Cited by 297Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationBone Tissue Engineering Materials

The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches

Das, Ruud, Jahr, Holger, van Osch, Gerjo J.V.M., Farrell, Eric·2010·Tissue Engineering Part B Reviews

Abstract

Bone marrow-derived mesenchymal stem cells (MSCs) have demonstrated potential for regenerative medicine strategies. Knowledge of the way these cells respond to their environment in in vitro culture and after implantation in vivo is crucial for successful therapy. Oxygen tension plays a pivotal role in both situations. In vivo, a hypoxic environment can lead to apoptosis, but hypoxic preconditioning of MSCs and overexpression of prosurvival genes like Akt can reduce hypoxia-induced cell death. In cell culture, hypoxia can increase proliferation rates and enhance differentiation along the different mesenchymal lineages. Hypoxia also modulates the paracrine activity of MSCs, causing upregulation of various secretable factors, among which are important angiogenic factors such as vascular endothelial growth factor and interleukin-6 (IL6). Finally, hypoxia plays an important role in mobilization and homing of MSCs, primarily by its ability to induce stromal cell-derived factor-1 expression along with its receptor CXCR4. This article reviews the current literature on the effects of hypoxia on MSCs and aims to elucidate its potential role in regenerative medicine strategies.

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Crossref · 10.1089/ten.teb.2009.0296

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Authors
Das, R., Jahr, H., van Osch, G. J. V. M., & Farrell, E.
Affiliations
  • Erasmus MC (NL)
  • University Medical Center Rotterdam,
Corresponding author
Farrell, Eric
Venue
Tissue Engineering Part B Reviews
Published
2009-10-09
Volume
16
Issue
2
Pages
159-168
ISSN
  • 1937-3368 (ISSN-L)
  • 1937-3376
OpenAlex
W2017720509
Cited by
297
References
107
Citations by year
2026: 5 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 26 · 2017: 19 · 2016: 19 · 2015: 24 · 2014: 30 · 2013: 26 · 2012: 24
FWCI
8.55
Type
journal article
Language
en
Open access
closed
Locations
  • Tissue Engineering Part B Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
Dutch Arthritis Association
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
hypoxia, bone marrow-derived mesenchymal stem cells, oxygen partial pressure, hypoxic preconditioning, apoptosis, Akt signaling, cell proliferation, multilineage differentiation, paracrine signaling, angiogenic factors, vascular endothelial growth factor, interleukin-6, CXCL12, CXCR4, stem cell homing, stem cell mobilization, regenerative medicine
MeSH terms
Animals, Bone Marrow Cells, Cell Differentiation, Cell Survival, Humans, Models, Biological, Cell Hypoxia, Regenerative Medicine, Cell Proliferation, Mesenchymal Stem Cells

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