Mastering variation: Variance components and personalised medicine

Cited by (205)

Items 101–200 of 205

1. Treatment effect heterogeneity of cognitive behavioral therapy for insomnia – A meta-analysis
   Lisa Steinmetz, Laura Simon, Harald Baumeister, Kai Spiegelhalder, Yannik Terhorst · 2024 · Sleep Medicine Reviews
2. Personalised carbohydrate feeding during exercise based on exogenous glucose oxidation: a proof-of-concept study
   Tim Podlogar, Natasha Cooper-Smith, Javier Thomas Gonzalez, Gareth A. Wallis · 2025 · Performance Nutrition
3. Design and analysis considerations for utilizing a mapping function in a small sample, sequential, multiple assignment, randomized trials with continuous outcomes
   Holly E. Hartman, Roy Tamura, Matthew J. Schipper, KM Kidwell · 2020 · Statistics in Medicine
4. Influence of Lumbar Mobilizations During the Nordic Hamstring Exercise on Hamstring Measures of Knee Flexor Strength, Failure Point, and Muscle Activity: A Randomized Crossover Trial
   Paul Chesterton, Will Evans, Matthew Wright, Lorenzo Lolli, Mark C. Richardson, Greg Atkinson · 2020 · Journal of Manipulative and Physiological Therapeutics
5. What Is the Numerical Nature of Pain Relief?
   Andrew David Vigotsky, Siddharth R. Tiwari, James William Griffith, A. Vania Apkarian · 2021 · Frontiers in Pain Research
6. In Pursuit of Precision Medicine in the Critically Ill
   Manu Shankar‐Hari, Charlotte Summers, John Kenneth Baillie · 2018 · Annual update in intensive care and emergency medicine
7. Clozapine as an early‐stage treatment
   Philipp Homan, John Michael Kane · 2018 · Acta Psychiatrica Scandinavica
8. Individual Responses to Repeated Dosing with Anthocyanin-Rich New Zealand Blackcurrant Extract During High-Intensity Intermittent Treadmill Running in Active Males
   Ian Perkins, Sam David Blacker, Mark E. T. Willems · 2024 · Nutrients
9. Exploration of associations between the FTO rs9939609 genotype, fasting and postprandial appetite-related hormones and perceived appetite in healthy men and women
   Fernanda Reistenbach Goltz, Alice Emily Thackray, Verónica Varela-Mato, James A. King, James L. Dorling, Monika Dowejko, Sarabjit Singh Mastana, Julie Thompson, Greg Atkinson, David J. Stensel · 2019 · Appetite
10. Heavy resistance exercise training in older men: A responder and inter-individual variability analysis
    Casper Soendenbroe, Jesper L. Andersen, Mette F. Heisterberg, Michael Kjær, Abigail Louise Mackey · 2026 · PLoS ONE
11. Does evidence support the high expectations placed in precision medicine? A bibliographic review
    Jordi Cortés, José Antonio González, María Nuncia Medina, Markus Vogler, Marta Vilaró, Matt Elmore, Stephen John Senn, Michael Joseph Campbell, Erik Cobo · 2018 · F1000Research
12. A replicate crossover trial on the interindividual variability of sleep indices in response to acute exercise undertaken by healthy men
    Yuting Yang, Alice Emily Thackray, Tonghui Shen, Tareq F. Alotaibi, Turki M. Alanazi, Tom Clifford, Iuliana Hartescu, James A. King, Matthew J Roberts, Scott A. Willis et al. · 2024 · SLEEP
