CoChat
Sign Up
Cited by 116Parvovirus B19 Infection StudiesInfectious Encephalopathies and EncephalitisViral Infections and Immunology Research

The DOI matches its Crossref record.

Neurological aspects of human parvovirus B19 infection: a systematic review

Open access
Barah, Faraj, Whiteside, Sigrid, Batista, Sonia, Morris, Julie·2014·Reviews in Medical Virology
DOI 10.1002/rmv.1782PMC PMC4238837
Open this paper in CoChat — free accountOpen PDF

Abstract

SUMMARY: Parvovirus B19 has been linked with various clinical syndromes including neurological manifestations. However, its role in the latter remains not completely understood. Although the last 10 years witnessed a surge of case reports on B19‐associated neurological aspects, the literature data remains scattered and heterogeneous, and epidemiological information on the incidence of B19‐associated neurological aspects cannot be accurately extrapolated. The aim of this review is to identify the characteristics of cases of B19‐associated neurological manifestations. A computerized systematic review of existing literature concerning cases of B19‐related neurological aspects revealed 89 articles describing 129 patients; 79 (61.2%) were associated with CNS manifestations, 41 (31.8%) were associated with peripheral nervous system manifestations, and 9 (7.0%) were linked with myalgic encephalomyelitis. The majority of the cases (50/129) had encephalitis. Clinical characteristic features of these cases were analyzed, and possible pathological mechanisms were also described. In conclusion, B19 should be included in differential diagnosis of encephalitic syndromes of unknown etiology in all age groups. Diagnosis should rely on investigation of anti‐B19 IgM antibodies and detection of B19 DNA in serum or CSF. Treatment of severe cases might benefit from a combined regime of intravenous immunoglobulins and steroids. To confirm these outcomes, goal‐targeted studies are recommended to exactly identify epidemiological scenarios and explore potential pathogenic mechanisms of these complications. Performing retrospective and prospective and multicenter studies concerning B19 and neurological aspects in general, and B19 and encephalitic syndromes in particular, are required. © 2014 The Authors. Reviews in Medical Virology published by John Wiley & Sons, Ltd.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/rmv.1782

Cites

Statistics

Figures

Figure 1 Flow diagram of information through the different phases of the review
Figure 1 Flow diagram of information through the different phases of the reviewCC BY-NC · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 106

