The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches
Abstract
Bone marrow-derived mesenchymal stem cells (MSCs) have demonstrated potential for regenerative medicine strategies. Knowledge of the way these cells respond to their environment in in vitro culture and after implantation in vivo is crucial for successful therapy. Oxygen tension plays a pivotal role in both situations. In vivo, a hypoxic environment can lead to apoptosis, but hypoxic preconditioning of MSCs and overexpression of prosurvival genes like Akt can reduce hypoxia-induced cell death. In cell culture, hypoxia can increase proliferation rates and enhance differentiation along the different mesenchymal lineages. Hypoxia also modulates the paracrine activity of MSCs, causing upregulation of various secretable factors, among which are important angiogenic factors such as vascular endothelial growth factor and interleukin-6 (IL6). Finally, hypoxia plays an important role in mobilization and homing of MSCs, primarily by its ability to induce stromal cell-derived factor-1 expression along with its receptor CXCR4. This article reviews the current literature on the effects of hypoxia on MSCs and aims to elucidate its potential role in regenerative medicine strategies.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hypoxia-mediated preconditioning of BM-MSCs can reduce hypoxia-induced cell death and increase BM-MSC proliferation and differentiation in vitro.
“hypoxia-mediated preconditioning of BM-MSCs could reduce hypoxia-induced cell death and increase BM-MSCs proliferation and differentiation [8] in vitro.”
From Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice (2014) · cites this paper as [8]
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works
Caplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559 · see citing works
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535 · see citing works
Human mesenchymal stem cells modulate allogeneic immune cell responses
Aggarwal, S., & Pittenger, M. F. (2005) · Blood · doi:10.1182/blood-2004-04-1559 · Cited by 4,511 · see citing works
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216 · see citing works
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992 · see citing works
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,724 · see citing works
Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro
Jaiswal, N., Haynesworth, S. E., Caplan, A. I., & Bruder, S. P. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(199702)64:2 · Cited by 2,547 · see citing works
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
Toma, C., Pittenger, M. F., Cahill, K. S., Byrne, B. J., & Kessler, P. (2002) · Circulation · doi:10.1161/hc0102.101442 · Cited by 2,234 · see citing works
Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues.
Friedenstein, A. J., Kv, P., KUROLESOVA, A. I., & Frolova, G. P. (1968) · PubMed · Cited by 1,921 · see citing works
HETEROTOPIC TRANSPLANTS OF BONE MARROW
Friedenstein, A. J., Kv, P., KUROLESOVA, A. I., & Frolova, G. P. (1968) · Transplantation · doi:10.1097/00007890-196803000-00009 · Cited by 1,703 · see citing works
Ma, Q., Jones, D., Borghesani, P. R., Segal, R. A., Nagasawa, T., Kishimoto, T., Bronson, R. T., & Springer, T. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9448 · Cited by 1,683 · see citing works
Osteogenesis in transplants of bone marrow cells
Friedenstein, A. J., Piatetzky-Shapiro, I. I., & Kv, P. (1966) · Development · doi:10.1242/dev.16.3.381 · Cited by 1,675 · see citing works
Mesenchymal stem cells: clinical applications and biological characterization
Barry, F., & Murphy, M. J. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.11.001 · Cited by 1,669 · see citing works
Chen, L., Tredget, E. E., Wu, P. Y. G., & Wu, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001886 · Cited by 1,610 · see citing works
Krampera, M., Glennie, S. J., Dyson, J., Scott, D. M., Laylor, R. M., Simpson, E., & Dazzi, F. (2003) · Blood · doi:10.1182/blood-2002-07-2104 · Cited by 1,597 · see citing works
Mangi, A. A., Noiseux, N., Kong, D., He, H., Rezvani, M., Ingwall, J. S., & Dzau, V. J. (2003) · Nature Medicine · doi:10.1038/nm912 · Cited by 1,510 · see citing works
Tepper, O. M., Galiano, R. D., Capla, J. M., Kalka, C., Gagne, P. J., Jacobowitz, G. R., Levine, J. P., & Gurtner, G. C. (2002) · Circulation · doi:10.1161/01.cir.0000039526.42991.93 · Cited by 1,447 · see citing works
Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics
Pittenger, M. F., & Martin, B. J. (2004) · Circulation Research · doi:10.1161/01.res.0000135902.99383.6f · Cited by 1,434 · see citing works
Kinnaird, T., Stabile, E., Burnett, M. S., Lee, C. W., Barr, S., Fuchs, S., & Epstein, S. E. (2004) · Circulation Research · doi:10.1161/01.res.0000118601.37875.ac · Cited by 1,415 · see citing works
Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats
Maniatopoulos, C., Sodek, J., & Melcher, A. H. (1988) · Cell and Tissue Research · doi:10.1007/bf00225804 · Cited by 1,322 · see citing works
Chondrogenic Differentiation of Cultured Human Mesenchymal Stem Cells from Marrow