13. Is Variance Ratio a Valid Indicator of Heterogeneous Treatment Effect?
    Sunjae Bae · 2019 · JAMA Psychiatry
14. Conformal prediction intervals for the individual treatment effect
    Danijel Kivaranovic, Robin Ristl, Martin Posch, Hannes Leeb · 2020 · arXiv (Cornell University)
15. Identifying non‐responders to treatments for myopia
    Jeremy A. Guggenheim, Jeffrey J. Walline · 2023 · Ophthalmic and Physiological Optics
16. Immediate effects of Ramadan on objective time asleep in male youth football players from the Middle East: an interrupted time-series study
    Lorenzo Lolli, Warren A. Gregson, Adam Pulford, Tane Kanope, Emmanuel Lopez, Valter Di Salvo · 2024 · Science and Medicine in Football
17. Is personalization of psychological pain treatments necessary? Evidence from a Bayesian variance ratio meta-analysis
    Saskia Scholten, Philipp Herzog, Julia Anna Glombiewski, Tim Kaiser · 2024 · Pain
18. Are there interindividual differences in the reactive hypoglycaemia response to breakfast? A replicate crossover trial
    Javier Thomas Gonzalez, Lorenzo Lolli, Rachel C. Veasey, Penny Louise Sheena Rumbold, James A. Betts, Greg Atkinson, Emma Stevenson · 2024 · European Journal of Nutrition
19. Avoiding causal fraud in the evaluation of clinical benefits of treatments for Alzheimer's disease
    Kathy Y Liu, Stephen John Senn, Robert J. Howard · 2025 · Alzheimer s & Dementia
20. Identifying treatment responders using counterfactual modeling and potential outcomes
    Raphaël Porcher, Justine Jacot, Jay Steven Wunder, David Jean Biau · 2018 · Statistical Methods in Medical Research
21. Enrichment designs using placebo nonresponders
    Norbert Benda, Britta Haenisch · 2020 · Pharmaceutical Statistics
22. Using population crossover trials to improve the decision process regarding treatment individualization in N‐of‐1 trials
    FRANCISCO JAVIER DÍAZ · 2021 · Statistics in Medicine
23. Estimating individual benefits of medical or behavioral treatments in severely ill patients
    FRANCISCO JAVIER DÍAZ · 2017 · Statistical Methods in Medical Research
24. Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report
    Kiran Reddy, Neil R. Aggarwal, Narges Alipanah, Djillali Annane, David Benjamin Antcliffe, Daphne S. Babalis, John Kenneth Baillie, Abi Beane, Lieuwe D. J. Bos, Aidan J. C. Burrell et al. · 2025 · Efficacy and Mechanism Evaluation
25. Metabolic Predictors of Cardiorespiratory Fitness Responsiveness to Continuous Endurance and High-Intensity Interval Training Programs: The TIMES Study—A Randomized Controlled Trial
    Alex Castro, Antonio Gilberto Ferreira, Aparecida Maria Catai, Matheus Alejandro Bolina Amaral, Cláudia Regina Cavaglieri, Mara Patrícia Traina Chacon‐Mikahil · 2024 · Metabolites
26. Use of conditional estimates of effect in cancer epidemiology: An application to lung cancer treatment
    Jazeel Abdulmajeed, Malkan Khatib, Mohamad Wajeh Dulli, Stephanie Sioufi, Azhar Al-Khulaifi, Jennifer Stone, Luis Furuya‐Kanamori, Adedayo A. Onitilo, Suhail A.R. Doi · 2023 · Cancer Epidemiology
27. The “Small” Clinical Trial: Methods, Analysis, and Interpretation in Acute Care Cardiology
    Fernando Godinho Zampieri, Justin Adrian Ezekowitz · 2024 · Canadian Journal of Cardiology
28. Design and analysis of randomized clinical trials of embryo diagnostics: phase 3
    Jack Wilkinson, Linnea R. Goodman, Micah J. Hill, Emre U Seli, Eric J. Forman · 2025 · Fertility and Sterility
29. Epenthetic vowel production of unfamiliar medial consonant clusters by Japanese speakers
    Wakayo Mattingley, Kathleen Currie Hall, Elizabeth V. Hume · 2019 · Laboratory Phonology Journal of the Association for Laboratory Phonology
30. Model‐Twin Randomization (MoTR) for Estimating the Recurring Individual Treatment Effect
    Eric J. Daza, Igor Matias, Logan Douglas Schneider · 2025 · Statistics in Medicine
