The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise
Open accessAbstract
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for numerous clinical indications, including cancer, has significant promise. However, a considerable challenge for effective translation of these approaches is the limited tumor tropism and broad biodistribution observed using conventional MSCs, which raises concerns for toxicity to nontarget peripheral tissues (i.e., the bad). Consequently, there are a variety of synthetic engineering platforms in active development to improve tumor-selective targeting via increased homing efficiency and/or specificity of drug activation, some of which are already being evaluated clinically (i.e., the good). Unfortunately, the lack of robust quantification and widespread adoption of standardized methodologies with high sensitivity and resolution has made accurate comparisons across studies difficult, which has significantly impeded progress (i.e., the ugly). Herein, we provide a concise review of active and passive MSC homing mechanisms and biodistribution postinfusion; in addition to in vivo cell tracking methodologies and strategies to enhance tumor targeting with a focus on MSC-based drug delivery strategies for cancer therapy.
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Cites
Detection and quantification of mutations in the plasma of patients with colorectal tumors
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Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation
Prockop, D. J., & Youn Oh, J. (2012) · Molecular Therapy · doi:10.1038/mt.2011.211 · Cited by 816
Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells
Spaeth, E., Klopp, A., Dembinski, J., Andreeff, M., & Marini, F. (2008) · Gene Therapy · doi:10.1038/gt.2008.39 · Cited by 579
Klopp, A. H., Gupta, A., Spaeth, E., Andreeff, M., & Marini, F. (2011) · Stem Cells · doi:10.1002/stem.559 · Cited by 562
Adipose Tissue–Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy
Kucerova, L., Altanerova, V., Matuskova, M., Tyciakova, S., & Altaner, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4024 · Cited by 431
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Targeted Delivery of CX3CL1 to Multiple Lung Tumors by Mesenchymal Stem Cells
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Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model
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Cited by
Cao, J.-Y., Wang, B., Tang, T.-T., Wen, Y., Li, Z.-L., Feng, S.-T., Wu, M., Liu, D., Yin, D., Ma, K.-L., et al. (2021) · Theranostics · doi:10.7150/thno.54550 · Cited by 303
Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems
Su, S., & M. Kang, P. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090837 · Cited by 259
Zhuang, W.-Z., Lin, Y.-H., Su, L.-J., Wu, M.-S., Jeng, H.-Y., Chang, H.-C., Huang, Y.-H., & Ling, T.-Y. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00725-7 · Cited by 258
Mesenchymal stem cell homing to improve therapeutic efficacy in liver disease
Yuan, M., Hu, X., Yao, L., Jiang, Y., & Li, L. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02858-4 · Cited by 89
New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
Chang, X., Ma, Z., Zhu, G., Lu, Y., & Yang, J. (2021) · Journal of Bone Oncology · doi:10.1016/j.jbo.2021.100372 · Cited by 70
Metadata
- Authors
- Krueger, T. E. G., Thorek, D. L. J., Denmeade, S. R., Isaacs, J. T., & Brennen, W. N.
- Venue
- Stem Cells Translational Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-08-01
- Volume
- 7
- Issue
- 9
- Pages
- 651-663
- ISSN
- 2157-6564 (ISSN-L)
- 2157-6580
- OpenAlex
- W2887223157
- Cited by
- 240
- References
- 9
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise. https://app.cochat.ai/papers/10.1002/sctm.18-0024
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- Krueger, T. E. G., Thorek, D. L. J., Denmeade, S. R., Isaacs, J. T., & Brennen, W. N. (2018). Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise. Stem Cells Translational Medicine. https://doi.org/10.1002/sctm.18-0024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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