Mackay, A. M., Beck, S. C., Murphy, M. J., Barry, F., Chichester, C. O., & Pittenger, M. F. (1998) · Tissue Engineering · doi:10.1089/ten.1998.4.415 · Cited by 1,302 · see citing works
Askari, A. T., Unzek, S., Popović, Z., Goldman, C. K., Forudi, F., Kiedrowski, M. J., Rovner, A., Ellis, S. G., Thomas, J. D., DiCorleto, P. E., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14232-8 · Cited by 1,269 · see citing works
Vascularization in tissue engineering
Rouwkema, J., Rivron, N. C., & van Blitterswijk, C. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.04.009 · Cited by 1,218 · see citing works
Systemic Delivery of Bone Marrow–Derived Mesenchymal Stem Cells to the Infarcted Myocardium
Barbash, I. M., Chouraqui, P., Baron, J., Feinberg, M. S., Etzion, S., Tessone, A., Miller, L., Guetta, E., Zipori, D., Kedes, L. H., et al. (2003) · Circulation · doi:10.1161/01.cir.0000084828.50310.6a · Cited by 1,196 · see citing works
Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction
Shintani, S., Murohara, T., Ikeda, H., Ueno, T., Honma, T., Katoh, A., Sasaki, K., Shimada, T., Oike, Y., & Imaizumi, T. (2001) · Circulation · doi:10.1161/hc2301.092122 · Cited by 1,185 · see citing works
Gnecchi, M., He, H., Noiseux, N., Liang, O. D., Zhang, L., Morello, F., Mu, H., Melo, L. G., Pratt, R. E., Ingwall, J. S., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5211com · Cited by 1,158 · see citing works
Stem cell therapy in a caprine model of osteoarthritis
Murphy, M. J., Fink, D. J., Hunziker, E. B., & Barry, F. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11365 · Cited by 1,103 · see citing works
Friedenstein, A. J., Uf, D., Nn, K., Af, P., Sf, R., Ea, L., & Ia, R. (1974) · PubMed · Cited by 1,015 · see citing works
Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers
Friedenstein, A. J., Chailakhyan, R. K., & Gerasimov, U. V. (1987) · Cell Proliferation · doi:10.1111/j.1365-2184.1987.tb01309.x · Cited by 984 · see citing works
Cardiomyocyte Grafting for Cardiac Repair: Graft Cell Death and Anti-Death Strategies
Zhang, M., Methot, D., Poppa, V., Fujio, Y., Walsh, K., & Murry, C. E. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1367 · Cited by 878 · see citing works
Plasticity of marrow-derived stem cells
Herzog, E. L., Chai, L., & Krause, D. S. (2003) · Blood · doi:10.1182/blood-2003-05-1664 · Cited by 841 · see citing works
Rosová, I., Dao, M. A., Capoccia, B. J., Link, D. C., & Nolta, J. A. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1104 · Cited by 690 · see citing works
Son, B., Marquez‐Curtis, L. A., Kucia, M., Wysoczynski, M., Turner, A. R., Ratajczak, J., Ratajczak, M. Z., & Janowska‐Wieczorek, A. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0271 · Cited by 641 · see citing works
Hu, X., Yu, S. P., Fraser, J. L., Lu, Z., Ogle, M. E., Wang, J., & Wei, L. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.07.071 · Cited by 623 · see citing works
Ryan, J. M., Barry, F., Murphy, M. J., & Mahon, B. P. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03422.x · Cited by 596 · see citing works
Osteoblast and chondroblast differentiation
Aubin, J. E., Liu, F., Malaval, L., & Gupta, A. (1995) · Bone · doi:10.1016/8756-3282(95)00183-e · Cited by 596 · see citing works
Kadiyala, S. (1997) · Cell Transplantation · doi:10.1016/s0963-6897(96)00279-5 · Cited by 554 · see citing works
Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
Grayson, W. L., Zhao, F., Bunnell, B., & Ma, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.054 · Cited by 521 · see citing works
Crisostomo, P. R., Wang, Y., Markel, T. A., Wang, M., Lahm, T., & Meldrum, D. R. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00437.2007 · Cited by 460 · see citing works
Hung, S.-C., Pochampally, R. R., Chen, S.-C., Hsu, S.-C., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0686 · Cited by 457 · see citing works
Bcl-2 Engineered MSCs Inhibited Apoptosis and Improved Heart Function
Li, W., Ma, N., Ong, L., Neßelmann, C., Klopsch, C., Ladilov, Y. V., Furlani, D., Piechaczek, C., Moebius, J. M., Lützow, K., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0771 · Cited by 439 · see citing works
Lennon, D. P., Edmison, J. M., & Caplan, A. I. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1081 · Cited by 425 · see citing works
Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs
Grayson, W. L., Zhao, F., Izadpanah, R., Bunnell, B. A., & Ma, T. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20571 · Cited by 409 · see citing works
Hypoxia and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells
Zhu, W., Chen, J., Cong, X., Hu, S., & Chen, X. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0121 · Cited by 399 · see citing works
Tang, Y., Tang, Y., Zhang, Y. C., Qian, K., Shen, L., & Phillips, M. I. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.05.079 · Cited by 392 · see citing works
Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells
D’Ippolito, G., Diabira, S., Howard, G. A., Roos, B. A., & Schiller, P. C. (2006) · Bone · doi:10.1016/j.bone.2006.02.061 · Cited by 389 · see citing works
Interaction of Nuclear Receptors with the Wnt/β-Catenin/Tcf Signaling Axis: Wnt You Like to Know?