31. Chance of response to an antidepressant: what should we say to the patient?
    Tilman Steinert · 2018 · World Psychiatry
32. Measuring individual benefits of psychiatric treatment using longitudinal binary outcomes: Application to antipsychotic benefits in non-cannabis and cannabis users
    Xuan Zhang, José de León, Benedicto Crespo‐Facorro, Francisco J. Díaz · 2020 · Journal of Biopharmaceutical Statistics
33. Two-step Randomisation: Applying the Results of Small Feasibility Studies of Interventions to Large-scale Mendelian Randomisation Studies to Robustly Infer Causal Effects on Clinical Endpoints
    Meda Sandu, Rhona A. Beynon, Rebecca Claire Richmond, Diana L. Santos Ferreira, Lucy Hackshaw‐McGeagh, George Davey Smith, Chris D. Metcalfe, J. Athene Lane, Richard W. Martin · 2019 · Preprints.org
34. Does BMI moderate the LDL cholesterol response to low-carbohydrate diets?
    Javier Thomas Gonzalez, Lorenzo Lolli, Greg Atkinson · 2024 · American Journal of Clinical Nutrition
35. Prediction of patient-reported outcomes after proximal humerus fractures in elderly patients does not appear to be a credible option
    Aleksi Rafael Reito, Antti P. Launonen, Kaspar Tootsi, Aare Märtson, Juha Paloneva, Olof Wolf, Hans E. Berg, Helle Østergaard, Inger Mechlenburg, Kenneth B. Jonsson et al. · 2025 · Bone and Joint Research
36. Concerns regarding the standard deviation of individual responses for assessing treatment response heterogeneity
    Aaron R. Caldwell, David B. Allison, Andrew William Brown, Gary L. Gadbury, Thirupathi Reddy Mokalla, R. Drew Sayer, Andrew David Vigotsky · 2025 · Journal of Applied Physiology
37. Risk–benefit trade-offs and precision utilities in phase I-II clinical trials
    Pavlos Msaouel, Juhee Lee, Peter F. Thall · 2023 · Clinical Trials
38. Key Aspects of Modern, Quantitative Drug Development
    Eric W. Gibson, Frank Bretz, Michael Looby, Björn Bornkamp · 2018 · Statistics in Biosciences
39. The Precision HYpertenSIon Care (PHYSIC) study: a double-blind, randomized, repeated cross-over study
    J. Sundström, L. Lind, S. Nowrouzi, P. Lytsy, K. Marttala, I. Ekman, P. Öhagen, Ollie Östlund · 2018 · Upsala Journal of Medical Sciences
40. Treatment effect variation in brain stimulation across psychiatric disorders
    Stephanie Homan, Whitney Muscat, Andrea Joanlanne, Nikolaos Marousis, Stefan Vetter, Erich Seifritz, Thomas Dierks, Philipp Homan · 2020 · medRxiv
41. Interindividual Variability of Acute Cardiovascular Responses to Low-Load Resistance Exercise with Different Methods of Blood Flow Restriction
    William B. Hammert, Anna Kang, Yujiro Yamada, Ryo Kataoka, Robert W. Sallberg, Emily E. Metcalf, Jeremy P. Loenneke · 2025 · Medicine & Science in Sports & Exercise
42. Individual responses: transparency is welcome, but inference needs replication and modeling
    Arthur Henrique Bossi, Guilherme Matta · 2025 · Journal of Applied Physiology
43. Why most responder analyses are misleading
    Aleksandra Turkiewicz, Marius Henriksen, Jos Runhaar, Martin Englund · 2025 · Osteoarthritis and Cartilage
44. Type 2 diabetes subtypes for precision medicine: methodological challenges and alternative prediction-based approaches
    Tim Mori, Christian Herder, Pedro Cardoso, John Dennis, Oliver Kuß · 2026 · Diabetologia
45. An Alternative to Traditional Sample Size Determination for Small Patient Populations
    Holly Jackson, Thomas Jaki · 2022 · Statistics in Biopharmaceutical Research
46. Night-to-night variability of objective sleep outcomes in youth Middle Eastern football players
