho, E., Kallio‐Kokko, H., & Pettilä, V. (2006) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-006-0117-z · Cited by 40
Dzagurova, T. K., Klempa, B., Ткаченко, Е. А., Slyusareva, G. P., Morozov, V. G., Auste, B., & Krüger, D. H. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.01225-09 · Cited by 40
Hypopituitarism as a Late Complication of Hemorrhagic Fever
Pekić, S., Cvijović, G., Stojanović, M., Kendereški, A., Micić, D., & POPOVIC, V. M. (2005) · Endocrine · doi:10.1385/endo:26:2:079 · Cited by 39
Platelet ligands and ADAMTS13 during Puumala hantavirus infection and associated thrombocytopenia
Laine, O., Mäkelä, S., Mustonen, J. T., Helminen, M., Vaheri, A. I., Lassila, R., & Joutsi‐Korhonen, L. (2011) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e328346a420 · Cited by 38
Self-citationSurvey and case-control study during epidemics of Puumala virus infection
Winter, C. H., Brockmann, S., Piechotowski, I., Alpers, K., der Heiden, M. A., Koch, J., Stark, K., & Pfaff, G. (2009) · Epidemiology and Infection · doi:10.1017/s0950268809002271 · Cited by 37
Huttunen, N., Mäkelä, S., Pokka, T. M.-L., Mustonen, J. T., & Uhari, M. K. (2011) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548.2011.559666 · Cited by 35
Self-citationMiettinen, M. H., Mäkelä, S., Ala-Houhala, I. O., Huhtala, H., Kööbi, T., Vaheri, A. I., Pasternack, A. I., Pörsti, I. H., & Mustonen, J. T. (2009) · Nephron Clinical Practice · doi:10.1159/000213899 · Cited by 34
Self-citationClinical characterization of Dobrava hantavirus infections in Germany.
Schütt, M., Gerke, P., Meisel, H., Ulrich, R. G., & Krüger, D. H. (2001) · PubMed · Cited by 31
Isolation of Sochi Virus From a Fatal Case of Hantavirus Disease With Fulminant Clinical Course
Dzagurova, T. K., Witkowski, P. T., Ткаченко, Е. А., Klempa, B., Морозов, В. Г., Auste, B., Zavora, D. L., Yunicheva, Y. V., Mutnih, E. S., & Krüger, D. H. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir746 · Cited by 29
Tulumović, D., Imamović, G., Mešić, E., Hukić, M., Tulumović, A., Imamović, A., & Zerem, E. (2009) · Nephrology · doi:10.1111/j.1440-1797.2009.01195.x · Cited by 20
Medical imaging in nephropathia epidemica and their clinical correlations
Paakkala, A., Lempinen, L., Paakkala, T., Huhtala, H., & Mustonen, J. T. (2004) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2004.07.001 · Cited by 20
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Metadata
- Authors
- Vaheri, A., Henttonen, H., Voutilainen, L., Mustonen, J., Sironen, T., & Vapalahti, O.
- Venue
- Reviews in Medical Virology
- Publisher
- Wiley
- Published
- 2012-07-03
- Volume
- 23
- Issue
- 1
- Pages
- 35-49
- ISSN
- 1052-9276 (ISSN-L)
- 1099-1654
- OpenAlex
- W1897525734
- Cited by
- 330
- References
- 70
- FWCI
- 18.41
- Type
- journal article
- Language
- en
- Open access
- green
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