Mulholland, D. J., Dedhar, S., Coetzee, G. A., & Nelson, C. C. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0034 · Cited by 377 · see citing works
The role of hypoxia in the maintenance of hematopoietic stem cells
Cipolleschi, M., Sbarba, P. D., & Olivotto, M. (1993) · Blood · doi:10.1182/blood.v82.7.2031.2031 · Cited by 373 · see citing works
Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells
Groh, M. E., Maitra, B., Szekely, E., & Koç, O. N. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.05.002 · Cited by 372 · see citing works
Hypoxia or in situ normoxia: The stem cell paradigm
Ivanovic, Z. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21690 · Cited by 346 · see citing works
Hung, S., Pochampally, R. R., Hsu, S., Sanchez, C., Chen, S.-C., Spees, J. L., & Prockop, D. J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000416 · Cited by 317 · see citing works
Robins, J. C., Akeno, N., Mukherjee, A., Dalal, R. R., Aronow, B. J., Koopman, P. A., & Clemens, T. L. (2005) · Bone · doi:10.1016/j.bone.2005.04.040 · Cited by 317 · see citing works
Multipotential Mesenchymal Stem Cells Are Mobilized into Peripheral Blood by Hypoxia
Rochefort, G. Y., Delorme, B., López, A., Hérault, O., Bonnet, P., Charbord, P., Eder, V., & Domenech, J. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0164 · Cited by 315 · see citing works
Hypoxia Promotes Murine Bone‐Marrow‐Derived Stromal Cell Migration and Tube Formation
Annabi, B., Lee, Y., Turcotte, S., Naud, E., Desrosiers, R. R., Champagne, M. A., Eliopoulos, N., Galipeau, J., & Béliveau, R. (2003) · Stem Cells · doi:10.1634/stemcells.21-3-337 · Cited by 302 · see citing works
Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression
Potier, E., Ferreira, E., Andriamanalijaona, R., Pujol, J. ‐., Oudina, K., Logeart‐Avramoglou, D., & Petite, H. (2007) · Bone · doi:10.1016/j.bone.2006.11.024 · Cited by 295 · see citing works
Oxygen in the Cultivation of Stem Cells
CSETE, M. E. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1334.001 · Cited by 269 · see citing works
Wang, Y., Deng, Y., & Zhou, G. (2008) · Brain Research · doi:10.1016/j.brainres.2007.11.068 · Cited by 266 · see citing works
Kanichai, M., Ferguson, D., Prendergast, P. J., & Campbell, V. A. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21446 · Cited by 262 · see citing works
Iwase, T., Nagaya, N., Fujii, T., Itoh, T., MURAKAMI, S., Matsumoto, T., Kangawa, K., & KITAMURA, S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.006 · Cited by 258 · see citing works
Theus, M. H., Wei, L., Cui, L., Francis, K. R., Hu, X., Keogh, C. L., & Yu, S. P. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.12.020 · Cited by 247 · see citing works
Hypoxia and stem cell‐based engineering of mesenchymal tissues
Ma, T., Grayson, W. L., Fröhlich, M., & Vunjak‐Novakovic, G. (2009) · Biotechnology Progress · doi:10.1002/btpr.128 · Cited by 231 · see citing works
Potier, E., Ferreira, E., Meunier, A., Sedel, L., Logeart‐Avramoglou, D., & Petite, H. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0325 · Cited by 223 · see citing works
Ohnishi, S., Yasuda, T., Kitamura, S., & Nagaya, N. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0347 · Cited by 222 · see citing works
Salim, A., Nacamuli, R. P., Morgan, E. F., Giaccia, A. J., & Longaker, M. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403715200 · Cited by 221 · see citing works
Cell based bone tissue engineering in jaw defects
Meijer, G. J., de Bruijn, J. D., Koole, R., & van Blitterswijk, C. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.03.012 · Cited by 207 · see citing works
Inhibition of Rho-Kinase Attenuates Hypoxia-Induced Angiogenesis in the Pulmonary Circulation
Hyvelin, J.-M., Howell, K., Nichol, A., Costello, C. M., Preston, R. J., & McLoughlin, P. (2005) · Circulation Research · doi:10.1161/01.res.0000174287.17953.83 · Cited by 207 · see citing works
Feasibility of a stem cell therapy for intervertebral disc degeneration
Sobajima, S., Vadalà, G., Shimer, A. L., Kim, J. S., Gilbertson, L. G., & Kang, J. D. (2007) · The Spine Journal · doi:10.1016/j.spinee.2007.09.011 · Cited by 201 · see citing works
Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions
Ren, H., Cao, Y., Zhao, Q., Li, J., Zhou, C.-X., Liao, L., Jia, M., Zhao, Q., Cai, H., Han, Z., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.169 · Cited by 201 · see citing works
Oxygen Tension Regulates Chondrocyte Differentiation and Function during Endochondral Ossification
Hirao, M., Tamai, N., Tsumaki, N., Yoshikawa, H., & Myoui, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602296200 · Cited by 192 · see citing works
Hoogduijn, M. J., Crop, M. J., Peeters, A. M. A., van Osch, G. J. V. M., Balk, A. H. M. M., IJzermans, J. N. M., Weimar, W., & Baan, C. C. (2007) · Stem Cells and Development · doi:10.1089/scd.2006.0110 · Cited by 189 · see citing works
Metabolic Flexibility Permits Mesenchymal Stem Cell Survival in an Ischemic Environment
Mylotte, L. A., Duffy, A. M., Murphy, M. J., O’Brien, T., Afshin Samali, A., Barry, F., & Szegezdi, É. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1072 · Cited by 183 · see citing works
Induction of Adipocyte‐Like Phenotype in Human Mesenchymal Stem Cells by Hypoxia
Fink, T., Abildtrup, L. A., Fogd, K., Abdallah, B. M., Kassem, M. S., Ebbesen, P., & Zachar, V. (2004) · Stem Cells · doi:10.1634/stemcells.2004-0038 · Cited by 179 · see citing works
Regenerative and immunomodulatory potential of mesenchymal stem cells
Krampera, M., Pasini, A. M. F., Pizzolo, G., Cosmi, L., Romagnani, S., & Annunziato, F. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.02.008 · Cited by 177 · see citing works
Regulation of Endothelial Matrix Metalloproteinase-2 by Hypoxia/Reoxygenation
Ben-Yosef, Y., Lahat, N., Shapiro, S., Bitterman, H., & Miller, A. (2002) · Circulation Research · doi:10.1161/01.res.0000015588.70132.dc · Cited by 173 · see citing works
Bone Mesenchymal Stem Cells Transplanted into Rabbit Intervertebral Discs Can Increase Proteoglycans
Zhang, Y., Guo, X., Xu, P., Kang, L., & Li, J. (2005) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000146534.31120.cf · Cited by 171 · see citing works
Martin‐Rendon, E., Hale, S. J. M., Ryan, D. J., Baban, D. F., Forde, S. P., Roubelakis, M. G., Sweeney, D., Moukayed, M., Harris, A. L., Davies, K. E., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0398 · Cited by 167 · see citing works
Carrancio, S., López-Holgado, N., Sanchez-Guijo, F. M., Villarón, E. M., Barbado, M. V., Tabera, S., Díez‐Campelo, M., Blanco, J. F., Miguel, J. F. S., & del Cañizo, M. C. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.03.012 · Cited by 153 · see citing works
Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells
Wang, J., Chen, T., Jiang, J., Shi, H., Gui, C., Luo, R., Xie, X.-J., Xiang, M., & Zhang, X. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00716.x · Cited by 146 · see citing works
Chondrogenic Priming of Human Bone Marrow Stromal Cells: A Better Route to Bone Repair?