    Lorenzo Lolli, Daniele Bonanno, Emmanuel Lopez, Valter Di Salvo · 2024 · Sleep Medicine
47. Exploratory analysis of the variable response to an intensive lifestyle change program for metabolic syndrome
    Scott B. Maitland, Paula M. Brauer, David M. Mutch, Dawna Royall, Doug Klein, Angelo Tremblay, Caroline Rhéaume, Khursheed N. Jeejeebhoy · 2024 · BMC Family Practice
48. Understanding the variation in salivary fluoride levels: A secondary trajectory‐based analysis of trial data
    Line Staun Larsen, Vibeke Bælum, Eero Juhani Raittio · 2025 · European Journal Of Oral Sciences
49. The central role of the concept of person in psychological science
    Lars‐Gunnar Lundh · 2022 · Journal for Person-Oriented Research
50. Noncollapsibility of the odds ratio unraveled
    Jazeel Abdulmajeed, Polychronis Kostoulas, Zumin Shi, Suhail A.R. Doi · 2023 · Current Opinion in Epidemiology and Public Health
51. Individual response to antidepressants for depression in adults – a meta-analysis and simulation study
    Klaus Munkholm, Stephanie Homan, Philipp Homan · 2019
52. Statistical Design and Reporting of Randomised Controlled Trials for Raynaud’s Phenomenon
    Jack Wilkinson, James R. Seibold · 2024 · Springer eBooks
53. Are some people more susceptible to placebos? A systematic review and meta-analysis of inter-individual variability in musculoskeletal pain
    Tobias Saueressig, Patrick J. Owen, Hugo Pedder, Svenja Kaczorowski, Clint T. Miller, Lars Donath, Daniel L. Belavý · 2024 · Journal of Pain
54. A maximum statistic for the one-sided location-scale alternative in the two-stage design
    Hidetoshi Murakami, Markus Neuhäuser · 2024 · Statistical Methods & Applications
55. Evaluating treatment effect modifiers using data from randomized two-sequence, two-period crossover clinical trials: application to a diabetes study
    Ryo Emoto, Masataka Igeta, Kota Matsui, Kiyo‐aki Ishii, Toshinari Takamura, Shigeyuki Matsui · 2025 · Journal of the Royal Statistical Society Series C (Applied Statistics)
56. Individual differences in response to dust-mite-allergen specific immunotherapy in allergic rhinitis: a meta-analysis of randomized controlled trials
    Dandan Fang, Jiajia Wang, Jingyun Li, Luo Zhang, Yuan Zhang · 2025 · Expert Review of Clinical Immunology
57. Is ‘minimum’ enough? Attending to the ‘important’ in clinically important differences
    Dinne Skjærlund Christensen, David Roe, Helene Speyer · 2025 · BMJ Evidence-Based Medicine
58. Individual oxidative stress and inflammation responses to vitamin C supplementation: Aggregated sets of n-of-1 trials
    George G. Nastos, Lorenzo Lolli, Greg Atkinson, Anastasios A. Theodorou, Vassilis Paschalis, Antonios Kyparos, Michalis G. Nikolaidis, Nikos V. Margaritelis · 2026 · Free Radical Biology and Medicine
59. Does evidence support the high expectations placed in precision medicine? A bibliographic review
    Jordi Cortés, José Antonio González, María Nuncia Medina, Markus Vogler, Marta Vilaró, Matt Elmore, Stephen John Senn, Michael Joseph Campbell, Erik Cobo · 2018 · F1000Research
60. Measuring Individual Benefits of Medical Treatments Using Longitudinal Hospital Data with Non-Ignorable Missing Responses Caused by Patient Discharge: Application to the Study of Benefits of Pain Management Post Spinal Fusion
    FRANCISCO JAVIER DÍAZ, Xuan Zhang, Nikos Pantazis, José de León · 2022 · Revista Colombiana de Estadística
61. Reply
    Carlos Moctezuma‐Velázquez, Sylvia Kalainy, Juan G. Abraldeṣ · 2017 · Liver Transplantation
