The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Methods for combining randomized clinical trials: Strengths and limitations
Abstract
Methods for combining data from several studies exist and appear to be quite useful. None satisfactorily addresses the question of what studies should be combined. This issue is the most serious methodological limitation. Even studies with statistically significant interaction might still be combined if the effect were in the same direction. Thus, substantial scientific input is required as to what criteria must be met by each potential study. Much can be learned from combining or pooling data but it must be done cautiously. Pooling exercises do not replace well designed prospective clinical trials. Efforts for establishing basic design criteria to allow for multicentre and multicountry trials to be more easily combined might be useful.
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Cites
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
Some Methods for Strengthening the Common χ 2 Tests
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001616 · Cited by 3,718
Beta blockade during and after myocardial infarction: An overview of the randomized trials
Yusuf, S., Peto, R., Lewis, J., Collins, R., & Sleight, P. (1985) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(85)80003-7 · Cited by 3,205
Cited by
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924
Vitamin D supplementation for prevention of mortality in adults
Bjelakovic, G., Gluud, L. L., Nikolova, D., Whitfield, K., Wetterslev, J., Simonetti, R. G., Bjelakovic, M., & Gluud, C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007470.pub3 · Cited by 695
Takeshima, N., Sozu, T., Tajika, A., Ogawa, Y., Hayasaka, Y., & Furukawa, T. A. (2014) · BMC Medical Research Methodology · doi:10.1186/1471-2288-14-30 · Cited by 387
Hemmingsen, B., Lund, S. S., Gluud, C., Vaag, A., Almdal, T., Hemmingsen, C., & Wetterslev, J. (2011) · BMJ · doi:10.1136/bmj.d6898 · Cited by 386
Metadata
- Authors
- Demets, D. L.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 1987-04
- Volume
- 6
- Issue
- 3
- Pages
- 341-348
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W2086148792
- Cited by
- 1,027
- References
- 3
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Demets, D. L. (1987). Methods for combining randomized clinical trials: Strengths and limitations. Statistics in Medicine. https://doi.org/10.1002/sim.4780060325
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