Farrell, E., van der Jagt, O. P., Koevoet, W. J. L. M., Kops, N., van Manen, C. J., Hellingman, C. A., Jahr, H., O’Brien, F. J., Verhaar, J. A. N., Weinans, H., et al. (2008) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2008.0297 · Cited by 132 · see citing works
Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms
Hokari, M., Kuroda, S., Shichinohe, H., Yano, S., Hida, K., & Iwasaki, Y. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21572 · Cited by 126 · see citing works
Mesenchymal stem cells and cardiac repair
Neßelmann, C., Ma, N., Bieback, K., Wagner, W., Ho, A. D., Konttinen, Y. T., Zhang, H., Hinescu, M. E., & Steinhoff, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00457.x · Cited by 121 · see citing works
Ji, J. F., He, B. P., Dheen, S. T., & Tay, S. S. W. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.024 · Cited by 112 · see citing works
Critical Effect of Oxygen Tension on Rate of Growth of Animal Cells in Continuous Suspended Culture
Cooper, P. D., Burt, A., & WILSON, J. N. (1958) · Nature · doi:10.1038/1821508b0 · Cited by 91 · see citing works
Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation
Crop, M. J., Baan, C. C., Weimar, W., & Hoogduijn, M. J. (2008) · Transplant International · doi:10.1111/j.1432-2277.2008.00786.x · Cited by 86 · see citing works
Ottino, P., Finley, J., Rojo–Niersbach, E. G., Ottlecz, A., Lambrou, G. N., Bazán, H. E. P., & Bazan, N. G. (2004) · PubMed · Cited by 85 · see citing works
Jiang, S., Haider, H. K., Ahmed, R. P. H., Idris, N. M., Salim, A., & Ashraf, M. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.11.014 · Cited by 81 · see citing works
Xu, R., Chen, J., Cong, X., Hu, S., & Chen, X. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21402 · Cited by 78 · see citing works
Scherer, K., Schünke, M., Sellckau, R., Hassenpflug, J., & Kurz, B. (2004) · Biorheology · doi:10.1177/0006355x2004041003004015 · Cited by 77 · see citing works
Yun, S. P., Lee, M. Y., Ryu, J. M., Song, C. H., & Han, H. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00415.2008 · Cited by 75 · see citing works
Liu, X.-H., Bai, C., Xu, Z., Huang, S., Yuan, Y., Gong, D., & Zhang, J. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.02.005 · Cited by 74 · see citing works
Müller, I., Vaegler, M., Holzwarth, C., Tzaribachev, N., Pfister, S. M., Schüett, B. S., Reize, P., Greil, J., Handgretinger, R., & Rudert, M. (2008) · Leukemia · doi:10.1038/leu.2008.217 · Cited by 69 · see citing works
Ūsas, A., Ho, A. M., Cooper, G. M., Olshanski, A., Peng, H., & Huard, J. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0130 · Cited by 59 · see citing works
Lord‐Dufour, S., Copland, I. B., Levros, L.-C., Post, M., Das, A., Khosla, C., Galipeau, J., Rassart, É., & Annabi, B. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0855 · Cited by 56 · see citing works
Verseijden, F., Jahr, H., Sluijs, S. J. P.-V., ten Hagen, T. L. M., Hovius, S. E. R., Seynhaeve, A. L. B., van Neck, J. W., van Osch, G. J. V. M., & Hofer, S. O. P. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0429 · Cited by 50 · see citing works
Li, T., Takahashi, M., Ohshima, M., Qin, S., Kubo, M., Muramatsu, K., & Hamano, K. (2008) · Cell Transplantation · doi:10.3727/096368908786092702 · Cited by 42 · see citing works
Factors affecting growth and glycolysis in tissue culture.
Zwartouw, H. T., & Westwood, J. C. N. (1958) · PubMed · Cited by 42 · see citing works
Lysophosphatidic Acid Protects Mesenchymal Stem Cells Against Ischemia-Induced Apoptosis In Vivo
Liu, X., Hou, J., Shi, L., Chen, J., Sang, J., Hu, S., Cong, X., & Chen, X. (2009) · Stem Cells and Development · doi:10.1089/scd.2008.0352 · Cited by 41 · see citing works
Differentiation of rat osteoblast-like cells in monolayer and micromass cultures
Gerber, I., & Gwynn, I. A. (2002) · European Cells and Materials · doi:10.22203/ecm.v003a03 · Cited by 35 · see citing works
Xu, R., Chen, X., Chen, J., Han, Y., & Han, B. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05041.x · Cited by 30 · see citing works
Expansion of hematopoietic stem/progenitor cells
Wu, H., Xin‐Na, D., & Duan, H. (2008) · American Journal of Hematology · doi:10.1002/ajh.21262 · Cited by 30 · see citing works
Chronic hypoxia induces nonreversible right ventricle dysfunction and dysplasia in rats
Bonnet, P., Bonnet, S., Boissière, J., Net, J.-L. L., Gautier, M., de la Roque, E. D., & Eder, V. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00802.2003 · Cited by 30 · see citing works
Cell Grafting for Cardiac Repair
Reinecke, H., & Murry, C. E. (2003) · Humana Press eBooks · doi:10.1385/1-59259-350-x:97 · Cited by 29 · see citing works
Muir, C., Chung, L. W. K., Carson, D. D., & Farach‐Carson, M. C. (2006) · Clinical & Experimental Metastasis · doi:10.1007/s10585-006-9021-2 · Cited by 28 · see citing works
Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis
Gui, C., Wang, J. A., He, A. N., Chen, T. L., Luo, R. H., Jiang, J., Hu, X. Y., & Xie, X. J. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9541-3 · Cited by 17 · see citing works
[Effect of hypoxia on the gene profile of human bone marrow-derived mesenchymal stem cells].