  1. 10.1016/S0140-6736(75)91074-0 · DOI
  2. 10.1002/rmv.388 · DOI
  3. 10.1111/j.1365-2796.2011.02428.x · DOI
  4. 10.1016/j.jclinepi.2009.06.005 · DOI · Paper page
  5. 10.1016/S0022-3476(70)80059-2 · DOI
  6. Breese C, 1977, Encephalopathy with erythema infectiosum, American Journal of Diseases of Children, 131, 65
  7. 10.1007/BF01957931 · DOI
  8. 10.1136/adc.70.1.71-a · DOI
  9. 10.1007/s00431-004-1433-x · DOI
  10. 10.1016/S0140-6736(94)92014-1 · DOI
  11. 10.3109/00365549509047080 · DOI
  12. 10.1099/0022-1317-76-11-2645 · DOI
  13. 10.1097/00006454-199703000-00013 · DOI
  14. 10.3109/13550280009018306 · DOI
  15. 10.1016/S0140-6736(01)05905-0 · DOI
  16. 10.1111/j.1469-8749.2001.tb00190.x · DOI
  17. 10.1212/WNL.57.7.1336 · DOI
  18. 10.1067/mpd.2001.117070 · DOI
  19. 10.1016/S0303-8467(02)00030-6 · DOI
  20. 10.1136/adc.87.6.541 · DOI
  21. 10.1086/374603 · DOI
  22. 10.1007/s00467-004-1736-1 · DOI
  23. 10.1177/08830738060210092301 · DOI
  24. 10.1017/S0012162206001101 · DOI
  25. 10.1111/j.1399-3046.2006.00599.x · DOI
  26. 10.1111/j.1445-5994.2006.01038.x · DOI
  27. 10.1016/j.jcv.2006.11.004 · DOI
  28. Giørtz‐Carlsen B, 2007, Neurological symptoms and acute hepatitis associated with parvovirus B19, Ugeskrift for Laeger, 169, 4075
  29. 10.1086/589863 · DOI
  30. 10.1097/INF.0b013e3181694fcf · DOI
  31. Moretti MV, 2008, Acute infection with parvovirus B19 manifesting as brain stem encephalitis, Infections in Medicine, 25, 173
  32. 10.1111/j.1469-0691.2008.02110.x · DOI
  33. 10.1177/0883073808315420 · DOI
  34. 10.1111/j.1469-8749.2009.03388.x · DOI
  35. 10.1179/146532810X12858955921438 · DOI
  36. 10.3109/03009742.2011.617315 · DOI
  37. 10.1016/j.arcped.2011.08.013 · DOI
  38. 10.1097/INF.0b013e3182481e24 · DOI
  39. Lefrere J, 1985, Erythroblastopenia and febrile meningeal syndrome, Presse Médicale, 14, 228
  40. 10.1007/BF02009674 · DOI
  41. 10.1136/adc.68.6.784 · DOI
  42. 10.1007/BF02009384 · DOI
  43. 10.1136/fn.73.3.F196-c · DOI
  44. 10.1093/clinids/21.4.1053 · DOI
  45. 10.1086/520234 · DOI
  46. 10.1097/00006454-199904000-00024 · DOI
  47. 10.1590/S1413-86702001000100006 · DOI
  48. 10.1179/027249302125000166 · DOI
  49. 10.1136/adc.80.1.72 · DOI
  50. 10.1016/S0887-8994(02)00504-0 · DOI
  51. 10.1080/13550280490261752 · DOI
  52. Nagahama Y, 1992, An adult case of transverse myelitis with erythema infectiosum, Rinshō Shinkeigaku, 32, 1035
  53. Earl SC, 2007, A case of reactive arthritis secondary to parvovirus B19 infection complicated by an acute transverse myelitis, Rheumatology, 46, i139
  54. 10.1007/s00415-010-5536-1 · DOI
  55. 10.1097/00006454-199411000-00022 · DOI
  56. 10.1177/088307380401900413 · DOI
  57. 10.1155/2011/287914 · DOI
  58. 10.1016/j.pediatrneurol.2011.04.010 · DOI
  59. 10.1016/S1413-8670(11)70232-X · DOI
  60. 10.1136/jnnp.50.5.641 · DOI
  61. 10.1136/bmj.296.6626.896 · DOI
  62. 10.1016/0140-6736(93)91635-Y · DOI
  63. 10.1093/rheumatology/34.5.480 · DOI
  64. 10.1002/ana.410400618 · DOI
  65. 10.1136/ard.57.4.262 · DOI
  66. 10.1007/PL00008427 · DOI
  67. 10.1157/13092441 · DOI
  68. 10.1093/infdis/161.2.354 · DOI
  69. 10.1093/clind/15.4.595 · DOI
  70. 10.1016/j.medmal.2004.11.006 · DOI
  71. 10.1016/0140-6736(92)91096-Q · DOI
  72. 10.1056/NEJM200105103441919 · DOI
  73. 10.1016/j.jaad.2005.10.012 · DOI
  74. 10.1007/s00415-011-5931-2 · DOI
  75. 10.1016/j.braindev.2010.03.003 · DOI
  76. 10.1097/00006454-199903000-00025 · DOI
  77. 10.1590/S0004-282X2006000400015 · DOI
  78. 10.1055/s-2008-1035002 · DOI
  79. 10.1177/112067211002000428 · DOI
  80. 10.1093/clinids/22.1.162 · DOI
  81. 10.1136/ard.55.1.63 · DOI
  82. Kerr JR, 2002, Chronic fatigue syndrome and arthralgia following parvovirus B19 infection, Journal of Rheumatology, 29, 595
  83. 10.1136/jcp.2007.048140 · DOI
  84. 10.1016/j.rce.2011.09.004 · DOI
  85. 10.1016/S0163-4453(98)94531-5 · DOI
  86. Yamaoka Y, 2000, A case of Guillain–Barré syndrome (GBS) following human parvovirus B19 infection, Rinshō Shinkeigaku, 40, 471
  87. 10.1007/s00415-011-5949-5 · DOI
  88. Bucher Praz C, 2012, Guillain–Barré syndrome associated with primary parvovirus B19 infection in an HIV‐1‐infected patient, Medical Case Reports, 2012, 140780
  89. 10.1002/(SICI)1096-9071(199601)48:1<68::AID-JMV11>3.0.CO;2-2 · DOI
  90. 10.1093/rheumatology/39.8.903 · DOI
  91. 10.1086/513627 · DOI
  92. 10.2169/internalmedicine.42.903 · DOI
  93. 10.1097/01.inf.0000155194.66797.20 · DOI
  94. 10.1186/1743-422X-5-134 · DOI
  95. 10.1128/CMR.15.3.485-505.2002 · DOI
  96. 10.1136/jnnp.73.6.739 · DOI
  97. 10.1016/S0887-8994(99)00055-7 · DOI
  98. 10.1080/13550280600827351 · DOI
  99. 10.1007/s12311-009-0126-4 · DOI
  100. 10.1016/j.jpeds.2013.06.079 · DOI
  101. 10.12968/hmed.2010.71.9.78159 · DOI
  102. 10.1136/jnnp.51.5.613 · DOI
  103. 10.1002/art.1780380510 · DOI
  104. 10.1086/341774 · DOI
  105. 10.1099/vir.0.017590-0 · DOI
  106. 10.1086/374666 · DOI

