The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Covariate heterogeneity in meta‐analysis: Criteria for deciding between meta‐regression and individual patient data
Abstract
Meta‐analyses of clinical trials are increasingly seeking to go beyond estimating the effect of a treatment and may also aim to investigate the effect of other covariates and how they alter treatment effectiveness. This requires the estimation of treatment‐covariate interactions. Meta‐regression can be used to estimate such interactions using published data, but it is known to lack statistical power, and is prone to bias. The use of individual patient data can improve estimation of such interactions, among other benefits, but it can be difficult and time‐consuming to collect and analyse. This paper derives, under certain conditions, the power of meta‐regression and IPD methods to detect treatment–covariate interactions. These power formulae are shown to depend on heterogeneity in the covariate distributions across studies. This allows the derivation of simple tests, based on heterogeneity statistics, for comparing the statistical power of the analysis methods. Copyright © 2006 John Wiley & Sons, Ltd.
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Meta-analysis: Principles and procedures
Egger, M., Smith, G. D., & Phillips, A. N. (1997) · BMJ · doi:10.1136/bmj.315.7121.1533 · Cited by 2,415
QUANTITATIVE METHODS IN THE REVIEW OF EPIDEMIOLOGIC LITERATURE1
GREENLAND, S. (1987) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036298 · Cited by 1,644
Cited by
Van Kerkhove, M. D., Vandemaele, K. A. H., Shinde, V., Jaramillo-Gutierrez, G., Koukounari, A., Donnelly, C. A., Carlino, L. O., Owen, R., Paterson, B., Pelletier, L., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001053 · Cited by 706
Bally, M., Dendukuri, N., Rich, B., Nadeau, L., Helin-Salmivaara, A., Garbe, E., & Brophy, J. M. (2017) · BMJ · doi:10.1136/bmj.j1909 · Cited by 528
Dias, S., Sutton, A. J., Welton, N. J., & Ades, A. E. (2013) · Medical Decision Making · doi:10.1177/0272989x13485157 · Cited by 466
Bower, P., Kontopantelis, E., Sutton, A., Kendrick, T., Richards, D. A., Gilbody, S., Knowles, S., Cuijpers, P., Andersson, G., Christensen, H., et al. (2013) · BMJ · doi:10.1136/bmj.f540 · Cited by 341
Get real in individual participant data (IPD) meta‐analysis: a review of the methodology
Debray, T. P. A., Moons, K. G. M., van Valkenhoef, G., Efthimiou, O., Hummel, N., Groenwold, R. H. H., Reitsma, J. B., & on behalf of the GetReal methods review group (2015) · Research Synthesis Methods · doi:10.1002/jrsm.1160 · Cited by 348
Metadata
- Authors
- Simmonds, M. C., & Higgins, J. P. T.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 2006-12-29
- Volume
- 26
- Issue
- 15
- Pages
- 2982-2999
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W2160672817
- Cited by
- 194
- References
- 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
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