Wu, E.-H., Li, H.-S., Zhao, T., Fan, J.-D., Ma, X., Xiong, L., Li, W.-J., Zhu, L., & Fan, M. (2007) · PubMed · Cited by 16 · see citing works
Angiogenic potency of bone marrow stromal cells improved byex vivo hypoxia prestimulation
Xiaobo, M., Qiutang, Z., Xiang, W., Linsheng, C., & Zhifeng, B. (2004) · Current Medical Science · doi:10.1007/bf02911356 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hass, R., Kasper, C., Böhm, S., & Jacobs, R. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-12 · Cited by 1,756 · see citing works
Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning
Ferreira, J. R., Teixeira, G. Q., Santos, S. G., Barbosa, M. A., Almeida-Porada, G., & Gonçalves, R. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02837 · Cited by 572 · see citing works
Bora, P., & Majumdar, A. S. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0598-y · Cited by 550 · see citing works
Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration
Nitzsche, F., Müller, C., Łukomska, B., Jolkkonen, J., Deten, A., & Boltze, J. (2017) · Stem Cells · doi:10.1002/stem.2614 · Cited by 384 · see citing works
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Weiss, D. J., Kolls, J. K., Ortiz, L. A., Panoskaltsis‐Mortari, A., & Prockop, D. J. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200804-037dw · Cited by 308 · see citing works
Baldari, S., Rocco, G. D., Piccoli, M., Pozzobon, M., Muraca, M., & Toietta, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102087 · Cited by 281 · see citing works
Liu, H., Liu, S., Li, Y., Wang, X., Xue, W., Ge, G., & Luo, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034608 · Cited by 262 · see citing works
Chen, L., Xu, Y., Zhao, J., Zhang, Z., Yang, R., Xie, J., Liu, X., & Qi, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096161 · Cited by 251 · see citing works
Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1α in MSCs
Liu, H., Xue, W., Ge, G., Luo, X., Li, Y., Xiang, H., Ding, X., Tian, P., & Tian, X. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.09.076 · Cited by 243 · see citing works
Krueger, T. E. G., Thorek, D. L. J., Denmeade, S. R., Isaacs, J. T., & Brennen, W. N. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0024 · Cited by 243 · see citing works
Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells
Lavrentieva, A., Majore, I., Kasper, C., & Hass, R. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-18 · Cited by 241 · see citing works
Beegle, J. R., Lakatos, K., Kalomoiris, S., Stewart, H., Isseroff, R. R., Nolta, J. A., & Fierro, F. A. (2015) · Stem Cells · doi:10.1002/stem.1976 · Cited by 236 · see citing works
The Effect of Hypoxia on Mesenchymal Stem Cell Biology
Ejtehadifar, M., Shamsasenjan, K., Movassaghpour, A., Akbarzadehlaleh, P., Dehdilani, N., Abbasi, P., Molaeipour, Z., & Saleh, M. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.021 · Cited by 235 · see citing works
Laganà, A. S., Vitale, S. G., Salmeri, F. M., Triolo, O., Ban Frangež, H., Vrtačnik-Bokal, E., Stojanovska, L., Apostolopoulos, V., Granese, R., & Sofo, V. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.03.032 · Cited by 221 · see citing works
Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization
Rademakers, T., Horvath, J. M., van Blitterswijk, C., & LaPointe, V. L. S. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2932 · Cited by 219 · see citing works
Hadanny, A., & Efrati, S. (2020) · Biomolecules · doi:10.3390/biom10060958 · Cited by 216 · see citing works
Transplantation of Cord Blood Mesenchymal Stem Cells as Spheroids Enhances Vascularization
Bhang, S. H., Lee, S., Shin, J., Lee, T., & Kim, B. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0640 · Cited by 203 · see citing works
Chacko, S. M., Ahmed, S., Selvendiran, K., Kuppusamy, M. L., Khan, M., & Kuppusamy, P. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00221.2010 · Cited by 200 · see citing works
Singh, A., Singh, A., & Sen, D. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0341-0 · Cited by 194 · see citing works
Preconditioning Strategy in Stem Cell Transplantation Therapy
Yu, S. P., Wei, Z. Z., & Wei, L. (2013) · Translational Stroke Research · doi:10.1007/s12975-012-0251-0 · Cited by 190 · see citing works
Zhang, Q., Nguyen, A. L., Shi, S., Hill, C. K., Wilder-Smith, P. B. B., Krasieva, T. B., & Le, A. D. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0252 · Cited by 188 · see citing works
Cell based therapies for ischemic stroke: From basic science to bedside
Liu, X., Ye, R., Yan, T., Yu, S. P., Wei, L., Xu, G., Fan, X., Jiang, Y., Stetler, R. A., Liu, C., et al. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.007 · Cited by 179 · see citing works
Chen, L., Xu, Y., Zhao, J., Zhang, Z., Yang, R., Xie, J., Liu, X., & Qi, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145565 · Cited by 174 · see citing works
Stem Cells and Cell Therapies in Lung Biology and Lung Diseases