62. Constant effect in randomized clinical trials with quantitative outcome : a methodological review
    Jordi Cortés · 2021
63. Analyzing and interpreting patient-reported outcome measures in clinical trials: comment on Collister et al.
    Kevin P. Weinfurt · 2021 · Journal of Clinical Epidemiology
64. Automated Supervised Feature Selection for Differentiated Patterns of Care
    Catherine Wanjiru, William Ogallo, Girmaw Abebe Tadesse, Charles M. Wachira, Isaiah Onando Mulang, Aisha Walcott-Bryant · 2021 · arXiv (Cornell University)
65. Averting the next credibility crisis in Psychological Science: Within-person methods for personalized diagnostic and intervention
    Julia Moeller · 2021
66. Concerning Pharmacogenetics, Pharmacogenomics and Personalized Medicine
    Stephen John Senn · 2021
67. Often claimed, rarely tested: differences in individual drug response
    Stephanie Homan, Stefan Leucht, John Michael Kane, Philipp Homan · 2018
68. Inference in the Data Science Era –Do we Need a New Epistemological Debate in the Social Sciences?
    Julia Moeller, Daniela Schmidt · 2023
69. Are there interindividual differences in the reactive hypoglycaemia response to breakfast? A replicate crossover trial
    Javier Thomas Gonzalez, Lorenzo Lolli, Rachel C. Veasey, Penny Louise Sheena Rumbold, James A. Betts, Emma Stevenson · 2024 · Research Square
70. Are there interindividual differences in the reactive hypoglycaemia response to breakfast? A replicate crossover trial
    Javier Thomas Gonzalez, Lorenzo Lolli, Rachel C. Veasey, Penny Louise Sheena Rumbold, James A. Betts, Emma Stevenson, Greg Atkinson · 2024 · Research Square
71. New initiatives in critical care: distinguishing hype from hope
    John L. Moran, P. J. Solomon · 2016 · Critical Care and Resuscitation
72. Often claimed, rarely tested: individual drug response in antipsychotic drug trials
    Stephanie Winkelbeiner, Stefan Leucht, John Michael Kane, Philipp Homan · 2019 · European Neuropsychopharmacology
73. Quantifying the Inter-Individual Variation in Response to Exercise Interventions
    Philip Williamson · 2018
74. References
    Richard D Riley, Jayne F. Tierney, Lesley A. Stewart · 2021 · Wiley eBooks
75. Cross‐Over Trials
    Stephen John Senn · 2021
76. Pharmaco‐economics and Portfolio Management
    Stephen John Senn · 2021
77. Design and Interpretation of Clinical Trials as Seen by a Statistician
    Stephen John Senn · 2021
78. The Measurement of Treatment Effects
    Stephen John Senn · 2021
79. Safety Data, Harms, Drug Monitoring and Pharmaco‐Epidemiology
    Stephen John Senn · 2021
80. Dose‐Finding
    Stephen John Senn · 2021
81. Allocating Treatments to Patients in Clinical Trials
    Stephen John Senn · 2021
82. New Concepts in Risk Stratification
    Juan G. Abraldeṣ · 2022 · Springer eBooks
83. References
    2023 · The MIT Press eBooks
84. Outcome Prediction
    Buntheng Ly, Mihaela Pop, Hubert Cochet, Nicolás Duchateau, Declan P. O’Regan, Maxime Sermesant B · 2023 · Springer eBooks
85. Individual effect of diet on postprandial glycemic response and its relationship with gut microbiome profile in healthy subjects: protocol for a series of randomized N-of-1 trials
    Caetana Paes Zamparette, Bianca Luise Teixeira, Giuliano Netto Flores Cruz, Vilmar Benetti Filho, Luiz Felipe Valter de Oliveira · 2023 · medRxiv
86. Measuring the individualization potential of treatment individualization rules: Application to rules built with a new parametric interaction model for parallel-group clinical trials
    FRANCISCO JAVIER DÍAZ · 2024 · Statistical Methods in Medical Research
87. On Generalizability of Gauge Reproducibility and Repeatability Studies
    Ron S. Kenett · 2024 · SSRN Electronic Journal
88. Avoiding Hysteron Proteron: Use of Meta-Analysis for Examining Exercise Response Variation
    George A. Kelley, Kristi Sharpe Kelley, Brian L. Stauffer · 2025 · Journal of Clinical Exercise Physiology
89. Training and match running distances and perceived exertion at sea-level and altitude in elite North American soccer: A natural longitudinal cross-over case series
    Garrison Draper, Paul Chesterton, Tim J.U. Thompson, Matthew Wright · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
