Aspects of the use of relative risk models in the design and analysis of cohort studies and prevention trials
Abstract
Relative risk regression methods provide a unifying and powerful approach to a range of problems in the design and analysis of cohort studies and prevention trials. Standard partial likelihood-based estimation procedures do not, however, encompass several features that are important in such contexts. Specifically, one may wish to relate disease rates marginally to 'recent' risk factor measurements, whereas a partial likelihood approach requires one to condition on an accumulating risk factor history. Secondly, risk factor values may be ascertained with considerable measurement error, thereby requiring specialized procedures to estimate relative risk parameters. Thirdly, analysis of raw materials to obtain desired covariate (risk factor) histories may involve considerable expense if carried out for the entire cohort. Case-control and case-cohort sampling procedures can avoid much of this expense, but once again partial likelihood estimation procedures require generalization. Such generalizations are described herein.
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The case-cohort design was accounted for by Prentice weighting.
“The case-cohort design was accounted for by Prentice weighting (26).”
From Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes (2015) · cites this paper as [26]
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FACULTAT DE MEDICINA I ODONTOLOGÍA
Medicina, D. D. (2014)
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Domínguez‐López, I., Eichelmann, F., Parilli‐Moser, I., Hurtado‐Barroso, S., Lamuela-Raventós, R. M., & Schulze, M. B. (2026) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2026.101527
- Authors
- Prentice, R. L., & Self, S. G.
- Affiliations
- Fred Hutch Cancer Center (US)
- ORCID
- Prentice, Ross L.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 1988-01
- Volume
- 7
- Issue
- 1-2
- Pages
- 275-287
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W2155401038
- Cited by
- 30
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 1 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Statistics in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM 24472)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Inference
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- relative risk model, cohort studies, prevention trials, measurement error, case-control sampling
- MeSH terms
- Blood Pressure, Cardiovascular Diseases, Cerebral Hemorrhage, Cerebral Infarction, Coronary Disease, Humans, Japan, Models, Biological, Regression Analysis, Research Design, Risk Factors, Statistics as Topic
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