Cited by 30Statistical Methods in EpidemiologyStatistical Methods and InferenceStatistical Methods in Clinical Trials

Aspects of the use of relative risk models in the design and analysis of cohort studies and prevention trials

Prentice, Ross L., Self, Steven G.·1988·Statistics in Medicine

Abstract

Relative risk regression methods provide a unifying and powerful approach to a range of problems in the design and analysis of cohort studies and prevention trials. Standard partial likelihood-based estimation procedures do not, however, encompass several features that are important in such contexts. Specifically, one may wish to relate disease rates marginally to 'recent' risk factor measurements, whereas a partial likelihood approach requires one to condition on an accumulating risk factor history. Secondly, risk factor values may be ascertained with considerable measurement error, thereby requiring specialized procedures to estimate relative risk parameters. Thirdly, analysis of raw materials to obtain desired covariate (risk factor) histories may involve considerable expense if carried out for the entire cohort. Case-control and case-cohort sampling procedures can avoid much of this expense, but once again partial likelihood estimation procedures require generalization. Such generalizations are described herein.

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Crossref · 10.1002/sim.4780070127

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Authors
Prentice, R. L., & Self, S. G.
Affiliations
Fred Hutch Cancer Center (US)
Venue
Statistics in Medicine
Publisher
Wiley
Published
1988-01
Volume
7
Issue
1-2
Pages
275-287
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
OpenAlex
W2155401038
Cited by
30
References
24
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 1 · 2015: 3 · 2014: 2 · 2013: 1
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Locations
  • Statistics in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (GM 24472)
Topics
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Inference
  • Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Keywords
relative risk model, cohort studies, prevention trials, measurement error, case-control sampling
MeSH terms
Blood Pressure, Cardiovascular Diseases, Cerebral Hemorrhage, Cerebral Infarction, Coronary Disease, Humans, Japan, Models, Biological, Regression Analysis, Research Design, Risk Factors, Statistics as Topic

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