90. Using historical controls to evaluate resistance training-induced strength adaptations: Does history repeat itself?
    William B. Hammert, Yujiro Yamada, Robert W. Sallberg, Emily E. Metcalf, Ryo Kataoka, Jun Seob Song, Scott J. Dankel, Zachary W. Bell, Jeremy P. Loenneke · 2025 · Journal of Sports Sciences
91. Overcoming treatment implementation barriers for individuals with rare diseases using single-case experimental designs
    Annelieke R. Müller, Bibiche den Hollander, Agnies M. van Eeghen, Peter M. van de Ven, Martina Cornelia Cornel, Mieke M. van Haelst, Jan J. Sprengers, Hilgo Bruining, Marion M. M. G. Brands, Clara van Karnebeek · 2025 · Genetics in Medicine
92. Training and match running distances and perceived exertion at sea-level and altitude in elite male North American soccer: A natural longitudinal cross-over multi-year exploratory case series
    Garrison Draper, Paul Chesterton, Tim J.U. Thompson, Matthew Wright · 2025 · Football Studies
93. Rapid Hepatic Function Improvement with Culturally Adapted Low-Carbohydrate Paleolithic Diet in South Asian Adults with Metabolic Dysfunction: A 12-Week Prospective Study with Predictive Modeling
    V Hariharan, Chinnathambipalayam Kandasamy Vijayasamundeeswari · 2025 · Journal of Clinical Medicine of Kazakhstan
94. Surgical and N95 Masks in Chronic Hypercapnic Respiratory Failure: What Physiology Can and Cannot Tell Us
    Brian W. Locke · 2026 · Respiratory Care
95. Inter-individual variability in pain perception and sensitivity responses to low-load exercise with an absolute or relative blood flow restriction pressure
    Yujiro Yamada, Anna Kang, William B. Hammert, Robert W. Sallberg, Ryo Kataoka, Emily E. Metcalf, Jeremy P. Loenneke · 2026 · Journal of Sports Sciences
96. A novel dietary intervention with tailored behavioural support to increase legume consumption in university students: a pilot trial
    Patrick S. Elliott, Lauren D. Devine, Eileen R. Gibney, Aifric M O’Sullivan · 2026 · Food Quality and Preference
97. Treatment effect heterogeneity of exercise therapy for chronic non-specific low back pain: A meta-analysis
    Jialin Wang, Zhoupeng Lu, Peng Zhao, Bing Hu, Xiaoya Zhang, Shuyi Nie, Mingfen Fu, Xuanhui Guo, Yubo Wang, Benxiang He · 2026 · Sports Medicine and Health Science
98. Efficiency Enhancement in Testing Treatment Efficacy Across Multiple Populations Using Treatment Crossover Data
    Ryo Emoto, Kiyoaki Ishii, Toshinari Takamura, Shigeyuki Matsui · 2026 · Statistics in Medicine
99. Connecting diet and disease: Using Mendelian randomisation to bridge the gap
    Benedita Deslandes, Laura J. Corbin, Lucy J. Goudswaard, Meda Sandu, Matthew A. Lee, Rhona A. Beynon, Lucy McGeagh, George Davey Smith, Naveed A. Sattar, Michael E. J. Lean et al. · 2026 · medRxiv
100. One size fits none: A call for an idionomic revolution
     Steven C. Hayes, Joseph Ciarrochi, Baljinder Kaur Sahdra, Stefan G. Hofmann, Clarissa W. Ong, Cristóbal Hernández · 2026 · Clinical Psychology Review