Weiss, D. J., Bertoncello, I., Borok, Z., Kim, C., Panoskaltsis‐Mortari, A., Reynolds, S., Rojas, M., Stripp, B. R., Warburton, D., & Prockop, D. J. (2011) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201012-071dw · Cited by 170 · see citing works
Zinc(II) phthalocyanines as photosensitizers for antitumor photodynamic therapy
Roguin, L. P., Chiarante, N., Vior, M. C. G., & Marino, J. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105575 · Cited by 158 · see citing works
Fan, Z., Xu, Z., Niu, H., Gao, N., Guan, Y., Li, C., Dang, Y., Cui, X., Liu, X.-Y., Duan, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-19906-w · Cited by 134 · see citing works
Yeatts, A. B., Choquette, D. T., & Fisher, J. P. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.06.007 · Cited by 134 · see citing works
Sun, J., Wei, Z. Z., Gu, X., Zhang, J. Y., Zhang, Y., Li, J., & Wei, L. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.011 · Cited by 133 · see citing works
Diekman, B. O., Wu, C., Louer, C. R., Furman, B. D., Huebner, J. L., Kraus, V. B., Olson, S. A., & Guilak, F. (2012) · Cell Transplantation · doi:10.3727/096368912x653264 · Cited by 133 · see citing works
Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
Hu, C., Zhao, L., Zhang, L., Bao, Q., & Li, L. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01895-1 · Cited by 130 · see citing works
Preconditioning and Stem Cell Survival
Haider, H. K., & Ashraf, M. (2009) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-009-9161-2 · Cited by 129 · see citing works
Salazar-Noratto, G. E., Luo, G., Denoeud, C., Padrona, M., Moya, A., Bensidhoum, M., Bizios, R., Potier, E., Logeart‐Avramoglou, D., & Petite, H. (2019) · Stem Cells · doi:10.1002/stem.3079 · Cited by 120 · see citing works
Mesenchymal Stem Cell Paracrine Factors in Vascular Repair and Regeneration
Pankajakshan, D., & Agrawal, D. K. (2014) · Journal of Biomedical Technology and Research · doi:10.19104/jbtr.2014.107 · Cited by 120 · see citing works
Sullivan, K. E., Quinn, K. P., Tang, K. M., Georgakoudi, I., & Black, L. D. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt403 · Cited by 117 · see citing works
Engineering exosomes and biomaterial-assisted exosomes as therapeutic carriers for bone regeneration
Lu, Y., Mai, Z., Cui, L., & Zhao, X. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03275-x · Cited by 119 · see citing works
Boregowda, S. V., Krishnappa, V., Chambers, J. W., Lograsso, P. V., Lai, W., Ortiz, L. A., & Phinney, D. G. (2012) · STEM CELLS · doi:10.1002/stem.1069 · Cited by 114 · see citing works
Empowering Adult Stem Cells for Myocardial Regeneration
Mohsin, S., Siddiqi, S., Collins, B. L., & Sussman, M. A. (2011) · Circulation Research · doi:10.1161/circresaha.111.243071 · Cited by 109 · see citing works
Stamati, K., Mudera, V., & Cheema, U. (2011) · Journal of Tissue Engineering · doi:10.1177/2041731411432365 · Cited by 107 · see citing works
Hydrogels and Dentin–Pulp Complex Regeneration: From the Benchtop to Clinical Translation
Abbass, M. M. S., El‐Rashidy, A. A., Sadek, K. M., Moshy, S. E., Radwan, I. A., Rady, D., Dörfer, C. E., & El‐Sayed, K. M. F. (2020) · Polymers · doi:10.3390/polym12122935 · Cited by 110 · see citing works
Jiang, C., Liu, J., Zhao, J., Xiao, L., An, S., Gou, Y., Quan, H. X., Cheng, Q., Zhang, Y. L., He, W., et al. (2014) · Journal of Dental Research · doi:10.1177/0022034514557671 · Cited by 106 · see citing works
Meng, S., Xu, X., Chang, W., Lu, Z., Huang, L., Xu, J., Liu, L., Qiu, H.-B., Yang, Y., & Guo, F. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1031-x · Cited by 105 · see citing works
Discrepancies on the Role of Oxygen Gradient and Culture Condition on Mesenchymal Stem Cell Fate
Samal, J. R. K., Rangasami, V. K., Samanta, S., Varghese, O. P., & Oommen, O. P. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002058 · Cited by 96 · see citing works
Tissue-Engineered Cartilage: The Crossroads of Biomaterials, Cells and Stimulating Factors
Bhardwaj, N., Devi, D., & Mandal, B. B. (2014) · Macromolecular Bioscience · doi:10.1002/mabi.201400335 · Cited by 99 · see citing works
Yu, X., Lu, C., Liu, H., Rao, S., Cai, J., Liu, S., Kriegel, A. J., Greene, A. S., Liang, M., & Ding, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062703 · Cited by 93 · see citing works
Ho, S. S., Hung, B. P., Heyrani, N., Lee, M. A., & Leach, J. K. (2018) · Stem Cells · doi:10.1002/stem.2853 · Cited by 91 · see citing works
Teixeira, F. G., Panchalingam, K. M., Anjo, S. I., Manadas, B., Pereira, R., Sousa, N., Salgado, A. J., & Behie, L. A. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0124-z · Cited by 87 · see citing works
Song, M., Mohamad, O., Gu, X., Wei, L., & Yu, S. P. (2012) · Cell Transplantation · doi:10.3727/096368912x657909 · Cited by 85 · see citing works
Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential
Pei, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.049 · Cited by 83 · see citing works
Feng, Y., Zhu, M., Dangelmajer, S., Lee, Y. M., Wijesekera, O., Castellanos, C. X., Denduluri, A. J., Chaichana, K. L., Li, Q., Zhang, H., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.521 · Cited by 80 · see citing works
