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Prospective, Double-Blind, Concurrent, Placebo-Controlled Clinical Trial of Intravenous Ribavirin Therapy of Hemorrhagic Fever with Renal Syndrome
Abstract
A prospective, randomized, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin (loading dose of 33 mg/kg, 16 mg/kg every 6 h for 4 days, and 8 mg/kg every 8 h for 3 days) was conducted in 242 patients with serologically confirmed hemorrhagic fever with renal syndrome (HFRS) in the People's Republic of China. Mortality was significantly reduced (sevenfold decrease in risk) among ribavirin-treated patients, when comparisons were adjusted for baseline risk estimators of mortality (P = .01; two-tailed). HFRS typically consists of five consecutive but frequently overlapping clinical phases. Only occurrence of oliguric phase and hemorrhage was associated with severity of clinical disease in the placebo group. Ribavirin therapy also resulted in a significant reduction in the risk of entering the oliguric phase and experiencing hemorrhage. The only ribavirin-related side effect was a well-recognized, fully reversible anemia after completion of therapy.
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Cited by
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Kuenzli, A. B., Marschall, J., Schefold, J. C., Schafer, M., Engler, O. B., Ackermann-Gäumann, R., Reineke, D. C., Suter-Riniker, F., & Staehelin, C. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy443 · Cited by 34
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Metadata
- Authors
- Huggins, J. W., Hsiang, C. M., Cosgriff, T. M., Guang, M. Y., Smith, J. I., Wu, Z. O., LeDuc, J. W., Zheng, Z. M., Meegan, J. M., Wang, Q. N., Oland, D. D., Gui, X. E., Gibbs, P. H., Yuan, G. H., & Zhang, T. M.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-12-01
- Volume
- 164
- Issue
- 6
- Pages
- 1119-1127
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1970835801
- Cited by
- 463
- References
- 0
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Huggins, J. W., Hsiang, C. M., Cosgriff, T. M., Guang, M. Y., Smith, J. I., Wu, Z. O., LeDuc, J. W., Zheng, Z. M., Meegan, J. M., Wang, Q. N., Oland, D. D., Gui, X. E., Gibbs, P. H., Yuan, G. H., & Zhang, T. M. (1991). Prospective, Double-Blind, Concurrent, Placebo-Controlled Clinical Trial of Intravenous Ribavirin Therapy of Hemorrhagic Fever with Renal Syndrome. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/164.6.1119
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
