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Extending DerSimonian and Laird's methodology to perform multivariate random effects meta‐analyses

Jackson, Dan, White, Ian R., Thompson, Simon G.·2010·Statistics in Medicine

Abstract

Multivariate meta‐analysis is increasingly used in medical statistics. In the univariate setting, the non‐iterative method proposed by DerSimonian and Laird is a simple and now standard way of performing random effects meta‐analyses. We propose a natural and easily implemented multivariate extension of this procedure which is accessible to applied researchers and provides a much less computationally intensive alternative to existing methods. In a simulation study, the proposed procedure performs similarly in almost all ways to the more established iterative restricted maximum likelihood approach. The method is applied to some real data sets and an extension to multivariate meta‐regression is described. Copyright © 2009 John Wiley & Sons, Ltd.

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Research works printed but not linked: 30

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Metadata

Authors
Jackson, D., White, I. R., & Thompson, S. G.
Venue
Statistics in Medicine
Publisher
Wiley
Published
2010-05-19
Volume
29
Issue
12
Pages
1282-1297
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
OpenAlex
W2144373793
Cited by
594
References
8
FWCI
16.72
Type
journal article
Language
en
Open access
closed
Licence
Funders
UK Medical Research Council (U.1052.00.006, U.1052.00.001)

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