Moroni, L., & Fornasari, P. M. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24223 · Cited by 79 · see citing works
Mesenchymal Stem Cells for the Treatment of Liver Disease: Present and Perspectives
Kang, S. H., Kim, M. Y., Eom, Y. W., & Baik, S. K. (2020) · Gut and Liver · doi:10.5009/gnl18412 · Cited by 78 · see citing works
Hypoxia Impedes Hypertrophic Chondrogenesis of Human Multipotent Stromal Cells
Gawlitta, D., van Rijen, M. H. P., Schrijver, E. J. M., Alblas, J., & Dhert, W. J. A. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0657 · Cited by 77 · see citing works
HIF-1α Overexpression Induces Angiogenesis in Mesenchymal Stem Cells
Razban, V., Lotfi, A. S., Soleimani, M., Ahmadi, H., Massumi, M., Khajeh, S., Ghaedi, M., Arjmand, S., Najavand, S., & Khoshdel, A. (2012) · BioResearch open access · doi:10.1089/biores.2012.9905 · Cited by 77 · see citing works
Choi, J. R., Yong, K. W., & Zaman, W. S. W. K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2484-2 · Cited by 77 · see citing works
Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells
Efimenko, A. Y., Kochegura, T. N., Akopyan, Z. A., & Parfyonova, Y. V. (2015) · BioResearch open access · doi:10.1089/biores.2014.0042 · Cited by 76 · see citing works
Huang, B., Qian, J., Ma, J., Huang, Z., Shen, Y., Chen, X., Sun, A., Ge, J., & Chen, H. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt410 · Cited by 76 · see citing works
A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer
Levy, O., Brennen, W. N., Han, E., Rosen, D. M., Musabeyezu, J., Safaee, H., Ranganath, S. H., Ngai, J., Heinelt, M., Milton, Y., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.023 · Cited by 75 · see citing works
Interleukin-1β modulates endochondral ossification by human adult bone marrow stromal cells
Mumme, M., Scotti, C., Papadimitropoulos, A., Todorov, A., Hoffmann, W., Bocelli‐Tyndall, C., Jakob, M., Wendt, D. J., Martín, I., & Barbero, A. (2012) · European Cells and Materials · doi:10.22203/ecm.v024a16 · Cited by 71 · see citing works
Mesenchymal stromal cells: promising treatment for liver cirrhosis
Yao, L., Hu, X., Dai, K., Yuan, M., Liu, P., Zhang, Q., & Jiang, Y. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03001-z · Cited by 71 · see citing works
Li, Q., Zhang, A., Tao, C., Li, X., & Jin, P. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.071 · Cited by 71 · see citing works
Rocco, G. D., Gentile, A., Antonini, A., Ceradini, F., Wu, J. C., Capogrossi, M. C., & Toietta, G. (2010) · Stem Cells International · doi:10.4061/2011/304562 · Cited by 70 · see citing works
Hypoxia Inducible Factor-Stabilizing Bioactive Glasses for Directing Mesenchymal Stem Cell Behavior
Azevedo, M. M., Tsigkou, O., Nair, R., Jones, J. R., Jell, G., & Stevens, M. M. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0083 · Cited by 70 · see citing works
Hoke, N. N., Salloum, F. N., Kass, D. A., Das, A., & Kukreja, R. C. (2011) · Stem Cells · doi:10.1002/stem.789 · Cited by 70 · see citing works
Zhao, L., Hu, C., Zhang, P., Jiang, H., & Chen, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14035 · Cited by 70 · see citing works
Sharma, P. M., Kumar, A., Dey, A. D., Behl, T., & Chadha, S. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118932 · Cited by 69 · see citing works
Yamamoto, Y., Fujita, M., Tanaka, Y., Kojima, I., Kanatani, Y., Ishihara, M., & Tachibana, S. (2013) · BioResearch open access · doi:10.1089/biores.2013.0004 · Cited by 69 · see citing works
Mesenchymal Stem Cells: Roles and Relationships in Vascularization
Melchiorri, A. J., Nguyen, B. B., & Fisher, J. P. (2014) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2013.0541 · Cited by 68 · see citing works
Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro
Jing, D., Wobus, M., Poitz, D. M., Bornhäuser, M., Ehninger, G., & Ordemann, R. (2011) · Haematologica · doi:10.3324/haematol.2011.050815 · Cited by 64 · see citing works
Demol, J., Lambrechts, D., Geris, L., Schrooten, J., & Oosterwyck, H. V. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.093 · Cited by 64 · see citing works
Weiss, D. J. (2013) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201304-090aw · Cited by 62 · see citing works
Cruz, M. A., Dissaranan, C., Cotleur, A. C., Kiedrowski, M. J., Penn, M. S., & Damaser, M. S. (2011) · Obstetrics and Gynecology International · doi:10.1155/2012/612946 · Cited by 61 · see citing works
Exosomes from preconditioned mesenchymal stem cells: Tissue repair and regeneration
Long, R., & Wang, S. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.01.009 · Cited by 62 · see citing works
Fernández, M. P. R., Calvo‐Guirado, J. L., de Val, J. E. M. S., Ruiz, R. A. D., Negrí, B., Zamora, G. P., Peñarrocha‐Oltra, D., Barona, C., Marín, J. M. G., & Alcaraz, M. (2012) · Clinical Oral Investigations · doi:10.1007/s00784-012-0684-6 · Cited by 60 · see citing works
RetractedMesenchymal stem cells: potential application in intervertebral disc regeneration.
