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Cited by 6Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionPsychological Treatments and Disorders

The Drug Treatment of Anxiety and Panic Disorder

Rickels, Karl, Case, Warren G., Schweizer, Edward·1988·Stress Medicine
DOI 10.1002/smi.2460040408
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Abstract

Abstract The mainstay of drug treatment of non‐psychotic anxiety is the benzodiazepine group of drugs, but major side‐effects are sedation and dose‐related psychomotor, cognitive and memory impairments. However, tolerance to sedation‐related side‐effects usually develops, although not to the anxiolytic effects. Buspirone, an azaspiro‐decanedione, is the first FDA‐approved non‐benzodiazepine anxiolytic. Anxiolytic efficacy similar to the benzodiazepines has been established, although the onset of effect is more gradual. Infrequent side‐effects are dizziness, nausea, headaches, nervousness and lightheadedness; but it would not appear to cause sedation, memory effects or physical dependence. In a double‐blind prospective study to compare buspirone to clorazepate, withdrawal effects occurred with the latter but not with the former. In formulating treatment strategies for anxiety and panic disorders, consideration should be given to the duration of symptoms and likely duration of therapy, and anxiolytics should be titrated to the lowest possible dose consistent with maximal relief of anxiety and the least adverse effects.

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Authors
Rickels, K., Case, W. G., & Schweizer, E.
Affiliations
University of Pennsylvania (US)
Venue
Stress Medicine
Publisher
Wiley
Published
1988-10
Volume
4
Issue
4
Pages
231-239
ISSN
  • 0748-8386 (ISSN-L)
  • 1099-1700
DOI
10.1002/smi.2460040408
OpenAlex
W2092257372
Cited by
6
References
38
Citations by year
2022: 1 · 2021: 1
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6341 d)
Locations
Stress Medicine (publishedVersion)
Funders
U.S. Public Health Service
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
Keywords
anxiety disorders, panic disorder, benzodiazepines, buspirone, non-benzodiazepine anxiolytics, sedation, adverse drug reactions, tolerance (pharmacology and immunology), clorazepate, withdrawal effects, treatment duration

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