Cited by

Sorted by citations

Metadata

Authors
Barah, F., Whiteside, S., Batista, S., & Morris, J.
Affiliations
  • Centro de Neurociências e Biologia Celular (PT)
  • Wythenshawe Hospital (GB)
  • Neurology Department Coimbra Hospital and University Centre Coimbra Portugal
Corresponding author
Barah, Faraj
ORCID
Venue
Reviews in Medical Virology
Publisher
Wiley
Published
2014-01-24
Volume
24
Issue
3
Pages
154-168
ISSN
  • 1052-9276 (ISSN-L)
  • 1099-1654
DOI
10.1002/rmv.1782
PMC
PMC4238837
OpenAlex
W1897605630
Cited by
116
References
0
Citations by year
2026: 11 · 2025: 11 · 2024: 11 · 2023: 13 · 2022: 13 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 12 · 2017: 4 · 2016: 9 · 2015: 9 · 2014: 3
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Reviews in Medical Virology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
financiado por Fundos FEDER através do Programa Operacional Factores de Competitividade - COMPETE e por Fundos Nacionais através da FCT - Fundação para a Ciência e a Tecnologia (WELCOMEII/6/CNC/1055/2011, PEst-C/SAU/LA0001/2013-2014)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parvovirus B19 Infection Studies
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Keywords
parvovirus B19, neurological symptoms, encephalitis, chronic fatigue syndrome, peripheral nerve involvement, central nervous system involvement, differential diagnosis, intravenous immunoglobulin, corticosteroids, pathophysiological mechanisms
MeSH terms
Antibodies, Viral, Central Nervous System, Diagnosis, Differential, DNA, Viral, Encephalitis, Humans, Parvoviridae Infections, Peripheral Nervous System Diseases, Steroids, Fatigue Syndrome, Chronic, Parvovirus B19, Human, Immunoglobulins, Intravenous

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review