Wei, A., Shen, B., Williams, L. A., & Diwan, A. D. (2014) · PubMed Central · doi:10.3978/j.issn.2224-4336.2014.03.05 · Cited by 59 · see citing works
Inducible Metabolic Adaptation Promotes Mesenchymal Stem Cell Therapy for Ischemia
Zhu, H., Sun, A., Zou, Y., & Ge, J. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303194 · Cited by 58 · see citing works
Zayed, M., Iohara, K., Watanabe, H., Ishikawa, M., Tominaga, M., & Nakashima, M. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02240-w · Cited by 56 · see citing works
Hypoxic condition enhances chondrogenesis in synovium-derived mesenchymal stem cells
Bae, H. C., Park, H. J., Wang, S. Y., Yang, H. R., Lee, M. C., & Han, H. (2018) · Biomaterials Research · doi:10.1186/s40824-018-0134-x · Cited by 56 · see citing works
Lee, J., Park, J., Kim, T.-W., Jung, B.-J., Lee, Y., Shim, E.-K., Park, S., Choi, E. Y., Cho, K., & Kim, C. (2015) · Bone · doi:10.1016/j.bone.2015.04.044 · Cited by 55 · see citing works
Hypoxia and HIFs in regulating the development of the hematopoietic system
Imanirad, P., & Dzierzak, E. A. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.08.005 · Cited by 54 · see citing works
Wise, J. K., Alford, A. I., Goldstein, S. A., & Stegemann, J. P. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0151 · Cited by 53 · see citing works
Metabolic regulation of mesenchymal stem cell in expansion and therapeutic application
Liu, Y., & Ma, T. (2014) · Biotechnology Progress · doi:10.1002/btpr.2034 · Cited by 53 · see citing works
Zhu, L., Dissanayaka, W. L., & Zhang, C. (2018) · Clinical Oral Investigations · doi:10.1007/s00784-018-2699-0 · Cited by 53 · see citing works
Enhancement strategies for mesenchymal stem cells and related therapies
Alagesan, S., Brady, J., Byrnes, D., Fandiño, J., Masterson, C. H., McCarthy, S., Laffey, J. G., & O’Toole, D. P. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02747-w · Cited by 57 · see citing works
Kay, A. G., Dale, T. P., Akram, K. M., Mohan, P., Hampson, K., Maffulli, N., Spiteri, M. A., Haj, A. J. E., & Forsyth, N. R. (2015) · Regenerative Medicine · doi:10.2217/rme.14.67 · Cited by 49 · see citing works
Sarkissian, S. D., Lévesque, T., & Noiseux, N. (2017) · World Journal of Stem Cells · doi:10.4252/wjsc.v9.i1.9 · Cited by 49 · see citing works
Zhao, L., Hu, C., Zhang, P., Jiang, H., & Chen, J. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14769 · Cited by 47 · see citing works
Pharmacologically active microcarriers influence VEGF ‐A effects on mesenchymal stem cell survival
Penna, C. R. R., Perrelli, M.-G., Karam, J., Angotti, C., Muscari, C., Montero‐Menei, C. N., & Pagliaro, P. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01662.x · Cited by 46 · see citing works
Richardson, J. D., Bertaso, A., Psaltis, P. J., Frost, L., Carbone, A., Paton, S., Nelson, A. J., Wong, D. T. L., Worthley, M. I., Gronthos, S., et al. (2013) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2013.03.011 · Cited by 46 · see citing works
Yang, H.-M., Song, W., Li, Q., Kim, S., Kim, H., Ryu, M., Ahn, J., & Youn, H. (2018) · Research in Veterinary Science · doi:10.1016/j.rvsc.2018.05.011 · Cited by 46 · see citing works
Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy
Patel, A. N., & Genovese (2011) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s11991 · Cited by 45 · see citing works
Oxygenated Environment Enhances Both Stem Cell Survival and Osteogenic Differentiation
Benjamin, S., Sheyn, D., Ben‐David, S., Oh, A., Kallai, I., Li, N., Gazit, D., & Gazit, Z. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0298 · Cited by 45 · see citing works
Regenerative Potential of Mesenchymal Stem Cells’ (MSCs) Secretome for Liver Fibrosis Therapies
Ignat, S.-R., Gharbia, S., Hermenean, A. O., Dinescu, S., & Costache, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413292 · Cited by 46 · see citing works
Endogenous Bone Regeneration Is Dependent Upon a Dynamic Oxygen Event
Sammarco, M. C., Simkin, J., Fassler, D., Cammack, A. J., Wilson, A. C., Meter, K. V., & Muneoka, K. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2261 · Cited by 44 · see citing works
Stem cell-based therapy: Improving myocardial cell delivery
Feyen, D. A. M., Gaetani, R., Doevendans, P. A., & Sluijter, J. P. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.023 · Cited by 45 · see citing works
Effects of CoCl2on multi-lineage differentiation of C3H/10T1/2 mesenchymal stem cells
Yoo, H., Moon, Y. H., & Kim, M. (2016) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2016.20.1.53 · Cited by 43 · see citing works
Li, Q., GUO, Y., Chen, F., Liu, J., & Jin, P. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3309 · Cited by 42 · see citing works
Shaw, T. D., Krasnodembskaya, A. D., Schroeder, G. N., Zumla, A. I., Maeurer, M. J., & O’Kane, C. M. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00064-21 · Cited by 42 · see citing works
Yang, B., Brahmbhatt, A. N., Torres, E. N., Thielen, B. V., McCall, D. L., Engel, S., Bansal, A., Pandey, M. K., Dietz, A. B., Leof, E. B., et al. (2015) · Radiology · doi:10.1148/radiol.2015150947 · Cited by 42 · see citing works
Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent
Shephard, M. T., Merkhan, M. M., & Forsyth, N. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113596 · Cited by 42 · see citing works
Mahjoor, M., Fakouri, A., Farokhi, S., Nazari, H., Afkhami, H., & Heidari, F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1245872 · Cited by 42 · see citing works
- Authors
- Das, R., Jahr, H., van Osch, G. J. V. M., & Farrell, E.
- Affiliations
- Erasmus MC (NL)
- University Medical Center Rotterdam,
- Corresponding author
- Farrell, Eric
- Venue
- Tissue Engineering Part B Reviews
- Publisher
- SAGE Publications
- Published
- 2009-10-09
- Volume
- 16
- Issue
- 2
- Pages
- 159-168
- ISSN
- 1937-3368 (ISSN-L)
- 1937-3376
- OpenAlex
- W2017720509
- Cited by
- 297
- References
- 107
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 26 · 2017: 19 · 2016: 19 · 2015: 24 · 2014: 30 · 2013: 26 · 2012: 24
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tissue Engineering Part B Reviews (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Dutch Arthritis Association
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- hypoxia, bone marrow-derived mesenchymal stem cells, oxygen partial pressure, hypoxic preconditioning, apoptosis, Akt signaling, cell proliferation, multilineage differentiation, paracrine signaling, angiogenic factors, vascular endothelial growth factor, interleukin-6, CXCL12, CXCR4, stem cell homing, stem cell mobilization, regenerative medicine
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Cell Survival, Humans, Models, Biological, Cell Hypoxia, Regenerative Medicine, Cell Proliferation, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review